Validation of HPLC-UV method for analysis of omeprazole in presence of its metabolistes in human plasma

Farmacia

Volumn 56, Issue 3, 2008, Pages 254-260

  Iuga, Cristina ^a   Moldovan, Mirela ^a   Popa, Adina ^a   Leucuta, S E ^a  

^a IULIU HATIEGANU UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

Author keywords

[No Author keywords available]

Indexed keywords

DICHLOROMETHANE; ETHER; OMEPRAZOLE; OMEPRAZOLE SULFONE; PHENACETIN; TRIETHYLAMINE;

ACCURACY; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG ISOLATION; DRUG STABILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LIQUID LIQUID EXTRACTION; METABOLITE; PH; REPRODUCIBILITY; SENSITIVITY ANALYSIS; SEPARATION TECHNIQUE; ULTRAVIOLET RADIATION; VALIDATION PROCESS;

EID: 45949108485     PISSN: 00148237     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (5)

1. Kobayashi K., Chiba K., Sohn D.S, Kato I., Ishizaki T. Simultaneous determination of omeprazole and its metabolites in plasma and urine by reversed-phase high-performance liquid chromatography with an alkalin resistant polymer coated C18 column. J. of Chromatography B 1992; 579:299-305
2. Leucuta A., Farcau D., Iuga C., Draghiciu D., Nanulescu M., Leucuta S.E. Analiza compartimentalǎ şi noncompartimentalǎ a farmacocineticii omeprazolului la copii şi adulţi. Terapeuticǎ, Farmacologie şi Toxicologie Clinicǎ, 2004, 8,(2), 100-103
3. Leucuta S.E., Iuga C, Capalneanu R., Popa A., Preda M. Determinarea bioechivalenţei a douǎ preparate cu omeprazol: Omeran (Europharm) si Losec (Astra). Terapeuticǎ, Farmacologie şi Toxicologie clinicǎ, 2002, 6(3), 101-103
4. Macek J., Ptacek P., Klima J. Determination of omeprazole in human plasma by high-performance liquid chromatography. J. of Chromatography B, 1997; 689:239-243
5. US Food and Drug Administration. Guidance for Industry: Bioanalytical Method Validation, 2001 http://www.fda.gov/cder/guidance/4252fnl.htm