Association of polymorphism in the receptor for advanced glycation end products (RAGE) gene with circulating RAGE levels

Journal of Clinical Endocrinology and Metabolism

Volumn 94, Issue 12, 2009, Pages 5174-5180

  Gaens, Katrien H J ^a,b   Ferreira, Isabel ^a,b   Van Der Kallen, Carla J H ^a,b   Van Greevenbroek, Marleen M J ^a,b   Blaak, Ellen E ^a,c   Feskens, Edith J M ^d   Dekker, Jacqueline M ^e   Nijpels, Giel ^e   Heine, Robert J ^e   'T Hart, Leen M ^f   De Groot, Philip G ^g   Stehouwer, Coen D A ^a,b   Schalkwijk, Casper G ^a,b  

^a MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^b MAASTRICHT UNIVERSITY   (Netherlands)

^c MAASTRICHT UNIVERSITY   (Netherlands)

^d WAGENINGEN UNIVERSITY   (Netherlands)

^e VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^f LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^g UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID;

ADULT; ARTICLE; COHORT ANALYSIS; COMPARATIVE STUDY; DEMOGRAPHY; DISEASE ASSOCIATION; FEMALE; GENE IDENTIFICATION; GENE INTERACTION; GENETIC VARIABILITY; GENOTYPE; GLUCOSE METABOLISM; GLYCATION; HUMAN; IMMUNOBLOTTING; IMMUNOGLOBULIN GENE; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; RECEPTOR FOR ADVANCED GLYCATION END PRODUCT GENE; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 73249144472     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2009-1067     Document Type: Article

References (27)

