Intra-periaqueductal grey microinjections of an imidazo[1,2-b]pyridazine derivative, DM2, affects rostral ventromedial medulla cell activity and shows antinociceptive effect

Neuropharmacology

Volumn 58, Issue 3, 2010, Pages 660-667

  Palazzo, Enza ^a   Rimoli, Maria Grazia ^b   De Chiaro, Maria ^a   Guida, Francesca ^a   Melisi, Daniela ^b   Curcio, Annalisa ^b   de Novellis, Vito ^a   Marabese, Ida ^a   Rossi, Francesco ^a   Abignente, Enrico ^b   Maione, Sabatino ^a  

^a SECOND UNIVERSITY OF NAPLES   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Ethosuximide; Imidazo 1,2 b pyridazine; Inflammatory pain; PAG; RVM

Indexed keywords

6 METHOXY 2 PHENYLIMIDAZO[1,2 B]PYRIDAZINE 3 CARBOXYLIC ACID; ETHOSUXIMIDE; FORMALDEHYDE; PYRIDAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; HEART RATE; INFLAMMATION; MALE; MEDULLA OBLONGATA; MICROINJECTION; NONHUMAN; PAIN; PERIAQUEDUCTAL GRAY MATTER; PRIORITY JOURNAL; RAT; ROSTRAL VENTROMEDIAL MEDULLA; TAIL FLICK TEST;

ACTION POTENTIALS; ANALGESICS; ANIMALS; ANTICONVULSANTS; BLOOD PRESSURE; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHOSUXIMIDE; FORMALDEHYDE; HEART RATE; MALE; MEDULLA OBLONGATA; MICROINJECTIONS; NEURONS; PAIN; PAIN MEASUREMENT; PERIAQUEDUCTAL GRAY; PYRIDINES; RATS; RATS, WISTAR; REACTION TIME; TIME FACTORS;

EID: 73449091793     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2009.11.006     Document Type: Article

References (62)

