Biomechanical and histological outcome of combined raloxifene-estrogen therapy on skeletal and reproductive tissues

European Journal of Pharmacology

Volumn 627, Issue 1-3, 2010, Pages 354-361

  Tasci, Arzu ^a   Bilgili, Hasan ^b   Altunay, Hikmet ^c   Gecit, Mehmet Rusen ^d   Keskin, Dilek ^d  

^a UNIVERSITY OF BERN   (Switzerland)

^b ANKARA UNIVERSITY   (Turkey)

^c MEHMET AKIF ERSOY UNIVERSITY   (Turkey)

^d MIDDLE EAST TECHNICAL UNIVERSITY   (Turkey)

Author keywords

Antagonist; Estrogen Receptor; Osteoporosis; Raloxifene; Uterus

Indexed keywords

ESTRADIOL; RALOXIFENE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; BONE DENSITY; BONE STRENGTH; BONE TISSUE; CONTROLLED STUDY; DRUG POTENTIATION; ESTROGEN THERAPY; EXPERIMENTAL MODEL; FEMALE; IMMUNITY; NONHUMAN; OSTEOPOROSIS; OVARIECTOMY; PRIORITY JOURNAL; RAT; TISSUE SECTION; TREATMENT OUTCOME; UTERUS DISEASE; VASCULARIZATION; WISTAR RAT;

ANIMALS; BODY WEIGHT; BONE AND BONES; BONE DENSITY; DRUG THERAPY, COMBINATION; ESTROGENS; FEMALE; FEMUR; FRACTURES, BONE; ORGAN SPECIFICITY; OSTEOPETROSIS; RALOXIFENE; RATS; RATS, WISTAR; RISK; TIBIA; UTERUS;

EID: 73449097107     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2009.11.002     Document Type: Article

References (38)

