-
1
-
-
0030656430
-
Thiopurine drugs in the treatment of childhood leukaemia: The influence of inherited thiopurine methyltransferase activity on drug metabolism and cytotoxicity
-
Lennard, L., Welch, J. C. and Lilleyman, J. S.: Thiopurine drugs in the treatment of childhood leukaemia: the influence of inherited thiopurine methyltransferase activity on drug metabolism and cytotoxicity. Br. J. Clin. Pharmacol., 44: 455-461 (1997).
-
(1997)
Br. J. Clin. Pharmacol
, vol.44
, pp. 455-461
-
-
Lennard, L.1
Welch, J.C.2
Lilleyman, J.S.3
-
2
-
-
45849107951
-
Clinical pharmacology and pharmacogenetics of thiopurines
-
Sahasranaman, S., Howard, D. and Roy, S.: Clinical pharmacology and pharmacogenetics of thiopurines. Eur. J. Clin. Pharmacol., 64: 753-767 (2008).
-
(2008)
Eur. J. Clin. Pharmacol
, vol.64
, pp. 753-767
-
-
Sahasranaman, S.1
Howard, D.2
Roy, S.3
-
3
-
-
0036668038
-
Azathioprine therapy and adverse drug reactions in patients with inflammatory bowel disease: Impact of thiopurine S-methyltransferase polymorphism
-
Schwab, M., Schaffeler, E., Marx, C., Fischer, C., Lang, T., Behrens, C., Gregor, M., Eichelbaum, M., Zanger, U. M. and Kaskas, B. A.: Azathioprine therapy and adverse drug reactions in patients with inflammatory bowel disease: impact of thiopurine S-methyltransferase polymorphism. Pharmacogenetics, 12: 429-436 (2002).
-
(2002)
Pharmacogenetics
, vol.12
, pp. 429-436
-
-
Schwab, M.1
Schaffeler, E.2
Marx, C.3
Fischer, C.4
Lang, T.5
Behrens, C.6
Gregor, M.7
Eichelbaum, M.8
Zanger, U.M.9
Kaskas, B.A.10
-
4
-
-
0036790212
-
Thiopurine methyltransferase activity and the use of azathioprine in inflammatory bowel disease
-
Ansari, A., Hassan, C., Duley, J., Marinaki, A., Shobowale-Bakre, E. M., Seed, P., Meenan, J., Yim, A. and Sanderson, J.: Thiopurine methyltransferase activity and the use of azathioprine in inflammatory bowel disease. Aliment. Pharmacol. Ther., 16: 1743-1750 (2002).
-
(2002)
Aliment. Pharmacol. Ther
, vol.16
, pp. 1743-1750
-
-
Ansari, A.1
Hassan, C.2
Duley, J.3
Marinaki, A.4
Shobowale-Bakre, E.M.5
Seed, P.6
Meenan, J.7
Yim, A.8
Sanderson, J.9
-
5
-
-
0036076821
-
TPMT in the treatment of Crohn's disease with azathioprine
-
Lennard, L.: TPMT in the treatment of Crohn's disease with azathioprine. Gut., 51: 143-146 (2002).
-
(2002)
Gut
, vol.51
, pp. 143-146
-
-
Lennard, L.1
-
6
-
-
0026758498
-
The clinical pharmacology of 6-mercaptopurine
-
Lennard, L.: The clinical pharmacology of 6-mercaptopurine. Eur. J. Clin. Pharmacol., 43: 329-339 (1992).
-
(1992)
Eur. J. Clin. Pharmacol
, vol.43
, pp. 329-339
-
-
Lennard, L.1
-
7
-
-
0016053706
-
A biochemical mechanism for the delayed cytotoxic reaction of 6-mercaptopurine
-
Tidd, D. M. and Paterson, A. R.: A biochemical mechanism for the delayed cytotoxic reaction of 6-mercaptopurine. Cancer Res., 34: 738-746 (1974).
-
(1974)
Cancer Res
, vol.34
, pp. 738-746
-
-
Tidd, D.M.1
Paterson, A.R.2
-
8
-
-
33747377769
-
Review article: Thiopurines in inflammatory bowel disease
-
Derijks, L. J., Gilissen, L. P., Hooymans, P. M. and Hommes, D. W.: Review article: thiopurines in inflammatory bowel disease. Aliment. Pharmacol. Ther., 24: 715-729 (2006).
-
(2006)
Aliment. Pharmacol. Ther
, vol.24
, pp. 715-729
-
-
Derijks, L.J.1
Gilissen, L.P.2
Hooymans, P.M.3
Hommes, D.W.4
-
9
-
-
0033376417
-
Thiopurine methyltransferase genotype and the toxicity of azathioprine in Japanese
-
Ishioka, S., Hiyama, K., Sato, H., Yamanishi, Y., McLeod, H. L., Kumagai, K., Maeda, H. and Yamakido, M.: Thiopurine methyltransferase genotype and the toxicity of azathioprine in Japanese. Intern. Med., 38: 944-947 (1999).
