Effect of MarA-like proteins on antibiotic resistance and virulence in Yersinia pestis

Infection and Immunity

Volumn 78, Issue 1, 2010, Pages 364-371

  Lister, Ida M ^a   Mecsas, Joan ^a   Levy, Stuart B ^a  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; MARA47 PROTEIN; MARA48 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBIOTIC RESISTANCE; ARTICLE; ATTENUATION; BACTERIAL CHROMOSOME; BACTERIAL VIRULENCE; CONTROLLED STUDY; DRUG SENSITIVITY; FEMALE; GENE DELETION; GENE OVEREXPRESSION; MOUSE; MUTANT; NONHUMAN; PLAGUE; PNEUMONIA; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SEQUENCE HOMOLOGY; WILD TYPE; YERSINIA PESTIS;

AMINO ACID SEQUENCE; ANIMALS; BACTERIAL PROTEINS; DRUG RESISTANCE, BACTERIAL; GENE DELETION; GENE EXPRESSION REGULATION, BACTERIAL; MICE; MOLECULAR SEQUENCE DATA; PLAGUE; VIRULENCE; YERSINIA PESTIS;

EID: 73449093199     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.00904-09     Document Type: Article

References (42)

1. Alekshun, M. N., and S. B. Levy. 1997. Regulation of chromosomally mediated multiple antibiotic resistance: the mar regulon. Antimicrob. Agents Chemother. 41:2067-2075.
2. Barbosa, T. M., and S. B. Levy. 2000. Differential expression of over 60 chromosomal genes in Escherichia coli by constitutive expression of MarA. J. Bacteriol. 182:3467-3474.
3. Bennik, M. H., P. J. Pomposiello, D. F. Thorne, and B. Demple. 2000. Defining a rob regulon in Escherichia coli by using transposon mutagenesis. J. Bacteriol. 182:3794-3801.
4. Casaz, P., L. Garrity-Ryan, D. McKenney, C. Jackson, S. Levy, S. K. Tanaka, and M. Alekshun. 2006. MarA, SoxS, and Rob function as virulence factors in an Escherichia coli murine model of ascending pyelonephritis. Microbiology 152:3643-3650.
5. Cathelyn, J. S., S. D. Crosby, W. W. Lathem, W. E. Goldman, and V. L. Miller. 2006. RovA, a global regulator of Yersinia pestis, specifically required for bubonic plague. Proc. Natl. Acad. Sci. U. S. A. 103:13514-13519.
6. Cohen, S. P., H. Hachler, and S. B. Levy. 1993. Genetic and functional analysis of the multiple antibiotic resistance (mar) locus in Escherichia coli. J. Bacteriol. 175:1484-1492.
7. Domain, F., X. R. Bina, and S. B. Levy. 2007. Transketolase A, an enzyme in central metabolism, derepresses the marRAB multiple antibiotic resistance operon of Escherichia coli by interaction with MarR. Mol. Microbiol. 66: 383-394.
8. Finegold, M. J., J. J. Petery, R. F. Berendt, and H. R. Adams. 1968. Studies on the pathogenesis of plague. Blood coagulation and tissue responses of Macaca mulatta following exposure to aerosols of Pasteurella pestis. Am. J. Pathol. 53:99-114.
9. Fisher, M. L., C. Castillo, and J. Mecsas. 2007. Intranasal inoculation of mice with Yersinia pseudotuberculosis causes a lethal lung infection that is dependent on Yersinia outer proteins and PhoP. Infect. Immun. 75:429-442.
10. Galimand, M., E. Carniel, and P. Courvalin. 2006. Resistance of Yersinia pestis to antimicrobial agents. Antimicrob. Agents Chemother. 50:3233-3236.
11. Galimand, M., A. Guiyoule, G. Gerbaud, B. Rasoamanana, S. Chanteau, E. Carniel, and P. Courvalin. 1997. Multidrug resistance in Yersinia pestis mediated by a transferable plasmid. N. Engl. J. Med. 337:677-680.
12. Gallegos, M. T., R. Schleif, A. Bairoch, K. Hofmann, and J. L. Ramos. 1997. Arac/XylS family of transcriptional regulators. Microbiol. Mol. Biol. Rev. 61:393-410.
13. George, A. M., and S. B. Levy. 1983. Gene in the major cotransduction gap of the Escherichia coli K-12 linkage map required for the expression of chromosomal resistance to tetracycline and other antibiotics. J. Bacteriol. 155:541-548.
14. Griffith, K. L., M. M. Fitzpatrick, E. F. Keen, 3rd, and R. E. Wolf, Jr. 2009. Two functions of the C-terminal domain of Escherichia coli Rob: mediating "sequestration-dispersal" as a novel off-on switch for regulating Rob's activity as a transcription activator and preventing degradation of Rob by Lon protease. J. Mol. Biol. 388:415-430.
15. Hartog, E., L. Ben-Shalom, D. Shachar, K. R. Matthews, and S. Yaron. 2008. Regulation of marA, soxS, rob, acrAB and micF in Salmonella enterica serovar Typhimurium. Microbiol. Immunol. 52:565-574.
16. Heckman, K. L., and L. R. Pease. 2007. Gene splicing and mutagenesis by PCR-driven overlap extension. Nat. Protoc. 2:924-932.
17. Keeney, D., A. Ruzin, F. McAleese, E. Murphy, and P. A. Bradford. 2008. MarA-mediated overexpression of the AcrAB efflux pump results in decreased susceptibility to tigecycline in Escherichia coli. J. Antimicrob. Chemother. 61:46-53.