1. An Y., and Draughn R.A. Mechanical properties and testing methods of bone. In: An Y.H., and Friedman R.J. (Eds). Animal Models in Orthopaedic Research (1998), CRC Press 145
2. Bourrin S., Ammann P., Bonjour J.P., and Rizzoli R. Recovery of proximal tibia bone mineral density and strength, but not cancellous bone architecture, after long term bisphosphonate or selective estrogen receptor modulator therapy in aged rats. Bone 30 (2000) 195-200
3. Brouwers J.E.M., Rietbergen B.v., and Huiskes R. Effects of PTH treatment on tibial bone of ovariectomized rats assessed by in vivo micro-CT. Osteoporos. Int. (2009) 20 (11), 1823-1835. PMID: 19262974vv
4. Bryant H.U., and Dere W.H. Selective estrogen receptor modulators: an alternative to hormone replacement therapy. Proc. Soc. Exp. Biol. Med. 217 (1998) 45-52
5. Cosman F., and Lindsay R. Selective estrogen receptor modulators: clinical spectrum. Endocr. Rev. 20 (1999) 418-434
6. Cox D.A., and Helvering L.M. Extracellular matrix integrity: a possible mechanism for differential clinical effects among selective estrogen receptor modulators and estrogens?. Mol. Cell. Endocrinol. 247 (2006) 53-59
7. Crabtree J.S., Peano B.J., and Zhang X. Activity of three selective estrogen receptor modulators on hormone-dependent responses in the mouse uterus and mammary gland. Mol. Cell. Endocrinol. 287 (2008) 40-46
8. Cummings S.R., Black D.M., and Nevitt M.C. Bone density at various sites of prediction of hip fractures. Lancet 341 (1993) 72-75
9. EASL, 2009. European Association for the Study of the Liver Clinical Practice Guidelines: Management of cholestatic liver diseases. Journal of Hepatology 27 (2). doi:10.1016/j.ejphar.2009.11.002.
10. Ettinger B., Black D., and Cummings S. Raloxifene reduces the risk of incident vertebral fractures: 24-month interim analysis. Osteoporos. Int. S3 (1998) 11
11. Goldrace M.J., Roberts S.E., and Yeates D. Mortality after admission to hospital with fractured neck of femur: database study. BMJ 325 (2002) 868-869
12. Greenspan S.L., Maitland L.A., and Myers E.R. Femoral bone loss progresses with age: a longitudinal study in women over age 65. J. Bone Miner. Res. 9 (1994) 1959-1965
13. Hodsman A.B., Watson P.H., and Drost D. Assessment of maintenance therapy with reduced doses of PTH (1-34) in combination with a raloxifene analogue (LY117018) following anabolic therapy in the ovariectomized rat. Bone 24 (1999) 451-455
14. Jee W.S.S., and Yao W. Overview: animal models of osteopenia and osteoporosis. J. Musculoskelet. Neuron. Interact. 1 (2001) 193-207
15. Kobayashi M., Hara K., and Akiyama Y. Effects of vitamin K2 and alendronate on bone mineral density and bone strength in rats fed a low-magnesium diet. Bone 35 (2004) 1136-1143
16. Lee W.L., Chao H.T., Cheng M.H., and Wang P.H. Rationale for using raloxifene to prevent both osteoporosis and breast cancer in postmenopausal women. Maturitas 60 (2008) 92-107
17. Lenthe G.H.V., Voide R., Boyd S.K., and Müller R. Tissue modulus calculated from beam theory is biased by bone size and geometry: implications for the use of three point bending tests to determine bone tissue modulus. Bone 43 (2008) 717-723
18. Ma Y.L., Bryant H.U., and Sato M. New bone formation with teriparatide is not retarded by long-term pretreatment with alendronate, estrogen or raloxifene in ovariectomized rats. Endocrinology 144 (2003) 2008-2015
19. Martel C., Picard S., and Richard V. Prevention of bone loss by EM-800 and raloxifene in the ovariectomized rat. J. Steroid Biochem. Mol. Biol. 74 (2000) 45-56
20. Matter H.P., Garrel T.V., Bilderbeek U., and Mittelmeier W. Biomechanical examinations of cancellous bone concerning the influence of duration and temperature of cryopreservation. J. Biomed. Mater. Res. 55 (2001) 40-44
21. 2 on three dimensional trabecular microarchitecture in ovariectomized rats. J. Bone Miner. Res. 15 (2000) 1810-1817
22. Moyad M.A. Osteoporosis: a rapid review of risk factors and screening methods. Urol. Oncol. 21 (2003) 375-379
23. Omi N., and Ezawa I. The effect of ovariectomy on bone metabolism in rats. Bone 7 (1995) 163S-168S
24. Punyadeera C., Kamps R., and Groothuis P. Effects of selective estrogen receptor modulators on proliferation in tissue cultures of pre- and postmenopausal human endometrium. J. Steroid Biochem. Mol. Biol. 112 (2008) 102-109
25. Reid I.R. Anti-resorptive therapies for osteoporosis, seminars in cell and developmental biology. Semin. Cell Dev. Biol. 19 (2008) 473-478
26. Sakhaee K., Maalouf N.M., Abrams S.A., and Pak C.Y.C. Effects of potassium alkali and calcium supplementation on bone turnover in postmenopausal women. J. Clin. Endocrinol. Metab. 90 (2005) 3528-3533
27. Sato M., Kim J., Short L.L., Slemenda C.W., and Bryant H.U. Longitudinal and cross-sectional analysis of raloxifene effects on tibiae from ovariectomized aged rats. J. Pharmacol. Exp. Ther. 272 (1995) 1252-1259
28. Smolka K., Kraehenbuehl M., Eggensperger N., Hallermann W., Thoren H., Iizuka T., and Smolka W. Fibula free flap reconstruction of the mandible in cancer patients: evaluation of a combined surgical and prosthodontic treatment concept. Oral Oncol. 44 (2008) 571-581
29. Taranta A., Brama M., and Teti A. The selective estrogen receptor modulator raloxifene regulates osteoclast and osteoblast activity in vitro. Bone 30 (2002) 368-376
30. Termine J.D., and Wong M. Post-menopausal women and osteoporosis: available choices for maintenance of skeletal health. Maturitas 30 (1998) 241-245
31. Turner C.H., and Burr D.B. Basic biomechanical measurements of bone: a tutorial. Bone 14 (1993) 595-606
32. Turner C.H., and Burr D.B. Experimental techniques for bone mechanics. Boca Raton, Florida. In: Cowin S.C. (Ed). Bone Mechanics Handbook. 2nd ed (2001), CRC Press, Boca Raton, Florida 1-8 Chapter 7
33. Turner C.H., Sato M., and Bryant H.U. Raloxifene preserves bone strength and bone mass in ovariectomized rats. Endocrinology 135 (1994) 2001-2005
34. Turner R.T., Maran A., Lotinun S., Hefferan T., Evans G.L., Zhang M., and Sibonga J.D. Animal models for osteoporosis. Rev. Endocr. Metab. Dis. 2 (2001) 117-127
35. WHI. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial. JAMA 288 (2002) 321-333
36. Wu X., Glinn M.A., and Ostrowski N.L. Raloxifene and estradiol benzoate both fully restore hippocampal choline acetyltransferase activity in ovariectomized rats. Brain Res. 847 (1999) 98-104
37. Yoshitake K., and Yokota K. Effects of 16 weeks of treatment with tibolone on bone mass and bone mechanical and histomorphometric indices in mature ovariectomized rats with established osteopenia on a low-calcium diet. Bone 25 (1999) 311-319
38. Zheng H., Kangas L., and Härkönen P. Comparative study of the short-term effects of a novel selective estrogen receptor modulator, ospemifene, and raloxifene and tamoxifen on rat uterus. J. Steroid Biochem. Mol. Biol. 88 (2004) 143-156