Inhibition of phosphatidylinositol 3-kinase/akt signaling suppresses tumor cell proliferation and neuroendocrine marker expression in GI carcinoid tumors

Annals of Surgical Oncology

Volumn 16, Issue 10, 2009, Pages 2936-2942

  Pitt, Susan C ^a   Chen, Herbert ^a   Kunnimalaiyaan, Muthusamy ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CHROMOGRANIN A; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN KINASE B BETA; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR MASH1; TUMOR MARKER; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; CHROMONE DERIVATIVE; MORPHOLINE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CANCER INHIBITION; CONTROLLED STUDY; DOSE RESPONSE; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GASTROINTESTINAL CARCINOMA; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; CARCINOID; CELL PROLIFERATION; DRUG ANTAGONISM; DRUG EFFECT; GASTROINTESTINAL TUMOR; GENETICS; METABOLISM; NEUROENDOCRINE TUMOR; PATHOLOGY; PHENOTYPE; PHOSPHORYLATION; TUMOR CELL CULTURE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; BLOTTING, WESTERN; CARCINOID TUMOR; CELL PROLIFERATION; CHROMOGRANIN A; CHROMONES; GASTROINTESTINAL NEOPLASMS; HUMANS; MORPHOLINES; NEUROENDOCRINE TUMORS; PHENOTYPE; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL;

EID: 73349098231     PISSN: 10689265     EISSN: 15344681     Source Type: Journal    
DOI: 10.1245/s10434-009-0591-5     Document Type: Article

References (26)

1. Modlin IM, Lye KD, Kidd M. A5-decade analysis of 13,715 carcinoid tumors. Cancer. 2003;97:934-59.
2. Sippel RS, Carpenter JE, Kunnimalaiyaan M, Langerholm S, Chen H. Raf-1 activation suppresses neuroendocrine marker and hormone levels in human gastrointestinal carcinoid cells. Am J Physiol Gastrointest Liver Physiol. 2003;285:G245-54.
3. Chen H, Hardcare JM, Uzar A, Cameron JL, Choti M. Isolated liver metastases from neuroendocrine tumors: does resection prolong survival? JAm Coll Surg. 1998;187:88-92.
4. Touzous JG, Keily JM, Pitt SC, Rilling WS, Quebbeman EJ, Wilson SD, et al. Neuroendocrine hepatic metastases: dose aggressive management improve survival? Annals Surg. 2005; 241:776-83.
5. Musunuru S, Chen H, Rajapal S, Stephani N, McDermott JC, Holen K, et al. Metastatic neuroendocrine hepatic tumors: resection improves survival. Arch Surg. 2006;141:1000-4.
6. Van Gompel JJ, Sippel RS, Warner TF, Chen H. Gastrointestinal carcinoid tumors: factors that predict outcome. World J Surg. 2004;28:387-92.
7. Miller CA, Ellison EC Therapeutic alternatives in metastatic neuroendocrine tumors. Surg Oncol Clin N Am. 1998;7:863-79.
8. Kunninmalaiyaan M, Chen H. The raf-1 pathway: a molecular target for treatment of select neuroendocrine tumors? Anticancer Drugs. 2006;17:139-42.
9. Van Gompel JJ, Kunnimalaiyaan M, Holen K, Chen H. ZM336372, a Raf-1 activator, suppresses growth and neuroen-docrine hormone levels in carcinoid tumor cells. Mol Cancer Ther. 2005;4:910-7.
10. Kunnimalaiyaan M, Traeger K, Chen H. Conservation of the Notch1 signaling pathway in gastrointestinal carcinoid cells. Am J Physiol Gastrointest Liver Physiol. 2005;289:G636-42.
11. Greenblatt DY, Cayo M, Ning L, Jaskula-Sztul R, Haymart M, Kunnimalaiyaan M, et al. Suberoyl bishydroxamic acid inhibits cellular proliferation by inducing cell cycle arrest in carcinoid tumor cancer cells. J Gastrointest Surg. 2007;11:1515-21.
12. Kunninmalaiyaan M, Vaccaro AM, Ndiaye M, Chen H. Over-expression of the NOTCH1 intracellular domain inhibits cell proliferation and alters the neuroendocrine phenotype of medul-lary thyroid cancer cells. J Biol Chem. 2006;281:39819-30.
13. Kunninmalaiyaan M, Ndiaye M, Chen H. Apoptosis-mediated medullary thyroid cancer growth suppression by the PI3 K inhibitor LY294002. Surgery. 2006;140:1009-15.
14. Luo J, Manning BD, Cantley LC Targeting the PI3 K-Akt pathway in human cancer: rationale and promise. Cancer Cell. 2003;4:257-62.
15. Wang L, Ignat A, Anxiotis CA. Differential expression of the PTEN tumor suppressor protein in fetal and adult neuroendocrine tissues and tumors: progressive loss of PTEN expression in poorly differentiated neuroendocrine neoplasms. Appl Immuno-histochem Mol Morpol. 2002;10:139-46.
16. Shah T, Hochhauser D, Frow R, Quaglia A, Dhillon AP, Caplin ME. Epidermal growth factor receptor expression and activation in neuroendocrine tumors. J Neuroendocrinol. 2006;18:355-60.
17. Evers BM, Townsend CM Jr, Upp JR, Allen E, Hurlbut SC, Kim SW, et al. Establishment and characterization of a human carci-noid in nude mice and effect of various agents on tumor growth. Gastroenterology. 1991;101:303-11.
18. Vlahos CJ, Matter WF, Hui KY, Brown RF. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J Biol Chem. 1994;269: 5241-8.
19. Mandal M, Younes M, Swan EA, Jasser SA, Doan D, Yigitbasi O, et al. The Akt inhibitor KP372-1 inhibits proliferation and induces apoptosis and anoikis in squamous cell carcinoma of the head and neck. Oral Oncol. 2006;42:430-9.
20. Morgan DO. Principles of CDK regulation. Nature. 1995;372: 131-4.
21. + ̄̄ mice. Genes Dev. 2006;20:1569-74.
22. Liu H, Radisky DC, Nelson CM, Zhang H, Fata JE, Roth RA, et al. Mechanism ofAkt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2. PNAS. 2006;103:4134-9.
23. Tang HJ, Jin X, Wang S, Yang D, Cao Y, Chen J, et al. A small molecule compound inhibits AKT pathway in ovarian cancer cell lines. Gynecol Oncol. 2006;100:308-17.
24. Wu C, Huang J. Phosphatidylinositol 3-kinase-AKT-mammalian target of rapapmycin pathway is essential for neuroendocrine differentiation of prostate cancer. J Biol Chem. 2007;282:3571-83.
25. von Wichert G, Haeussler U, Greten FR, Kliche S, Dralle H, Böhm BO, et al. Regulation of cyclin D1 expression by autocrine IGF-1 in human BON neuroendocrine tumor cells. Oncogene. 2005;24:1284-9.
26. Dufourny B, van Teeffelen HA, Hamelers IH, Sussenbach JS, Steenbergh PH. Stabilization of cyclin D1 mRNA via the phos-phatidylinositol 3-kinase pathway in MCF-7 human breast cancer cells. J Endocrinol. 2000;166:329-38.