18. Lathem, W. W., S. D. Crosby, V. L. Miller, and W. E. Goldman. 2005. Progression of primary pneumonic plague: a mouse model of infection, pathology, and bacterial transcriptional activity. Proc. Natl. Acad. Sci. U. S. A. 102:17786-17791.
19. Liu, H., H. Wang, J. Qiu, X. Wang, Z. Guo, Y. Qiu, D. Zhou, Y. Han, Z. Du, C. Li, Y. Song, and R. Yang. 2009. Transcriptional profiling of a mice plague model: insights into interaction between Yersinia pestis and its host. J. Basic Microbiol. 49:92-99.
20. Logsdon, L. K., and J. Mecsas. 2003. Requirement of the Yersinia pseudotuberculosis effectors YopH and YopE in colonization and persistence in intestinal and lymph tissues. Infect. Immun. 71:4595-4607.
21. Maneewannakul, K., and S. B. Levy. 1996. Identification of mar mutants among quinolone-resistant clinical isolates of Escherichia coli. Antimicrob. Agents Chemother. 40:1695-1698.
22. Matthews, M., and C. R. Roy. 2000. Identification and subcellular localization of the Legionella pneumophila IcmX protein: a factor essential for establishment of a replicative organelle in eukaryotic host cells. Infect. Immun. 68:3971-3982.
23. Morris, S. R. 2007. Development of a recombinant vaccine against aerosolized plague. Vaccine 25:3115-3117.
24. Oethinger, M., I. Podglajen, W. V. Kern, and S. B. Levy. 1998. Overexpression of the marA or soxS regulatory gene in clinical topoisomerase mutants of Escherichia coli. Antimicrob. Agents Chemother. 42:2089-2094.
25. Perry, R. D., and J. D. Fetherston. 1997. Yersinia pestis-etiologic agent of plague. Clin. Microbiol. Rev. 10:35-66.
26. Pomposiello, P. J., M. H. Bennik, and B. Demple. 2001. Genome-wide transcriptional profiling of the Escherichia coli responses to superoxide stress and sodium salicylate. J. Bacteriol. 183:3890-3902.
27. Pomposiello, P. J., and B. Demple. 2000. Identification of SoxS-regulated genes in Salmonella enterica serovar Typhimurium. J. Bacteriol. 182:23-29.
28. Prentice, M. B., and L. Rahalison. 2007. Plague. Lancet 369:1196-1207.
29. Prieto, A. I., S. B. Hernandez, I. Cota, M. G. Pucciarelli, Y. Orlov, F. Ramos-Morales, F. Garcia-del Portillo, and J. Casadesus. 2009. Roles of the outer membrane protein AsmA of Salmonella enterica in the control of marRAB expression and invasion of epithelial cells. J. Bacteriol. 191:3615-3622.
30. Reece, K. S., and G. J. Phillips. 1995. New plasmids carrying antibioticresistance cassettes. Gene 165:141-142.
31. Rhee, S., R. G. Martin, J. L. Rosner, and D. R. Davies. 1998. A novel DNA-binding motif in MarA: the first structure for an AraC family transcriptional activator. Proc. Natl. Acad. Sci. U. S. A. 95:10413- 10418.
32. Rosenberg, E. Y., D. Bertenthal, M. L. Nilles, K. P. Bertrand, and H. Nikaido. 2003. Bile salts and fatty acids induce the expression of Escherichia coli AcrAB multidrug efflux pump through their interaction with Rob regulatory protein. Mol. Microbiol. 48:1609-1619.
33. Ruiz, C., L. M. McMurry, and S. B. Levy. 2008. Role of the multidrug resistance regulator MarA in global regulation of the hdeAB acid resistance operon in Escherichia coli. J. Bacteriol. 190:1290-1297.
34. Schneiders, T., T. M. Barbosa, L. M. McMurry, and S. B. Levy. 2004. The Escherichia coli transcriptional regulator MarA directly represses transcription of purA and hdeA. J. Biol. Chem. 279:9037-9042.
35. Schneiders, T., and S. B. Levy. 2006. MarA-mediated transcriptional repression of the rob promoter. J. Biol. Chem. 281:10049-10055.
36. Simon, R., U. Priefer, and A. Puhler. 1983. A broad host range mobilization system for in vivo genetic engineering: transposon mutagenesis in Gram negative bacteria. Biotechnology (NY) 1:784-791.
37. Sodeinde, O. A., Y. V. Subrahmanyam, K. Stark, T. Quan, Y. Bao, and J. D. Goguen. 1992. A surface protease and the invasive character of plague. Science 258:1004-1007.
38. Stenseth, N. C., B. B. Atshabar, M. Begon, S. R. Belmain, E. Bertherat, E. Carniel, K. L. Gage, H. Leirs, and L. Rahalison. 2008. Plague: past, present, and future. PLoS Med. 5:e3.
39. Thompson, J. D., D. G. Higgins, and T. J. Gibson. 1994. CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res. 22:4673-4680.
40. Titball, R. W., and E. D. Williamson. 2004. Yersinia pestis (plague) vaccines. Expert Opin. Biol. Ther. 4:965-973.
41. Udani, R. A., and S. B. Levy. 2006. MarA-like regulator of multidrug resistance in Yersinia pestis. Antimicrob. Agents Chemother. 50:2971-2975.
42. - or Pstr phenotypes of Yersiniae. Infect. Immun. 43:895-900.