-
(1999)
Intern. Med
, vol.38
, pp. 944-947
-
-
Ishioka, S.1
Hiyama, K.2
Sato, H.3
Yamanishi, Y.4
McLeod, H.L.5
Kumagai, K.6
Maeda, H.7
Yamakido, M.8
-
10
-
-
0033486029
-
Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locus
-
Relling, M. V., Hancock, M. L., Rivera, G. K., Sandlund, J. T., Ribeiro, R. C., Krynetski, E. Y., Pui, C. H. and Evans, W. E.: Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locus. J. Natl. Cancer Inst., 91: 2001-2008 (1999).
-
(1999)
J. Natl. Cancer Inst
, vol.91
, pp. 2001-2008
-
-
Relling, M.V.1
Hancock, M.L.2
Rivera, G.K.3
Sandlund, J.T.4
Ribeiro, R.C.5
Krynetski, E.Y.6
Pui, C.H.7
Evans, W.E.8
-
11
-
-
0036820724
-
Genetic basis of inosine triphosphate pyrophosphohydrolase deficiency
-
Sumi, S., Marinaki, A. M., Arenas, M., Fairbanks, L., Shobowale-Bakre, M., Rees, D. C., Thein, S. L., Ansari, A., Sanderson, J., De Abreu, R. A., Simmonds, H. A. and Duley, J. A.: Genetic basis of inosine triphosphate pyrophosphohydrolase deficiency. Hum. Genet., 111: 36-367 (2002).
-
(2002)
Hum. Genet
, vol.111
, pp. 36-367
-
-
Sumi, S.1
Marinaki, A.M.2
Arenas, M.3
Fairbanks, L.4
Shobowale-Bakre, M.5
Rees, D.C.6
Thein, S.L.7
Ansari, A.8
Sanderson, J.9
de Abreu, R.A.10
Simmonds, H.A.11
Duley, J.A.12
-
12
-
-
12144285961
-
Adverse drug reactions to azathioprine therapy are associated with polymorphism in the gene encoding inosine triphosphate pyrophosphatase (ITPase)
-
Marinaki, A. M., Ansari, A., Duley, J. A., Arenas, M., Sumi, S., Lewis, C. M., Shobowale-Bakreel, M., Escuredo, E., Fairbanks, L. D. and Sanderson, J. D.: Adverse drug reactions to azathioprine therapy are associated with polymorphism in the gene encoding inosine triphosphate pyrophosphatase (ITPase). Pharmacogenetics, 14: 181-187 (2004).
-
(2004)
Pharmacogenetics
, vol.14
, pp. 181-187
-
-
Marinaki, A.M.1
Ansari, A.2
Duley, J.A.3
Arenas, M.4
Sumi, S.5
Lewis, C.M.6
Shobowale-Bakreel, M.7
Escuredo, E.8
Fairbanks, L.D.9
Sanderson, J.D.10
-
13
-
-
34247094129
-
Three novel single nucleotide polymorphisms of the human thiopurine S-methyltransferase gene in Japanese individuals
-
Sasaki, T., Goto, E., Konno, Y., Hiratsuka, M. and Mizugaki, M.: Three novel single nucleotide polymorphisms of the human thiopurine S-methyltransferase gene in Japanese individuals. Drug Metab. Pharmacokinet., 21: 332-336 (2006).
-
(2006)
Drug Metab. Pharmacokinet
, vol.21
, pp. 332-336
-
-
Sasaki, T.1
Goto, E.2
Konno, Y.3
Hiratsuka, M.4
Mizugaki, M.5
-
14
-
-
40049090510
-
Functional characterization of human xanthine oxidase allelic variants
-
Kudo, M., Moteki, T., Sasaki, T., Konno, Y., Ujiie, S., Onose, A., Mizugaki, M., Ishikawa, M. and Hiratsuka, M.: Functional characterization of human xanthine oxidase allelic variants. Pharmacogenet. Genomics, 18: 243-251 (2008).
-
(2008)
Pharmacogenet. Genomics
, vol.18
, pp. 243-251
-
-
Kudo, M.1
Moteki, T.2
Sasaki, T.3
Konno, Y.4
Ujiie, S.5
Onose, A.6
Mizugaki, M.7
Ishikawa, M.8
Hiratsuka, M.9
-
15
-
-
37249032702
-
IMPDH activity in thiopurine-treated patients with inflammatory bowel disease - relation to TPMT activity and metabolite concentrations
-
Haglund, S., Taipalensuu, J., Peterson, C. and Almer, S.: IMPDH activity in thiopurine-treated patients with inflammatory bowel disease - relation to TPMT activity and metabolite concentrations. Br. J. Clin. Pharmacol., 65: 69-77 (2008).
