Infiltration of water molecules into the oseltamivir-binding site of H274Y neuraminidase mutant causes resistance to oseltamivir

Journal of Chemical Information and Modeling

Volumn 49, Issue 12, 2009, Pages 2735-2741

  Park, Jin Woo ^a   Jo, Won Ho ^a  

^a Seoul National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

AEROSPACE VEHICLES; FREE ENERGY; MOLECULAR DYNAMICS; MOLECULES;

ACTIVE SITE RESIDUES; BINDING FREE ENERGY; INTERACTION ENERGIES; MOLECULAR DYNAMICS SIMULATIONS; MOLECULAR DYNAMICS TRAJECTORIES; MOLECULAR LEVELS; NEURAMINIDASE INHIBITORS; NONBONDED INTERACTION;

BINDING ENERGY;

ANTIVIRUS AGENT; MUTANT PROTEIN; OSELTAMIVIR; SIALIDASE; WATER;

ANTIVIRAL RESISTANCE; ARTICLE; BINDING SITE; CHEMISTRY; CONFORMATION; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENETICS; INFLUENZA VIRUS A H1N1; INFLUENZA VIRUS A H5N1; METABOLISM; MOLECULAR DYNAMICS; MUTATION; THERMODYNAMICS;

ANTIVIRAL AGENTS; BINDING SITES; DRUG RESISTANCE, VIRAL; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA A VIRUS, H5N1 SUBTYPE; MOLECULAR CONFORMATION; MOLECULAR DYNAMICS SIMULATION; MUTANT PROTEINS; MUTATION; NEURAMINIDASE; OSELTAMIVIR; THERMODYNAMICS; WATER;

EID: 73349096620     PISSN: 15499596     EISSN: 1549960X     Source Type: Journal    
DOI: 10.1021/ci900348n     Document Type: Article

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