1. Abignente E., Arena F., Luraschi E., De Caprariis P., Marmo E., Vitagliano S., and Donnoli D. Research on heterocyclic compounds. XXVI. Antiinflammatory and related activities of some 2-phenylimidazo[1,2-b]pyridazines. Research Communications in Chemical Pathology and Pharmacology 67 (1990) 43-54
2. Abignente E., Arena F., Luraschi E., Saturnino C., Marmo E., Berrino L., and Donnoli D. Research on heterocyclic compounds. XXVII. Synthesis and anti-inflammatory activity of 2-phenylimidazo[1,2-b]pyridazine-3-carboxylic acids. Farmaco 45 (1990) 1075-1087
3. Abignente E., Arena F., De Caprariis P., Luraschi E., Sacchi A., Lampa E., Berrino L., and Donnoli D. Research on heterocyclic compounds. XXVIII. Imidazo[1,2-c]pyrimidines. Farmaco 46 (1991) 1099-1110
4. Aimone L.D., and Gebhart G.F. Stimulation-produced spinal inhibition from the midbrain in the rat is mediated by an excitatory amino acid neurotransmitter in the medial medulla. Journal of Neuroscience 6 (1986) 1803-1813
5. Basbaum A.I., and Fields H.L. Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry. Annual Review in Neuroscience 7 (1984) 309-338
6. Bee L.A., and Dickenson A.H. Rostral ventromedial medulla control of spinal sensory processing in normal and pathophysiological states. Neuroscience 147 (2007) 786-793
7. Berrino L., Oliva P., Rossi F., Palazzo E., Nobili B., and Maione S. Interaction between metabotropic and NMDA glutamate receptors in the periaqueductal grey pain modulatory system. Naunyn Schmiedebergs Archives of Pharmacology 364 (2001) 437-443
8. Bishnoi M., Chopra K., and Kulkarni S.K. Protective effect of L-type calcium channel blockers against haloperidol-induced orofacial dyskinesia: a behavioural, biochemical and neurochemical study. Neurochemistry Research 33 (2008) 1869-1880
9. Bourinet E., Alloui A., Monteil A., Barrère C., Couette B., Poirot O., Pages A., McRory J., Snutch T.P., Eschalier A., and Nargeot J. Silencing of the Cav3.2 T-type calcium channel gene in sensory neurons demonstrates its major role in nociception. The EMBO Journal 24 (2005) 315-324
10. Cameron A.A., Khan I.A., Westlund K.N., and Willis W.D. The efferent projections of the periaqueductal gray in the rat: a Phaseolus vulgaris-leucoagglutinin study. II. Descending projections. Journal of Comparative Neurolology 351 (1995) 585-601
11. Choi S., Na H.S., Kim J., Lee J., Lee S., Kim D., Park J., Chen C.C., Campbell K.P., and Shin H.S. Attenuated pain responses in mice lacking Ca(V)3.2 T-type channels. Genes Brain Behaviour 6 (2007) 425-431
12. Coderre T.J., Vaccarino A.L., and Melzack R. Central nervous system plasticity in the tonic pain response to subcutaneous formalin injection. Brain Research 535 (1990) 155-158
13. de Novellis V., Palazzo E., Rossi F., De Petrocellis L., Petrosino S., Guida F., Luongo L., Migliozzi A., Cristino L., Marabese I., Starowicz K., Di Marzo V., and Maione S. The analgesic effect of N-arachidonoyl-serotonin, a FAAH inhibitor and TRPV1 receptor antagonist, associated with changes in rostral ventromedial medulla and locus coeruleus cell activity in rats. Neuropharmacology 55 (2008) 1105-1113
14. Dickenson A.H., and Sullivan A.F. Peripheral origins and central modulation of subcutaneous formalin-induced activity of rat dorsal horn neurones. Neuroscience Letters 83 (1987) 207-211
15. Dray A., Urban L., and Dickenson A. Pharmacology of chronic pain. Trends in Pharmacological Science 15 (1994) 190-197
16. Dubuisson D., and Dennis S.G. The formalin test: a quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats. Pain 4 (1977) 161-174
17. Fields H.L. Pain modulation: expectation, opioid analgesia and virtual pain. Progress in Brain Research 122 (2000) 245-253
18. Fields H.L., and Basbaum A.I. Central Nervous System Mechanisms of Pain Modulation (1994), Churchill Livingstone, Edinburg
19. Fields H.L., Vanegas H., Hentall I.D., and Zorman G. Evidence that disinhibition of brain stem neurones contributes to morphine analgesia. Nature 306 (1983) 684-686
20. Fields H.L., Heinricher M.M., and Mason P. Neurotransmitters in nociceptive modulatory circuits. Annual Review Neuroscience 14 (1991) 219-245
