-
1
-
-
0036851826
-
Vascular proliferation and atherosclerosis: New perspectives and therapeutic strategies
-
Dzau VJ, Braun-Dullaeus RC, Sedding DG. Vascular proliferation and atherosclerosis: new perspectives and therapeutic strategies. Nat Med. 2002;8:1249-1256
-
(2002)
Nat Med
, vol.8
, pp. 1249-1256
-
-
Dzau, V.J.1
Braun-Dullaeus, R.C.2
Sedding, D.G.3
-
2
-
-
42549118722
-
No HOPE without proof do ARBs meet the standard for cardiovascular protection?
-
Sleight P, Jakobsen A, Heroys J, Ralph A, Rees T, Shaw M. No HOPE without proof: do ARBs meet the standard for cardiovascular protection? Medscape J Med. 2008;10(suppl):S6
-
(2008)
Medscape J Med
, vol.10
, Issue.SUPPL.
-
-
Sleight, P.1
Jakobsen, A.2
Heroys, J.3
Ralph, A.4
Rees, T.5
Shaw, M.6
-
3
-
-
1542547460
-
Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPARgamma-modulating activity
-
Benson SC, Pershadsingh HA, Ho CI, Chittiboyina A, Desai P, Pravenec M, Qi N, Wang J, Avery MA, Kurtz TW. Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPARgamma-modulating activity. Hypertension. 2004;43:993-1002
-
(2004)
Hypertension
, vol.43
, pp. 993-1002
-
-
Benson, S.C.1
Pershadsingh, H.A.2
Ho, C.I.3
Chittiboyina, A.4
Desai, P.5
Pravenec, M.6
Qi, N.7
Wang, J.8
Avery, M.A.9
Kurtz, T.W.10
-
4
-
-
33644672013
-
Molecular characterization of new selective peroxisome proliferator-activated receptor gamma modulators with angiotensin receptor blocking activity
-
Schupp M, Clemenz M, Gineste R, Witt H, Janke J, Helleboid S, Hennuyer N, Ruiz P, Unger T, Staels B, Kintscher U. Molecular characterization of new selective peroxisome proliferator-activated receptor gamma modulators with angiotensin receptor blocking activity. Diabetes. 2005;54:3442-3452
-
(2005)
Diabetes
, vol.54
, pp. 3442-3452
-
-
Schupp, M.1
Clemenz, M.2
Gineste, R.3
Witt, H.4
Janke, J.5
Helleboid, S.6
Hennuyer, N.7
Ruiz, P.8
Unger, T.9
Staels, B.10
Kintscher, U.11
-
5
-
-
2442451618
-
Angiotensin type 1 receptor blockers induce peroxisome proliferator-activated receptor-gamma activity
-
Schupp M, Janke J, Clasen R, Unger T, Kintscher U. Angiotensin type 1 receptor blockers induce peroxisome proliferator-activated receptor-gamma activity. Circulation. 2004;109:2054-2057
-
(2004)
Circulation
, vol.109
, pp. 2054-2057
-
-
Schupp, M.1
Janke, J.2
Clasen, R.3
Unger, T.4
Kintscher, U.5
-
6
-
-
21744452983
-
PPARgamma-activating angiotensin type-1 receptor blockers induce adiponectin
-
Clasen R, Schupp M, Foryst-Ludwig A, Sprang C, Clemenz M, Krikov M, Thone-Reineke C, Unger T, Kintscher U. PPARgamma-activating angiotensin type-1 receptor blockers induce adiponectin. Hypertension. 2005;46:137-143
-
(2005)
Hypertension
, vol.46
, pp. 137-143
-
-
Clasen, R.1
Schupp, M.2
Foryst-Ludwig, A.3
Sprang, C.4
Clemenz, M.5
Krikov, M.6
Thone-Reineke, C.7
Unger, T.8
Kintscher, U.9
-
7
-
-
38549161568
-
Telmisartan inhibits CD4-positive lymphocyte migration independent of the angiotensin type 1 receptor via peroxisome proliferator-activated receptor-gamma
-
Walcher D, Hess K, Heinz P, Petscher K, Vasic D, Kintscher U, Clemenz M, Hartge M, Raps K, Hombach V, Marx N. Telmisartan inhibits CD4-positive lymphocyte migration independent of the angiotensin type 1 receptor via peroxisome proliferator-activated receptor-gamma. Hypertension. 2008;51: 259-266
-
(2008)
Hypertension
, vol.51
, pp. 259-266
-
-
Walcher, D.1
Hess, K.2
Heinz, P.3
Petscher, K.4
Vasic, D.5
Kintscher, U.6
Clemenz, M.7
Hartge, M.8
