False-positive prenatal diagnosis of trisomy 18 by interphase FISH: Hybridization of chromosome 18 alpha-satellite probe (D18Z1) to chromosome 2

Prenatal Diagnosis

Volumn 29, Issue 13, 2009, Pages 1279-1281

  Collin, Anna ^a   Sladkevicius, Povilas ^a   Soller, Maria ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Chromosome 18 alpha satellite probe; Chromosome 2; D18Z1; False positive; FISH; General cytogenetics; Prenatal cytogenetics

Indexed keywords

ADULT; AMNIOCENTESIS; AMNION CELL; ARTICLE; CASE REPORT; CHROMOSOME 18; CHROMOSOME 2; CHROMOSOME ANALYSIS; CHROMOSOME SATELLITE; CHROMOSOME VARIANT; CYTOGENETICS; FALSE POSITIVE RESULT; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; PRENATAL DIAGNOSIS; PRENATAL SCREENING; PRIORITY JOURNAL; TRISOMY 18;

ADULT; CHROMOSOMES, HUMAN, PAIR 18; CHROMOSOMES, HUMAN, PAIR 2; DNA PROBES; FALSE POSITIVE REACTIONS; FEMALE; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; INFANT, NEWBORN; MALE; PREGNANCY; PRENATAL DIAGNOSIS; TRISOMY;

EID: 73449098628     PISSN: 01973851     EISSN: 10970223     Source Type: Journal    
DOI: 10.1002/pd.2401     Document Type: Article

References (6)

1. Graf MD, Gill P, Krew M, Schwartz S. 2002. Prenatal detection of structural abnormalities of chromosome 18: associations with interphase fluorescence in situ hybridization (FISH) and maternal serum screening. Prenat Diagn 22: 645-648.
2. Gravholt CH, Bugge M, Strømkjær H, et al. 1997. A patient with Edwards syndrome caused by a rare pseudodicentric chromosome 18 of paternal origin. Clin Genet 52: 56-60.
3. Skinner JL, Govberh IJ, Ralph T, DePalma RT, Cotter PD. 2001. Heteromorphism of chromosome 18 can obscure detection of fetal aneuploidy by interphase FISH. Prenat Diagn 21: 702-704.
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5. Wei S, Mok Siu V, Decker A, et al. 2007. False-positive prenatal diagnosis of trisomy 18 by interphase FISH: hybridization of chromosome 18 alpha-satellite DNA probe (D18Z1) to the heterochromatic region of chromosome 9. Prenat Diagn 27: 1064-1066.
6. Weremowicz S, Sandstrom DJ, Morton CC, Niedzwiecki CA, Sandstrom MM, Bieber FR. 2001. Fluorescence in situ hybridization (FISH) for rapid detection of aneuploidy: experience in 911 prenatal cases. Prenat Diagn 21: 262-269.