Hepatic steatosis, body mass index and long term outcome in patients undergoing hepatectomy for colorectal liver metastases

European Journal of Surgical Oncology

Volumn 36, Issue 1, 2010, Pages 52-57

  Pathak, S ^a   Tang, J M F ^b   Terlizzo, M ^a   Poston, G J ^a   Malik, Hassan Z ^c  

^a UNIVERSITY HOSPITAL AINTREE   (United Kingdom)

^b UNIVERSITY OF LIVERPOOL   (United Kingdom)

^c ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST   (United Kingdom)

Author keywords

Body mass index; Hepatic steatosis; Neoadjuvant chemotherapy; Post operative outcome

Indexed keywords

FLUOROURACIL; FOLINIC ACID; IRINOTECAN; OXALIPLATIN;

ADULT; AGED; ARTICLE; BODY MASS; CANCER ADJUVANT THERAPY; CANCER COMBINATION CHEMOTHERAPY; CANCER PATIENT; CANCER SURVIVAL; COHORT ANALYSIS; COLORECTAL CANCER; DIABETES MELLITUS; DISEASE SEVERITY; FATTY LIVER; FEMALE; FOLLOW UP; HIGH RISK PATIENT; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LIVER CIRRHOSIS; LIVER METASTASIS; LIVER RESECTION; MAJOR CLINICAL STUDY; MALE; OBESITY; PRIORITY JOURNAL; RETROSPECTIVE STUDY; RISK FACTOR; SURVIVAL TIME; TREATMENT OUTCOME;

AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BODY MASS INDEX; COLORECTAL NEOPLASMS; DIABETES COMPLICATIONS; FATTY LIVER; FEMALE; HEPATECTOMY; HUMANS; LIVER NEOPLASMS; MALE; MIDDLE AGED; NEOADJUVANT THERAPY; PROGNOSIS; RISK FACTORS; SURVIVAL RATE;

EID: 73249136662     PISSN: 07487983     EISSN: 15322157     Source Type: Journal    
DOI: 10.1016/j.ejso.2009.09.004     Document Type: Article

References (16)

1. Chiappini F., Barrier A., Saffroy R., et al. Exploration of global gene expression in human liver steatosis by high-density oligonucleotide microarray. Lab Invest 86 2 (2006) 154-165
2. Browning J.D., Szczepaniak L., Dobbins R., et al. Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology 40 (2004) 1387-1395
3. Ong J.P., Elariny H., Collantes R., et al. Predictors of non-alcoholic steatohepatitis and advanced fibrosis in morbidly obese patients. Obes Surg 15 (2005) 310-315
4. Angulo P. Obesity and nonalcoholic fatty liver disease. Nutr Rev 65 6 (2007) S57-S63
5. Cotran R.S., Kumar V., and Collins T. Robbins pathologic basis of disease. 6th ed. (1999), Saunders, Philadelphia pp. 39-40
6. McCullough J.A. Pathophysiology of nonalcoholic steatohepatitis. J Clin Gastroenterol 40 1 (2006) S17-S29
7. Yan E., Durazo F., Tong M., and Hong K. Nonalcoholic fatty liver disease: pathogenesis, identification, progression, and management. Nutr Rev 65 8 (2007) 376-384
8. Day C.O., and James O.F. Steatohepatitis: a tale of two "hits"?. Gastroenterologist 114 (1998) 842-845
9. Vauthey J.N., Pawlik T.M., Ribero D., et al. Chemotherapy regimen predicts steatohepatitis and an increase in 90-day mortality after surgery for hepatic colorectal metastases. J Clin Oncol 24 13 (2006) 2065-2072
10. Vetelainen R., van Vliet A., Gouma D.J., and Gulik T.M. Steatosis as a risk factor in liver surgery. Ann Surg 245 (2007) 20-30
11. McCormack L., Petrowsky H., Jochum W., Furrer K., and Clavien P.A. Hepatic steatosis is a risk factor for postoperative complications after major hepatectomy. Ann Surg 245 (2007) 923-930
12. Gomez D, Malik HZ, Bonny GK, et al. Steatosis predicts postoperative morbidity following hepatic resection.
13. McCormack L., Capitanich P., Quiñonez E., et al. Liver surgery in presence of cirrhosis or steatosis: is morbidity increased?. Patient Saf Surg 2 (2008) 8
14. Mullen J.T., Davenport D.L., and Hutter M.M. Impact of body mass index on perioperative outcomes in patients undergoing major intra-abdominal cancer surgery. Ann Surg Oncol 15 8 (2008) 2164-2172 [Epub 2008 June 12]
15. Zhang B.H., Weltman M., and Farrell G.C. Does steatohepatitis impair liver regeneration? A study in a dietary model of non-alcoholic steatohepatitis in rats. J Gastroenterol Hepatol 14 2 (1999) 133-137
16. Kooby D.A., Fong Y., Suriawinata A., et al. Impact of steatosis on peri-operative outcome following hepatic resection. J Gastrointest Surg 7 8 (2003) 1034-1044