Raps, K.9
Hombach, V.10
Marx, N.11
-
8
-
-
39749201501
-
Effect of telmisartan on nitric oxide-asymmetrical dim-ethylarginine system: Role of angiotensin II type 1 receptor gamma and peroxisome proliferator activated receptor gamma signaling during endo-thelial aging
-
Scalera F, Martens-Lobenhoffer J, Bukowska A, Lendeckel U, Tager M, Bode-Boger SM. Effect of telmisartan on nitric oxide-asymmetrical dim-ethylarginine system: role of angiotensin II type 1 receptor gamma and peroxisome proliferator activated receptor gamma signaling during endo-thelial aging. Hypertension. 2008;51:696-703
-
(2008)
Hypertension
, vol.51
, pp. 696-703
-
-
Scalera, F.1
Martens-Lobenhoffer, J.2
Bukowska, A.3
Lendeckel, U.4
Tager, M.5
Bode-Boger, S.M.6
-
9
-
-
33646148948
-
Telmisartan but not valsartan increases caloric expenditure and protects against weight gain and hepatic steatosis
-
Sugimoto K, Qi NR, Kazdova L, Pravenec M, Ogihara T, Kurtz TW. Telmisartan but not valsartan increases caloric expenditure and protects against weight gain and hepatic steatosis. Hypertension. 2006;47: 1003-1009
-
(2006)
Hypertension
, vol.47
, pp. 1003-1009
-
-
Sugimoto, K.1
Qi, N.R.2
Kazdova, L.3
Pravenec, M.4
Ogihara, T.5
Kurtz, T.W.6
-
10
-
-
42049108222
-
Inhibition of cardiovascular cell proliferation by angiotensin receptor blockers are all molecules the same?
-
Benson SC, Iguchi R, Ho CI, Yamamoto K, Kurtz TW. Inhibition of cardiovascular cell proliferation by angiotensin receptor blockers: are all molecules the same? J Hypertens. 2008;26:973-980
-
(2008)
J Hypertens
, vol.26
, pp. 973-980
-
-
Benson, S.C.1
Iguchi, R.2
Ho, C.I.3
Yamamoto, K.4
Kurtz, T.W.5
-
11
-
-
11244253710
-
GW9662, a potent antagonist of PPARgamma, inhibits growth of breast tumour cells and promotes the anticancer effects of the PPARgamma agonist rosiglitazone, independently of PPARgamma activation
-
Seargent JM, Yates EA, Gill JH. GW9662, a potent antagonist of PPARgamma, inhibits growth of breast tumour cells and promotes the anticancer effects of the PPARgamma agonist rosiglitazone, independently of PPARgamma activation. Br J Pharmacol. 2004;143:933-937
-
(2004)
Br J Pharmacol
, vol.143
, pp. 933-937
-
-
Seargent, J.M.1
Yates, E.A.2
Gill, J.H.3
-
12
-
-
0028641559
-
Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor
-
Tontonoz P, Hu E, Spiegelman BM. Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor. Cell. 1994;79:1147-1156
-
(1994)
Cell
, vol.79
, pp. 1147-1156
-
-
Tontonoz, P.1
Hu, E.2
Spiegelman, B.M.3
-
13
-
-
0035720442
-
Changes in expression of antioxidant enzymes affect cell-mediated LDL oxidation and oxidized LDL-induced apoptosis in mouse aortic cells
-
Guo Z, Van Remmen H, Yang H, Chen X, Mele J, Vijg J, Epstein CJ, Ho YS, Richardson A. Changes in expression of antioxidant enzymes affect cell-mediated LDL oxidation and oxidized LDL-induced apoptosis in mouse aortic cells. Arterioscler Thromb Vasc Biol. 2001;21:1131-1138
-
(2001)
Arterioscler Thromb Vasc Biol
, vol.21
, pp. 1131-1138
-
-
Guo, Z.1
Van Remmen, H.2
Yang, H.3
Chen, X.4
Mele, J.5
Vijg, J.6
Epstein, C.J.7
Ho, Y.S.8
Richardson, A.9
-
14
-
-
9144229185
-
Adipose-specific peroxisome proliferator-acti-vated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle
-
He W, Barak Y, Hevener A, Olson P, Liao D, Le J, Nelson M, Ong E, Olefsky JM, Evans RM. Adipose-specific peroxisome proliferator-acti-vated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle. Proc Natl Acad Sci U S A. 2003;100:15712-15717
