Development of a validated RP-HPLC method for separation and determination of process-related impurities of omeprazole in bulk drugs

Farmacia

Volumn 57, Issue 5, 2009, Pages 534-541

  Iuga, Cristina ^a   Bojiţǎ, Marius ^a   Leucuţa, Sorin E ^a  

^a IULIU HATIEGANU UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

Author keywords

Omeprazole; Process related impurities; RP HPLC; Validation

Indexed keywords

2 [(3,5 DIMETHYLPYRIDIN 2 YL)METHYL]SULPHINYL 5 METHOXY 1H BENZIMIDAZOLE; 4 METHOXY 2 [[(5 METHOXY 1H BENZIMIDAZOL 2 YL)SULPHINYL]METHYL] 3,5 DIMETHYLPYRIDINE 1 OXIDE; 5 METHOXY 1H BENZIMIDAZOLE 2 THIOL; 5 METHOXY 2 [[(4 CHLORO 3,5 DIMETHYLPYRIDIN 2 YL)METHYL]SULPHINYL] 1H BENZIMIDAZOLE; BENZIMIDAZOLE DERIVATIVE; OMEPRAZOLE; OMEPRAZOLE SULFONE; UFIPRAZOLE; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; CALIBRATION; DRUG IMPURITY; DRUG STRUCTURE; LIQUID CHROMATOGRAPHY; PH; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SEPARATION TECHNIQUE; ULTRAVIOLET RADIATION;

EID: 73349117471     PISSN: 00148237     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (5)

1. Espinosa Bosh M, Ruiz Sanchez A.J., Sanchez Rojas F., Bosch Ojeda C. Analytical methodologies for the determination of omeprazole: An overview. Journal of Pharmaceutical and Biomedical Analysis 2007; 44: 831-844.
2. Varvara A., Monciu C.M, Arama C., Popescu C. The HPLC assay of ondansetron hydrochloride and its impurities using a new stationary phase. Farmacia 2008; 56 (2):154-165.
3. Constantinescu D., Curea E. Reversed phase high performance liquid chromatography (RP-HPLC) determination of lisinopril and its degradation products in stability and compatibility studies. Farmacia 2008; 56 (1) :50-56.
4. Iuga C., Moldovan M., Popa A., Leucuţa S.E. Validation of HPLC-UV method for analysis of omeprazole in presence of its metabolites in human plasma. Farmacia, 2008, 56 (3): 254-260.
5. Ribani M, Collins CH, Bottoli CB. Validation of chromatographic methods: evaluation of detection and quantification limits in the determination of impurities in omeprazole. J Chromatogr A. 2007; (1156) 1-2:201-205.