21. Fields H.L., Malick A., and Burstein R. Dorsal horn projection targets of ON and OFF cells in the rostral ventromedial medulla. Journal of Neurophysiology 74 (1995) 1742-1759
22. Fields H.L., and Heinricher M.M. Anatomy and physiology of a nociceptive modulatory system. Philosophical Transactions of the Royal Society B: Biological Sciences 308 (1985) 361-374
23. Fisher K., and Coderre T.J. The contribution of metabotropic glutamate receptors (mGluRs) to formalin-induced nociception. Pain 68 (1996) 255-263
24. Green G.M., and Dickenson A. GABA-receptor control of the amplitude and duration of the neuronal responses to formalin in the rat spinal cord. European Journal of Pain 1 (1997) 95-104
25. Gund P., and Shen T.Y. A model for the prostaglandin synthetase cyclooxygenation site and its inhibition by antiinflammatory arylacetic acids. Journal of Medical Chemistry 20 (1977) 1146-1152
26. Haghparast A., Soltani-Hekmat A., Khani A., and Komaki A. Role of glutamatergic receptors located in the nucleus raphe magnus on antinociceptive effect of morphine microinjected into the nucleus cuneiformis of rat. Neuroscience Letters 427 (2007) 44-49
27. Heinricher M.M., and Ingram S.L. The brainstem and nociceptive modulation. In: Bushnell M.C., and Basbaum A.I. (Eds). The Senses, a Comprehensive Reference. Pain (2008), Academic Press, San Diego 593-626
28. Heinricher M.M., and Neubert M.J. Neural basis for the hyperalgesic action of cholecystokinin in the rostral ventromedial medulla. Journal of Neurophysiology 92 (2004) 1982-1989
29. Heinricher M.M., and Tortorici V. Interference with GABA transmission in the rostral ventromedial medulla: disinhibition of off-cells as a central mechanism in nociceptive modulation. Neuroscience 63 (1994) 533-546
30. Henry J.L., Yashpal K., Pitcher G.M., and Coderre T.J. Physiological evidence that the 'interphase' in the formalin test is due to active inhibition. Pain 82 (1999) 57-63
31. Hunskaar S., and Hole K. The formalin test in mice: dissociation between inflammatory and non-inflammatory pain. Pain 30 (1987) 103-114
32. Jourdan D., Ardid D., Bardin L., Bardin M., Neuzeret D., Lanphouthacoul L., and Eschalier A. A new automated method of pain scoring in the formalin test in rats. Pain 71 (1997) 265-270
33. Kim D., Park D., Choi S., Lee S., Sun M., Kim C., and Shin H.S. Thalamic control of visceral nociception mediated by T-type Ca2+ channels. Science 302 (2003) 117-119
34. Kincaid W., Neubert M.J., Xu M., Kim C.J., and Heinricher M.M. Role for medullary pain facilitating neurons in secondary thermal hyperalgesia. Journal of Neurophysiology 95 (2006) 33-41
35. Lakos S., and Basbaum A.I. An ultrastructural study of the projections from the midbrain periaqueductal gray to spinally projecting, serotonin-immunoreactive neurons of the medullary nucleus raphe magnus in the rat. Brain Research 443 (1988) 383-388
36. Le Bars D., Gozariu M., and Cadden S.W. Animal models of nociception. Pharmacological Reviews 53 (2001) 597-652
37. Luraschi E., Arena F., Sacchi A., Laneri S., Abignente E., Avallone L., D'Amico M., Berrino L., and Rossi F. Research on heterocyclic compounds. XXXVIII. Synthesis and pharmacological activity of imidazo[1,2-b]pyridazine-2-carboxylic derivatives. Farmaco 52 (1997) 213-217
38. Malmberg A.B., and Yaksh T.L. Antinociceptive actions of spinal nonsteroidal anti-inflammatory agents on the formalin test in the rat. Journal of Pharmacology and Experimental Therapeutics 263 (1992) 136-146
39. Matthies B.K., and Franklin K.B. Formalin pain is expressed in decerebrate rats but not attenuated by morphine. Pain 51 (1992) 199-206
40. Mitchell D., and Hellon R.F. Neuronal and behavioural responses in rats during noxious stimulation of the tail. Proceedings of the Royal Society B: Biological Sciences 197 (1977) 169-194
41. Neubert M.J., Kincaid W., and Heinricher M.M. Nociceptive facilitating neurons in the rostral ventromedial medulla. Pain 110 (2004) 158-165