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 15712-15717
-
-
He, W.1
Barak, Y.2
Hevener, A.3
Olson, P.4
Liao, D.5
Le Nelson J, M.6
Ong, E.7
Olefsky, J.M.8
Evans, R.M.9
-
15
-
-
34250788809
-
AKT/PKB signaling: Navigating downstream
-
Manning BD, Cantley LC. AKT/PKB signaling: navigating downstream. Cell. 2007;129:1261-1274
-
(2007)
Cell
, vol.129
, pp. 1261-1274
-
-
Manning, B.D.1
Cantley, L.C.2
-
16
-
-
0034997845
-
Mitogen-activated protein (MAP) kinase pathways: Regulation and physiological functions
-
Pearson G, Robinson F, Beers Gibson T, Xu BE, Karandikar M, Berman K, Cobb MH. Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr Rev. 2001;22:153-183
-
(2001)
Endocr Rev
, vol.22
, pp. 153-183
-
-
Pearson, G.1
Robinson, F.2
Beers Gibson, T.3
Xu, B.E.4
Karandikar, M.5
Berman, K.6
Cobb, M.H.7
-
17
-
-
62949206286
-
Mechanisms and functions of agonist-independent activation in the angiotensin II type 1 receptor
-
Akazawa H, Yasuda N, Komuro I. Mechanisms and functions of agonist-independent activation in the angiotensin II type 1 receptor. Mol Cell Endocrinol. 2009;302:140-147
-
(2009)
Mol Cell Endocrinol
, vol.302
, pp. 140-147
-
-
Akazawa, H.1
Yasuda, N.2
Komuro, I.3
-
18
-
-
33750602514
-
Angiotensin II signal transduction through small GTP-binding proteins: Mechanism and significance in vascular smooth muscle cells
-
Ohtsu H, Suzuki H, Nakashima H, Dhobale S, Frank GD, Motley ED, Eguchi S. Angiotensin II signal transduction through small GTP-binding proteins: mechanism and significance in vascular smooth muscle cells. Hypertension. 2006;48:534-540
-
(2006)
Hypertension
, vol.48
, pp. 534-540
-
-
Ohtsu, H.1
Suzuki, H.2
Nakashima, H.3
Dhobale, S.4
Frank, G.D.5
Motley, E.D.6
Eguchi, S.7
-
19
-
-
2942751868
-
Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II
-
Zou Y, Akazawa H, Qin Y, Sano M, Takano H, Minamino T, Makita N, Iwanaga K, Zhu W, Kudoh S, Toko H, Tamura K, Kihara M, Nagai T, Fukamizu A, Umemura S, Iiri T, Fujita T, Komuro I. Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II. Nat Cell Biol. 2004;6:499-506
-
(2004)
Nat Cell Biol
, vol.6
, pp. 499-506
-
-
Zou, Y.1
Akazawa, H.2
Qin, Y.3
Sano, M.4
Takano, H.5
Minamino, T.6
Makita, N.7
Iwanaga, K.8
Zhu, W.9
Kudoh, S.10
Toko, H.11
Tamura, K.12
Kihara, M.13
Nagai, T.14
Fukamizu, A.15
Umemura, S.16
Iiri, T.17
Fujita, T.18
Komuro, I.19
-
20
-
-
0037203546
-
Akt: Versatile mediator of cell survival and beyond
-
Kim D, Chung J. Akt: versatile mediator of cell survival and beyond. J Biochem Mol Biol. 2002;35:106-115
-
(2002)
J Biochem Mol Biol
, vol.35
, pp. 106-115
-
-
Kim, D.1
Chung, J.2
-
21
-
-
17144395975
-
The activation of Akt/PKB signaling pathway and cell survival
-
Song G, Ouyang G, Bao S. The activation of Akt/PKB signaling pathway and cell survival. J Cell Mol Med. 2005;9:59-71
-
(2005)
J Cell Mol Med
, vol.9
, pp. 59-71
-
-
Song, G.1
Ouyang, G.2
Bao, S.3
-
22
-
-
14944381279
-
Emerging role of Akt kinase/protein kinase B signaling in pathophysiology of diabetes and its complications
-
Zdychova J, Komers R. Emerging role of Akt kinase/protein kinase B signaling in pathophysiology of diabetes and its complications. Physiol Res. 2005;54:1-16
-
(2005)
Physiol Res
, vol.54
, pp. 1-16
-
-
Zdychova, J.1
Komers, R.2
-
23
-
-
42049107348
-
Telmisartan, ramipril, or both in patients at high risk for vascular events
-