1. Bierhaus A, Humpert PM, Morcos M, Wendt T, Chavakis T, Arnold B, Stern DM, Nawroth PP 2005 Understanding RAGE, the receptor for advanced glycation end products. J Mol Med 83:876-886
2. Yamagishi S, Nakamura K, Imaizumi T 2005 Advanced glycation end products (AGEs) and diabetic vascular complications. Curr Diabetes Rev 1:93-106
3. Basta G 2008 Receptor for advanced glycation endproducts and atherosclerosis: From basic mechanisms to clinical implications. Atherosclerosis 196:9-21
4. Yonekura H, Yamamoto Y, Sakurai S, Petrova RG, Abedin MJ, Li H, Yasui K, Takeuchi M, Makita Z, Takasawa S, Okamoto H, Watanabe T, Yamamoto H 2003 Novel splice variants of the receptor for advanced glycation end-products expressed in human vascular endothelial cells and pericytes, and their putative roles in diabetes-induced vascular injury. Biochem J 370:1097-1109
5. Hudson BI, Carter AM, Harja E, Kalea AZ, Arriero M, Yang H, Grant PJ, Schmidt AM 2008 Identification, classification, and expression of RAGE gene splice variants. FASEB J 22:1572-1580
6. Raucci A, Cugusi S, Antonelli A, Barabino SM, Monti L, Bierhaus A, Reiss K, Saftig P, Bianchi ME 2008 A soluble form of the receptor for advanced glycation endproducts (RAGE) is produced by proteolytic cleavage of the membrane-bound form by the sheddase a disintegrin and metalloprotease 10 (ADAM10). FASEB J 22:3716-3727
7. Zhang L, Bukulin M, Kojro E, Roth A, Metz VV, Fahrenholz F, Nawroth PP, Bierhaus A, Postina R 2008 Receptor for advanced glycation end products is subjected to protein ectodomain shedding by metalloproteinases. J Biol Chem 283:35507-35516
8. Nakamura K, Yamagishi S, Adachi H, Kurita-Nakamura Y, Matsui T, Yoshida T, Sato A, Imaizumi T 2007 Elevation of soluble form of receptor for advanced glycation end products (sRAGE) in diabetic subjects with coronary artery disease. Diabetes Metab Res Rev 23:368-371
9. Nin JW, Ferreira I, Schalkwijk CG, Prins MH, Chaturvedi N, Fuller JH, Stehouwer CD 2009 Levels of soluble receptor for AGE are cross-sectionally associated with cardiovascular disease in type 1 diabetes, and this association is partially mediated by endothelial and renal dysfunction and by low-grade inflammation: the EURODIAB Prospective Complications Study. Diabetologia 52:705-714
10. Hofmann MA, Drury S, Hudson BI, Gleason MR, Qu W, Lu Y, Lalla E, Chitnis S, Monteiro J, Stickland MH, Bucciarelli LG, Moser B, Moxley G, Itescu S, Grant PJ, Gregersen PK, Stern DM, Schmidt AM 2002 RAGE and arthritis: the G82S polymorphism amplifies the inflammatory response. Genes Immun 3:123-135
11. Osawa M, Yamamoto Y, Munesue S, Murakami N, Sakurai S, Watanabe T, Yonekura H, Uchigata Y, Iwamoto Y, Yamamoto H 2007 De-N-glycosylation or G82S mutation of RAGE sensitizes its interaction with advanced glycation endproducts. Biochim Biophys Acta 1770:1468-1474
12. Hudson BI, Stickland MH, Futers TS, Grant PJ 2001 Effects of novel polymorphisms in the RAGE gene on transcriptional regulation and their association with diabetic retinopathy. Diabetes 50:1505-1511
13. Jang Y, Kim JY, Kang SM, Kim JS, Chae JS, Kim OY, Koh SJ, Lee HC, Ahn CW, Song YD, Lee JH 2007 Association of the Gly82Ser polymorphism in the receptor for advanced glycation end products (RAGE) gene with circulating levels of soluble RAGE and inflammatory markers in nondiabetic and nonobese Koreans. Metabolism 56:199-205
14. Kim OY, Jo SH, Jang Y, Chae JS, Kim JY, Hyun YJ, Lee JH 2009 G allele at RAGE SNP82 is associated with proinflammatory markers in obese subjects. Nutr Res 29:106-113
15. Jacobs M, van Greevenbroek MM, van Der Kallen CJ, Ferreira I, Blaak EE, Feskens EJ 2009 Role of inflammation in the association between the metabolic syndrome and cardiovascular diseases. Eur J Clin Invest 39:437-444
16. Gaens KH, van Der Kallen CJ, van Greevenbroek MM, Feskens EJ, Stehouwer CD, Schalkwijk CG 2008 Receptor for advanced glycation end product polymorphisms and type 2 diabetes: the CODAM study. Ann NY Acad Sci 1126:162-165
17. Teerlink T, Barto R, Ten Brink HJ, Schalkwijk CG 2004 Measurement of Nε-(carboxymethyl)lysine and Nε-(carboxyethyl)lysine in human plasma protein by stable-isotope-dilution tandem mass spectrometry. Clin Chem 50:1222-1228
18. Engelen L, Ferreira I, Brouwers O, Henry RM, Dekker JM, Nijpels G, Heine RJ, van Greevenbroek MM, van der Kallen CJ, Blaak EE, Feskens EJ, ten Cate H, Stehouwer CD, Schalkwijk CG 2009 Polymorphisms in glyoxalase 1 gene are not associated with vascular complications: the Hoorn and CoDAM studies. J Hypertens 27:1399-1403
19. Hudson BI, Stickland MH, Grant PJ 1998 Identification of polymorphisms in the receptor for advanced glycation end products (RAGE) gene: prevalence in type 2 diabetes and ethnic groups. Diabetes 47:1155-1157
20. Catalano M, Cortelazzo A, Santi R, Contino L, Demicheli M, Yilmaz Y, Zorzetto M, Campo I, Lanati N, Emanuele E 2008 The Pro12Ala polymorphism of peroxisome proliferator-activated receptor-γ2 gene is associated with plasma levels of soluble RAGE (receptor for advanced glycation endproducts) and the presence of peripheral arterial disease. Clin Biochem 41:981-985
21. Hofmann MA, Yang Q, Harja E, Kedia P, Gregersen PK, Cupples LA, Schmidt AM, Hudson BI 2005 The RAGE Gly82Ser polymorphism is not associated with cardiovascular disease in the Framingham offspring study. Atherosclerosis 182:301-305
22. Poirier O, Nicaud V, Vionnet N, Raoux S, Tarnow L, Vlassara H, Parving HH, Cambien F 2001 Polymorphism screening of four genes encoding advanced glycation end-product putative receptors. Association study with nephropathy in type 1 diabetic patients. Diabetes 50:1214-1218
23. Yoshioka K, Yoshida T, Takakura Y, Umekawa T, Kogure A, Toda H, Yoshikawa T 2005 Relation between polymorphisms G1704T and G82S of rage gene and diabetic retinopathy in Japanese type 2 diabetic patients. Intern Med 44:417-421
24. Yoon SJ, Park S, Shim CY, Park CM, Ko YG, Choi D, Park HY, Oh B, Kim H, Jang Y, Chung N 2007 Association of RAGE gene polymorphisms with coronary artery disease in the Korean population. Coron Artery Dis 18:1-8
25. Kumaramanickavel G, Ramprasad VL, Sripriya S, Upadyay NK, Paul PG, Sharma T 2002 Association of Gly82Ser polymorphism in the RAGE gene with diabetic retinopathy in type II diabetic Asian Indian patients. J Diabetes Complications 16:391-394
26. Nakamura K, Yamagishi S, Adachi H, Matsui T, Kurita-Nakamura Y, Takeuchi M, Inoue H, Imaizumi T 2008 Serum levels of soluble form of receptor for advanced glycation end products (sRAGE) are positively associated with circulating AGEs and soluble form of VCAM-1 in patients with type 2 diabetes. Microvasc Res 76:52-56
27. Yamagishi S, Adachi H, Nakamura K, Matsui T, Jinnouchi Y, Takenaka K, Takeuchi M, Enomoto M, Furuki K, Hino A, Shigeto Y, Imaizumi T 2006 Positive association between serum levels of advanced glycation end products and the soluble form of receptor for advanced glycation end products in nondiabetic subjects. Metabolism 55:1227-1231