Effect of trimetazidine on quality of life in elderly patients with ischemic dilated cardiomyopathy

Advances in Therapy

Volumn 26, Issue 4, 2009, Pages 455-461

  Marazzi, Giuseppe ^a   Gebara, Otavio ^b   Vitale, Cristiana ^a   Caminiti, Giuseppe ^a   Wajngarten, Mauricio ^b   Volterrani, Maurizio ^a   Ramires, José A F ^b   Rosano, Giuseppe ^a   Fini, Massimo ^a  

^a IRCCS SAN RAFFAELE PISANA   (Italy)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Angina; Ischemia; Quality of life; Trimetazidine

Indexed keywords

ACETYLSALICYLIC ACID; ANGIOTENSIN RECEPTOR ANTAGONIST; ANTICOAGULANT AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL STIMULATING AGENT; CLOPIDOGREL; DIGITALIS; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; GLYCERYL TRINITRATE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INSULIN; METFORMIN; NITRIC ACID DERIVATIVE; PLACEBO; TICLOPIDINE; TRIMETAZIDINE;

ADULT; AGED; ANGINA PECTORIS; ANGIOGRAPHY; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG DOSE REDUCTION; FEMALE; HEART INFARCTION; HEART LEFT VENTRICLE FUNCTION; HUMAN; ISCHEMIC HEART DISEASE; MALE; MULTICENTER STUDY; QUALITY OF LIFE; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; STABLE ANGINA PECTORIS; TREATMENT DURATION; VISUAL ANALOG SCALE;

AGED; CARDIOMYOPATHY, DILATED; CORONARY DISEASE; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; ECHOCARDIOGRAPHY; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MYOCARDIAL ISCHEMIA; QUALITY OF LIFE; QUESTIONNAIRES; SEVERITY OF ILLNESS INDEX; STATISTICS, NONPARAMETRIC; TREATMENT OUTCOME; TRIMETAZIDINE; VASODILATOR AGENTS; VENTRICULAR DYSFUNCTION, LEFT;

EID: 73449098192     PISSN: 0741238X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12325-009-0024-7     Document Type: Article

References (22)