Yusuf S, Teo KK, Pogue J, Dyal L, Copland I, Schumacher H, Dagenais G, Sleight P, Anderson C. Telmisartan, ramipril, or both in patients at high risk for vascular events. N Engl J Med. 2008;358:1547-1559
-
(2008)
N Engl J Med
, vol.358
, pp. 1547-1559
-
-
Yusuf, S.1
Teo, K.K.2
Pogue, J.3
Dyal, L.4
Copland, I.5
Schumacher, H.6
Dagenais, G.7
Sleight, P.8
Anderson, C.9
-
24
-
-
7444244389
-
NO-sartans: A new class of pharmacodynamic hybrids as cardiovascular drugs
-
Breschi MC, Calderone V, Digiacomo M, Martelli A, Martinotti E, Minutolo F, Rapposelli S, Balsamo A. NO-sartans: a new class of pharmacodynamic hybrids as cardiovascular drugs. J Med Chem. 2004;47: 5597-5600
-
(2004)
J Med Chem
, vol.47
, pp. 5597-5600
-
-
Breschi, M.C.1
Calderone, V.2
Digiacomo, M.3
Martelli, A.4
Martinotti, E.5
Minutolo, F.6
Rapposelli, S.7
Balsamo, A.8
-
25
-
-
34247581728
-
TAK-536, a new AT1 receptor blocker, improves glucose intolerance and adipocyte differentiation
-
Iwai M, Chen R, Imura Y, Horiuchi M. TAK-536, a new AT1 receptor blocker, improves glucose intolerance and adipocyte differentiation. Am J Hypertens. 2007;20:579-586
-
(2007)
Am J Hypertens
, vol.20
, pp. 579-586
-
-
Iwai, M.1
Chen, R.2
Imura, Y.3
Horiuchi, M.4
-
26
-
-
35449004560
-
WB1106, a novel nitric oxide-releasing derivative of telmisartan, inhibits hypertension and improves glucose metabolism in rats
-
Li YQ, Ji H, Zhang YH, Shi WB, Meng ZK, Chen XY, Du GT, Tian J. WB1106, a novel nitric oxide-releasing derivative of telmisartan, inhibits hypertension and improves glucose metabolism in rats. Eur J Pharmacol. 2007;577:100-108
-
(2007)
Eur J Pharmacol
, vol.577
, pp. 100-108
-
-
Li, Y.Q.1
Ji, H.2
Zhang, Y.H.3
Shi, W.B.4
Meng, Z.K.5
Chen, X.Y.6
Du, G.T.7
Tian, J.8
-
27
-
-
19944428321
-
Dual angiotensin II and endothelin A receptor antagonists: Synthesis of 2'-substituted N-3-isoxazolyl biphenylsulfonamides with improved potency and pharmacokinetics
-
Murugesan N, Gu Z, Fadnis L, Tellew JE, Baska RA, Yang Y, Beyer SM, Monshizadegan H, Dickinson KE, Valentine MT, Humphreys WG, Lan SJ, Ewing WR, Carlson KE, Kowala MC, Zahler R, Macor JE. Dual angiotensin II and endothelin A receptor antagonists: synthesis of 2'-substituted N-3-isoxazolyl biphenylsulfonamides with improved potency and pharmacokinetics. J Med Chem. 2005;48:171-179
-
(2005)
J Med Chem
, vol.48
, pp. 171-179
-
-
Murugesan, N.1
Gu, Z.2
Fadnis, L.3
Tellew, J.E.4
Baska, R.A.5
Yang, Y.6
Beyer, S.M.7
Monshizadegan, H.8
Dickinson, K.E.9
Valentine, M.T.10
Humphreys, W.G.11
Lan, S.J.12
Ewing, W.R.13
Carlson, K.E.14
Kowala, M.C.15
Zahler, R.16
MacOr, J.E.17
-
28
-
-
65249098027
-
Pre-clinical development of PS433540, a dual-acting receptor antagonist (DARA) of the angiotensin and endothelin receptors
-
Floyd DM, Sills MA. Pre-clinical development of PS433540, a dual-acting receptor antagonist (DARA) of the angiotensin and endothelin receptors. J Clin Hypertens (Greenwich). 2007;9(suppl A):A158
-
(2007)
J Clin Hypertens (Greenwich)
, vol.9
, Issue.SUPPL. A
-
-
Floyd, D.M.1
Sills, M.A.2
-
29
-
-
70349992023
-
A novel ARB with insulin-sensitizing activity, K-868, prevents diabetic nephropathy in rats
-
Hamaguchi A, Uchii M, Matsubara M, Yanagisawa A, Hemmi K, Ueno K, Kusaka H, Yao K. A novel ARB with insulin-sensitizing activity, K-868, prevents diabetic nephropathy in rats. Diabetes. 2009;58: A208-A209
-
(2009)
Diabetes
, vol.58
-
-
Hamaguchi, A.1
Uchii, M.2
Matsubara, M.3
Yanagisawa, A.4
Hemmi, K.5
Ueno, K.6
Kusaka, H.7
Yao, K.8
|