-
(2008)
Br. J. Clin. Pharmacol
, vol.65
, pp. 69-77
-
-
Haglund, S.1
Taipalensuu, J.2
Peterson, C.3
Almer, S.4
-
16
-
-
0027717956
-
Characterization of human type I and type II IMP dehydrogenases
-
Carr, S. F., Papp, E., Wu, J. C. and Natsumeda, Y.: Characterization of human type I and type II IMP dehydrogenases. J. Biol. Chem., 268: 27286-27290 (1993).
-
(1993)
J. Biol. Chem
, vol.268
, pp. 27286-27290
-
-
Carr, S.F.1
Papp, E.2
Wu, J.C.3
Natsumeda, Y.4
-
17
-
-
0025961794
-
Expression of human IMP dehydrogenase types I and II in Escherichia coli and distribution in human normal lymphocytes and leukemic cell lines
-
Konno, Y., Natsumeda, Y., Nagai, M., Yamaji, Y., Ohno, S., Suzuki, K. and Weber, G.: Expression of human IMP dehydrogenase types I and II in Escherichia coli and distribution in human normal lymphocytes and leukemic cell lines. J. Biol. Chem., 266: 506-509 (1991).
-
(1991)
J. Biol. Chem
, vol.266
, pp. 506-509
-
-
Konno, Y.1
Natsumeda, Y.2
Nagai, M.3
Yamaji, Y.4
Ohno, S.5
Suzuki, K.6
Weber, G.7
-
18
-
-
0026378294
-
Selective up-regulation of type II inosine 5′-monophosphate dehydrogenase messenger RNA expression in human leukemias
-
Nagai, M., Natsumeda, Y., Konno, Y., Hoffman, R., Irino, S. and Weber, G.: Selective up-regulation of type II inosine 5′-monophosphate dehydrogenase messenger RNA expression in human leukemias. Cancer Res., 51: 3886-3890 (1991).
-
(1991)
Cancer Res
, vol.51
, pp. 3886-3890
-
-
Nagai, M.1
Natsumeda, Y.2
Konno, Y.3
Hoffman, R.4
Irino, S.5
Weber, G.6
-
19
-
-
0026546968
-
Proliferation-linked regulation of type II IMP dehydrogenase gene in human normal lymphocytes and HL-60 leukemic cells
-
Nagai, M., Natsumeda, Y. and Weber, G.: Proliferation-linked regulation of type II IMP dehydrogenase gene in human normal lymphocytes and HL-60 leukemic cells. Cancer Res., 52: 258-261 (1992).
-
(1992)
Cancer Res
, vol.52
, pp. 258-261
-
-
Nagai, M.1
Natsumeda, Y.2
Weber, G.3
-
20
-
-
0033616611
-
Crystal structure of human type II inosine monophosphate dehydrogenase: Implications for ligand binding and drug design
-
Colby, T. D., Vanderveen, K., Strickler, M. D., Markham, G. D. and Goldstein, B. M.: Crystal structure of human type II inosine monophosphate dehydrogenase: implications for ligand binding and drug design. Proc. Natl. Acad. Sci. USA, 96: 3531-3536 (1999).
-
(1999)
Proc. Natl. Acad. Sci. Usa
, vol.96
, pp. 3531-3536
-
-
Colby, T.D.1
Vanderveen, K.2
Strickler, M.D.3
Markham, G.D.4
Goldstein, B.M.5
-
21
-
-
0033230591
-
Biochemical analysis of the modular enzyme inosine 5′- monophosphate dehydrogenase
-
Nimmesgern, E., Black, J., Futer, O., Fulghum, J. R., Chambers, S. P., Brummel, C. L., Raybuck, S. A. and Sintchak, M. D.: Biochemical analysis of the modular enzyme inosine 5′- monophosphate dehydrogenase. Protein Expr. Purif., 17: 282-289 (1999).
-
(1999)
Protein Expr. Purif
, vol.17
, pp. 282-289
-
-
Nimmesgern, E.1
Black, J.2
Futer, O.3
Fulghum, J.R.4
Chambers, S.P.5
Brummel, C.L.6
Raybuck, S.A.7
Sintchak, M.D.8
-
23
-
-
0035379753
-
Cloning, expression, and characterization of a human inosine triphosphate pyrophosphatase encoded by the itpa gene
-
Lin, S., McLennan, A. G., Ying, K., Wang, Z., Gu, S., Jin, H., Wu, C., Liu, W., Yuan, Y., Tang, R., Xie, Y. and Mao, Y.: Cloning, expression, and characterization of a human inosine triphosphate pyrophosphatase encoded by the itpa gene. J. Biol. Chem., 276: 18695-18701 (2001).
-
(2001)
J. Biol. Chem
, vol.276
, pp. 18695-18701
-
-
Lin, S.1
McLennan, A.G.2
Ying, K.3
Wang, Z.4
Gu, S.5
Jin, H.6
Wu, C.7
Liu, W.8
Yuan, Y.9
Tang, R.10
Xie, Y.11
Mao, Y.12
|