Compact, rugged, and inexpensive frequency-domain fluorometer

Proceedings of SPIE - The International Society for Optical Engineering

Volumn 2980, Issue , 1997, Pages 81-89

  Levy, Ralph ^a   Guignon, Ernest F ^a   Cobane, Sean ^a   St Louis, Ernest ^a   Fernandez, Salvador M ^a  

^a Ciencia Inc   (United States)

Author keywords

Biosensor; Cross correlation; Fiber optic; Fluorescence; Fluorometer; Laser diode; Lifetime; Phase; Single sideband

Indexed keywords

BIOSENSORS; FIBER OPTIC SENSORS; FIBER OPTICS; FLUOROMETERS; FLUOROPHORES; OPTICAL SENSORS; PHOTOBLEACHING; SENSORS; TURBIDITY;

ANALYTE; CONTROLLED LABORATORIES; CROSS-CORRELATION; DETECTOR SENSITIVITIES; DO-MAINS; EMISSION INTENSITIES; FLUORESCENCE LIFETIMES; FLUORESCENCE SENSORS; FLUOROPHORE CONCENTRATIONS; HIGH COSTS; HIGH SENSITIVITIES; INTENSITY MEASUREMENTS; LIFE-TIMES; LIFETIME; LIFETIME MEASUREMENTS; LIGHT INTENSITIES; MICROENVIRONMENT; OPTIC SENSORS; OPTICAL DENSITIES; OPTICAL SURFACES; PHASE; PRACTICAL IMPLEMENTATIONS; PROMISING APPROACHES; SENSOR APPLICATIONS; SINGLE-SIDEBAND;

FLUORESCENCE;

EID: 7344243397     PISSN: 0277786X     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1117/12.273571     Document Type: Conference Paper

References (19)

1. Lakowicz, J.R. "Emerging Biomedical Applications of Time-Resolved Fluorescence Spectroscopy" in Topics in Fluorescence Spectroscopy: Probe Design and Chemical Sensing, J.R. Lakowicz, Ed., Vol. 4, pp. 1-19. Plenum Press, New York.
2. Szmacinski, H. and Lakowicz, J.R. "Lifetime-Based Sensing" in Topics in Fluorescence Spectroscopy: Probe Design and Chemical Sensing, J.R. Lakowicz, Ed., Vol. 4, pp. 295-334. Plenum Press, New York.
3. Bambot, S.B., Lakowicz, J.R. and Rao, Govind. "Potential Applications of Lifetime-Based, Phase-Modulation fluorimetry in Bioprocess and Clinical Monitoring", TIBTECH, 13, 106-115, 1995.
4. Thompson, R.B., Ge, Z., Patchan, M.W. and Fierke, C.A.. "Performance Enhancement of Fluorescence Energy Transfer-Based Biosensors by Site-Directed Mutagenesis ofthe Transducer", J. Biomed. Optics, 1, 131-137, 1996.
5. Birch, D.J.S., Rolinski, O.J. and Hatrick, D. "Fluorescence Lifetime Sensor of Copper Ions in Water", Rev. Sci. Instrum. 67, 2732-2737, 1996.
6. Lakowicz, J.R. and B. Maliwal "Optical Sensing of Glucose Using Phase-Modulation Fluorimetry", Anal. Chim. Acta., 271, 155-164, 1993.
7. 2 Phase Fluorometric Sensors". J. Biomed. Optics, 1, 124-130. 1996.
8. Ozinskas, A.J., Malak, H., Joshi, J., Szmacinski, H., Britz, J., Thompson, R.B., Koen, P.A. and Lakowicz, J.R. "Homogeneous Model Immunoassay of Thyroxine by Phase-Modulation Fluorescence Spectroscopy", Anal. Biochemistry, 213, 264-270, 1993.
9. Szmacisnki, H. and Lakowicz, J.R. "Optical Measurements ofpH Using Fluorescence Lifetimes and Phase-Modulation Fluorometry", Anal. Chem., 65, 1668-1674, 1993.
10. Anghel, F., Iliescu, C., Grattan, K.T.V., Palmer, A.W. and Zhang, Z.Y. "Fluorescent-Based Lifetime Measurement Thermometer for Use at Subroom Temperatures (200-300 K)", Rev. Sci. Instrum. 66, 2611-2614, 1995.
11. Sevick-Muraca, E.M., Hutchinson, C.L. and Paithankar, D.Y. "Optical Tissue Biodiagnostics Using Fluorescence Lifetime" Optics and Photonics News, January 1996, pp. 24-45.
12. Soper, S.A., Legendre, B.L. and Williams, D.C. "On-Line Fluorescence Lifetime Determinations in Capillary Electrophoresis", Anal. Chem., 67, 4358-4365, 1995.
13. Legendre, B.L., Williams, D.C. and Soper, S.A. "An All Solid-State Near-Infrared Time-Correlated Single Photon Counting Instrument for Dynamic Lifetime Measurements in DNA Sequencing Applications", Rev. Sci. Instrum., 67, 3984-3989, 1996.
14. 2+ concentration using quin-2 fluorescence. Phtochem. Photobiol., 53, 415-418, 1991.
15. Mank, A.J.G., van der Laan, H.T.C., Lingeman, H., Goojier, C., Brinkman, U.A. Th. And Velthorst, N.H. "Visible Diode Laser-Induced Fluorescence Detection in Liquid Chromatography after Precolumn Derivatization of Amines", Anal. Chem., 67, 1742-1748, 1995.
16. Shealy, D.B., Lipowska, M., Lipowski, J., Narayanan, N., Suffer, S., Strekowski, L. and Patonay, G. "Synthesis, Chromatographic Separation, and Characterization of Near-Infrared-Labeled DNA Oligomers for Use in DNA Sequencing", Anal. Chem., 67, 247-251, 1995.
17. Legendre, B.L. and Soper, S.A. "Binding Properties of Near-IR Dyes to Proteins and Separation of the Dye/Protein Complexes Using Capillary Electrophoresis with Laser-Induces Fluorescence Detection", Appl. Spectroscopy, 50, 1196-1202, 1996.
18. Thompson, R.B., Frisoli, J.K. and Lakowicz, J.R. "Phase Fluorometry Using Continuously Modulated Laser Diode", Anal. Chem., 64, 2075-2078, 1992.
19. Spencer, J. and Weber, G. "Measurement of Sub-nanosecond Fluorescence Lifetime with a Cross-Correlation Phase Fluorometer" Ann. New York Acad. Sci. p361, 1969.