Synthesis of deuterium labelled diclofenac with improved isotopic enrichment

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 52, Issue 13, 2009, Pages 535-537

  Keying, Wu ^a   Lei, Tian ^a   Hongye, Li ^a   Jian, Li ^a   Liqin, Chen ^b  

^a NANJING UNIVERSITY OF AERONAUTICS AND ASTRONAUTICS   (China)

^b NANJING TECH UNIVERSITY   (China)

Author keywords

Deuterium label; Diclofenac; Improved isotopic enrichment

Indexed keywords

ALTERNATIVE ROUTES; DEUTERIUM LABEL; DICLOFENAC; HUMAN METABOLITES; IMPROVED ISOTOPIC ENRICHMENT; ISOTOPIC ENRICHMENT;

DEUTERIUM;

2 (2 (2,6 DICHLOROPHENYLAMINO)PHENYL[2H4]) N,N DIMETHYLACETAMIDE; 2 (2 (2,6 DICHLOROPHENYLAMINO)PHENYL[2H4])ACETIC ACID; 2 (2 IODOPHENYL[2H4]) N,N DIMETHYLACETAMIDE; 2 (2 IODOPHENYL[2H4])ACETIC ACID; 2 PHENYL[2H5] ACETIC ACID; 4' HYDROXYDICLOFENAC; ACETIC ACID DERIVATIVE; DEUTERIUM; DICLOFENAC DERIVATIVE; DRUG METABOLITE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; DRUG SYNTHESIS; ISOTOPE LABELING; MASS SPECTROMETRY; PROTON NUCLEAR MAGNETIC RESONANCE;

EID: 73249115965     PISSN: 03624803     EISSN: 10991344     Source Type: Journal    
DOI: 10.1002/jlcr.1669     Document Type: Article

References (7)

1. A. R. Sallmann, Am. J. Med. 1986, 80, 29.
2. D. Leroy, J. Richard, J. Godbillin, J. Label. Compd. Radiopharm. 1993, 33, 1019-1027.
3. I. Waterhouse, J. Label. Compd. Radiopharm. 1999, 42, 1075-1083.
4. F. Balssa, Y . Bonnaire, J. Label. Compd. Radiopharm. 2007, 50, 207-210.
5. P. Moser, A. Sallmann, I. Wiesenberg, J. Med. Chem. 1990, 33, 2358.
6. V. B. Oza, C. Smith, P. Raman, E. K. Koepf, H. A. Lashuel, H. M. Petrassi, K. P. Chiang, E. T. Powers, J. Sachettini, J. W. Kelly, J. Med. Chem. 2002, 45, 321-332.
7. A. I. Vogel, Practical Organic Chemistry, 3rd edition, Longmans, London, 1956, pp. 426.