1. S. Yusuf S. Reddy S. Ounpuu S. Anand 2001 Global burden of cardiovascular diseases: part I: general considerations, the epidemiologic transition, risk factors, and impact of urbanization Circulation 104 46 53
2. D. Harpaz Y. Rozenman S. Behar 2007 Coronary angiography in the elderly with acute myocardial infarction Int J Cardiol 116 249 256 16839633 10.1016/j.ijcard.2006.03.054 (Pubitemid 46251571)
3. J. Czernin P. Muller S. Chan 1993 Influence of age and hemodynamics on myocardial blood flow and flow reserve Circulation 88 62 69 8319357 1:STN:280:DyaK3szgs1ygtg%3D%3D
4. P.F. Cohn 1986 Silent myocardial ischemia: dimensions of the problem in patients with and without angina Am J Med 80 suppl.4C 3 8 3706355 10.1016/0002-9343(86)90446-8 1:STN:280:DyaL283ht1akug%3D%3D
5. G.M. Rosano M. Fini G. Caminiti G. Barbaro 2008 Cardiac metabolism in myocardial ischemia Curr Pharm Des 14 2551 2562 18991672 10.2174/ 138161208786071317 1:CAS:528:DC%2BD1MXhvFSkug%3D%3D
6. W.C. Stanley 2001 Cardiac energetics during ischaemia and the rationale for metabolic interventions Coron Artery Dis 12 suppl.1 S3 S7 11286306
7. P.F. Kantor A. Lucien R. Kozak 2000 The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial longchain 3-ketoacyl coenzyme A thiolase Circ Res 86 580 588 10720420 1:CAS:528:DC%2BD3cXitFWgsrk%3D
8. N. Lavanchy J. Martin A. Rossi 1987 Anti-ischemia effects of trimetazidine: 31P-NMR spectroscopy in the isolated rat heart Arch Int Pharmacodyn Ther 286 97 110 3592863 1:CAS:528:DyaL2sXktVSmt7s%3D
9. G.D. Lopaschuk 2001 Optimizing cardiac energy metabolism: how can fatty acid and carbohydrate metabolism be manipulated? Coron Artery Dis 12 suppl.1 S8 S11 11286307
10. C. Vitale M. Wajngaten B. Sposato 2004 Trimetazidine improves left ventricular function and quality of life in elderly patients with coronary artery disease Eur Heart J 25 1814 1821 15474696 10.1016/j.ehj.2004.06.034 1:CAS:528:DC%2BD2cXotlSmu7s%3D (Pubitemid 39330232)
11. R. Belardinelli A. Purcaro 2001 Effects of trimetazidine on the contractile response of chronically dysfunctional myocardium to low-dose dobutamine in ischaemic cardiomyopathy Eur Heart J 22 2164 2170 11913478 10.1053/euhj.2001.2653 1:CAS:528:DC%2BD38XisV2ltg%3D%3D (Pubitemid 33139462)
12. G. Fragasso A. Palloshi P. Puccetti 2006 A randomized clinical trial of trimetazidine, a partial free fatty acid oxidation inhibitor, in patients with heart failure J Am Coll Cardiol 48 992 998 16949492 10.1016/j.jacc.2006.03.060 1:CAS:528:DC%2BD28XpsVWmtbY%3D (Pubitemid 44292461)
13. L. Campeau 1976 Grading of angina pectoris [Letter] Circulation 54 522 523 947585 1:STN:280:DyaE283jsVejsA%3D%3D
14. S. Höfer L. Lim G. Guyatt N. Oldridge 2004 The MacNew Heart Disease health-related quality of life instrument: a summary Health Qual Life Outcomes 2 3 14713315 10.1186/1477-7525-2-3 (Pubitemid 39115370)
15. T.R. McConnell C.A. Laubach M. Memon J.K. Gardner T.A. Klinger R.J. Palm 2000 Quality of life and self efficacy in cardiac rehabilitation patients over 70 years of age following acute myocardial infarction and bypass revascularization surgery Am J Geriatr Cardiol 9 210 218 11416568 10.1111/j.1076-7460.2000.80040.x
16. N. Oldridge M. Gottlieb G. Guyatt N. Jones D. Streiner D. Feeny 1998 Predictors of health-related quality of life with cardiac rehabilitation after acute myocardial infarction J Cardiopulm Rehabil 18 95 103 9559446 10.1097/00008483-199803000-00002 1:STN:280:DyaK1c3itVajsg%3D%3D (Pubitemid 28175820)
17. S. Hofer W. Benzer G. Schussler N. von Steinbuchel N.B. Oldridge 2003 Health-related quality of life in patients with coronary artery disease treated for angina: validity and reliability of German translations of two specific questionnaires Qual Life Res 12 199 212 12639066 10.1023/A:1022272620947 1:STN:280:DC%2BD3s7isVyisA%3D%3D (Pubitemid 36255784)
18. T.K. Hillers G.H. Guyatt N. Oldridge 1994 Quality of life after myocardial infarction J Clin Epidemiol. 47 1287 1296 7722565 10.1016/0895-4356(94)90134-1 1:STN:280:DyaK2M3jvFamsA%3D%3D (Pubitemid 24361537)
19. G.M. Rosano C. Vitale B. Sposato G. Mercuro M. Fini 2003 Trimetazidine improves left ventricular function in diabetic patients with coronary artery disease: a double-blind placebo-controlled study Cardiovasc Diabetol 2 16 14641923 10.1186/1475-2840-2-16 (Pubitemid 38751097)
20. L.D. Monti E. Setola G. Fragasso 2006 Metabolic and endothelial effects of trimetazidine on forearm skeletal muscle in patients with type 2 diabetes and ischemic cardiomyopathy Am J Physiol Endocrinol Metab 290 E54 E59 16174656 10.1152/ajpendo.00083.2005 1:CAS:528:DC%2BD28XhsVSis70%3D
21. R. Andrews J.T. Walsh A. Evans S. Curtis A.J. Cowley 1997 Abnormalities of skeletal muscle metabolism in patients with chronic heart failure: evidence that they are present at rest Heart 77 159 163 9068400 1:STN:280: DyaK2s3itFemtg%3D%3D
22. M. Emre I. Karayaylali M. San A. Demirkazik S. Kavak 2004 The acute effect of trimetazidine on the high frequency fatigue in the isolated rat diaphragm muscle Arch Pharm Res 27 646 652 15283468 10.1007/BF02980165 1:CAS:528:DC%2BD2cXlvFWms78%3D