42. Odeh F., Antal M., and Zagon A. Heterogeneous synaptic inputs from the ventrolateral periaqueductal gray matter to neurons responding to somatosensory stimuli in the rostral ventromedial medulla of rats. Brain Research 959 (2003) 287-294
43. Oliva P., Berrino L., de Novellis V., Palazzo E., Marabese I., Siniscalco D., Scafuro M., Mariani L., Rossi F., and Maione S. Role of periaqueductal grey prostaglandin receptors in formalin-induced hyperalgesia. European Journal of Pharmacology 530 (2006) 40-47
44. Paxinos G., and Watson C. The Rat Brain in Stereotaxic Coordinates (1986), Academic Press, London
45. Pertovaara A. A neuronal correlate of secondary hyperalgesia in the rat spinal dorsal horn is submodality selective and facilitated by supraspinal influence. Experimental Neurology 149 (1998) 193-202
46. Pertovaara A., Wei H., and Hämäläinen M.M. Lidocaine in the rostroventromedial medulla and the periaqueductal gray attenuates allodynia in neuropathic rats. Neuroscience Letters 218 (1996) 127-130
47. Pomeroy S.L., and Behbehani M.M. Physiologic evidence for a projection from periaqueductal gray to nucleus raphe magnus in the rat. Brain Research 176 (1979) 143-147
48. Reichling D.B., Kwiat G.C., and Basbaum A.I. Anatomy, physiology and pharmacology of the periaqueductal gray contribution to antinociceptive controls. Progress in Brain Research 77 (1988) 31-46
49. Rimoli M.G., Russo E., Castaldi M., Citrato R., Ambrosino P., Melisi D., Curcio A., De Lucia S., Patrignani P., De Sarro G., and Abignente E. T-Type channel blocking properties and antiabsence activity of two imidazo[1,2-b]pyridazine derivatives structurally related to indomethacin. Neuropharmacology 56 (2009) 637-646
50. Rosland J.H., Tjølsen A., Maehle B., and Hole K. The formalin test in mice: effect of formalin concentration. Pain 42 (1990) 235-242
51. Sandkühler J., and Gebhart G.F. Relative contributions of the nucleus raphe magnus and adjacent medullary reticular formation to the inhibition by stimulation in the periaqueductal gray of a spinal nociceptive reflex in the pentobarbital-anesthetized rat. Brain Research 305 (1984) 77-87
52. Sawynok J., and Liu X.J. The formalin test: characteristics and usefulness of the model. Reviews in Analgesia 7 (2004) 143-163
53. Shah Y., and Dostrovsky J.O. Electrophysiological evidence for a projection of the periaqueductal gray matter to nucleus raphe magnus in cat and rat. Brain Research 193 (1980) 534-538
54. Shibata M., Ohkubo T., Takahashi H., and Inoki R. Modified formalin test: characteristic biphasic pain response. Pain 38 (1989) 347-352
55. Tjølsen A., Berge O.G., Hunskaar S., Rosland J.H., and Hole K. The formalin test: an evaluation of the method. Pain 51 (1992) 5-17
56. Todorovic S.M., and Jevtovic-Todorovic V. The role of T-type calcium channels in peripheral and central pain processing. CNS Neurological Disorders-Drug Targets 5 (2006) 639-653
57. Trevisani M., Siemens J., Materazzi S., Bautista D.M., Nassini R., Campi B., Imamachi N., Andrè E., Patacchini R., Cottrell G.S., Gatti R., Basbaum A.I., Bunnett N.W., Julius D., and Geppetti P. 4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1. Proceeding of the National Academy of Sciences of the United States America 104 (2007) 13519-13524
58. Urban M.O., and Smith D.J. Nuclei within the rostral ventromedial medulla mediating morphine antinociception from the periaqueductal gray. Brain Research 652 (1994) 9-16
59. Wang Q.P., and Nakai Y. The dorsal raphe: an important nucleus in pain modulation. Brain Research Bulletin 34 (1994) 575-585
60. Xu M., Kim C.J., Neubert M.J., and Heinricher M.M. NMDA receptor-mediated activation of medullary pro-nociceptive neurons is required for secondary thermal hyperalgesia. Pain 127 (2007) 253-262
61. Yashpal K., and Coderre T.J. Influence of formalin concentration on the antinociceptive effects of anti-inflammatory drugs in the formalin test in rats: separate mechanisms underlying the nociceptive effects of low- and high-concentration formalin. European Journal of Pain 2 (1998) 63-68
62. Zemlan F.P., and Behbehani M.M. Nucleus cuneiformis and pain modulation: anatomy and behavioral pharmacology. Brain Research 453 (1988) 89-102