A Cre/LoxP conditional luciferase reporter transgenic mouse for bioluminescence monitoring of tumorigenesis

Genesis

Volumn 47, Issue 10, 2009, Pages 659-666

  Woolfenden, Steve ^a   Zhu, Haihao ^a   Charest, Al ^a,b  

^a TUFTS MEDICAL CENTER   (United States)

^b TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

FIG ROS; Glioblastoma; In vivo imaging; Tumor progression; Tyrosine kinase

Indexed keywords

CRE RECOMBINASE; LUCIFERASE; ONCOPROTEIN; PROTEIN LOXP; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOLUMINESCENCE; CARCINOGENESIS; CONTROLLED STUDY; ENZYME ACTIVITY; EPIGENETICS; FEMALE; GENE CASSETTE; GENE EXPRESSION; GENETIC RECOMBINATION; GENETIC STRAIN; GLIOBLASTOMA; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; TRANSGENE; TUMOR GROWTH; TUMOR VOLUME;

ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; FEMALE; GENES, REPORTER; GLIOBLASTOMA; INTEGRASES; LUCIFERASES; LUMINESCENT MEASUREMENTS; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, TRANSGENIC;

MUS MUSCULUS;

EID: 73249149881     PISSN: 1526954X     EISSN: 1526968X     Source Type: Journal    
DOI: 10.1002/dvg.20545     Document Type: Article

References (13)

1. Ausubel F, Brent R, Kingston RE, Moore DD, Seidman JG, Smith JA, Struhl K, editors. 2001. Current protocols in molecular biology. New York: Wiley.
2. Charest A, Wilker EW, McLaughlin ME, Lane K, Gowda R, Coven S, McMahon K, Kovach S, Feng Y, Yaffe MB, Jacks T, Housman D. 2006. ROS fusion tyrosine kinase activates a SH2 domain-containing phosphatase-2/phosphatidylinositol 3-kinase/mammalian target of rapamycin signaling axis to form glioblastoma in mice. Cancer Res 66:7473-7481.
3. Contag CH, Bachmann MH. 2002. Advances in in vivo bioluminescence imaging of gene expression. Annu Rev Biomed Eng 4:235-260.
4. Hennet T, Hagen FK, Tabak LA, Marth JD. 1995. T-cell-specific deletion of a polypeptide N-acetylgalactosaminyl-transferase gene by site-directed recombination. Proc Natl Acad Sci USA 92: 12070-12074.
5. Jackson EL, Willis N, Mercer K, Bronson RT, Crowley D, Montoya R, Jacks T, Tuveson DA. 2001. Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras. Genes Dev 15:3243-3248.
6. Kang JH, Chung JK. 2008. Molecular-genetic imaging based on reporter gene expression. J Nucl Med 49 (Suppl 2):164S-179S.
7. Lesche R, Groszer M, Gao J, Wang Y, Messing A, Sun H, Liu X, Wu H. 2002. Cre/loxP-mediated inactivation of the murine Pten tumor suppressor gene. Genesis 32:148-149.
8. Liao CP, Zhong C, Saribekyan G, Bading J, Park R, Conti PS, Moats R, Berns A, Shi W, Zhou Z, Nikitin AY, Roy-Burman P. 2007. Mouse models of prostate adenocarcinoma with the capacity to monitor spontaneous carcinogenesis by bioluminescence or fluorescence. Cancer Res 67:7525-7533. Lyons SK, Meuwissen R, Krimpenfort P, Berns A. 2003. The generation of a conditional reporter that enables bioluminescence imaging of Cre/ loxP-dependent tumorigenesis in mice. Cancer Res 63:7042-7046.
9. Miyazaki J, Takaki S, Araki K, Tashiro F, Tominaga A, Takatsu K, Yamamura K. 1989. Expression vector system based on the chicken beta-actin promoter directs efficient production of interleukin-5. Gene 79:269-277.
10. Rousseaux S, Reynoird N, Escoffier E, Thevenon J, Caron C, Khochbin S. 2008. Epigenetic reprogramming of the male genome during gametogenesis and in the zygote. Reprod Biomed Online 16:492-503.
11. Safran M, Kim WY, Kung AL, Horner JW, DePinho RA, Kaelin WG Jr. 2003. Mouse reporter strain for noninvasive bioluminescent imaging of cells that have undergone Cre-mediated recombination. Mol Imaging 2:297-302.
12. Serrano M, Lee H, Chin L, Cordon-Cardo C, Beach D, DePinho RA. 1996. Role of the INK4a locus in tumor suppression and cell mortality. Cell 85:27-37.
13. Svensson RU, Shey MR, Ballas ZK, Dorkin JR, Goldberg M, Akinc A, Langer R, Anderson DG, Bumcrot D, Henry MD. 2008. Assessing siRNA pharmacodynamics in a luciferase-expressing mouse. Mol Ther 16:1995-2001.