Synthesis of deuterium-labelled meloxicam and piroxicam

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 50, Issue 3, 2007, Pages 207-210

  Balssa, Frédéric ^a   Bonnaire, Yves ^a  

^a Laboratoire des Courses Hippiques   (France)

Author keywords

Deuterium; Labelled; Meloxicam; Piroxicam; Synthesis

Indexed keywords

LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PYRIDINE; SUGAR SUBSTITUTES;

FORENSIC LABORATORY; FOUR-STEP SYNTHESIS; ISOTOPE DILUTION MASS SPECTROMETRY; LABELED; MELOXICAM; OXICAMS; PIROXICAM;

DEUTERIUM;

2 METHYL 4 HYDROXY 2H 1,2 BENZOTHIAZINE 3 CARBOXYLIC ACID METHYLESTER 1,1 DIOXIDE D3; 3 OXO 1,2 BENZOISOTHIAZOLINE 2 ACETIC ACID METHYLESTER 1,1 DIOXIDE; 4 HYDROXY 2H 1,2 BENZOTHIAZINE 3 CARBOXYLIC ACID METHYLESTER 1,1 DIOXIDE; ISOXICAM; MELOXICAM D3; NONSTEROID ANTIINFLAMMATORY AGENT; PIROXICAM D3; SACCHARIN; SUDOXICAM; TENOXICAM; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; ISOTOPE DILUTION ASSAY; ISOTOPE LABELING; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS;

EID: 34248532740     PISSN: 03624803     EISSN: 10991344     Source Type: Journal    
DOI: 10.1002/jlcr.1261     Document Type: Article

References (14)

1. Hobbs DC, Twomey TM. Drug Metab Dispos 1977; 5: 75-81.
2. Hobbs DC, Twomey TM. Drug Metab Dispos 1981; 9: 114-118.
3. Woolf TF, Black A, Sedman A, Chang T. Eur J Drug Metab Pharmacokinet 1992; 17: 21-27.
4. Borondy PE, Michniewicz BM. Drug Metab Dispos 1984; 12: 444-451.
5. Woolf TF, Black A, Hicks JL, Lee H, Huang CC, Chang T. Drug Metab Dispos 1989; 17: 662-668.
6. Borondy PE, Michniewicz BM, Eiseman I, Yakatan GJ. Pharmacologist 1981; 23: 212.
7. Borondy PE, Michniewicz BM, Yakatan GJ. Pharmacologist 1982; 24: 95.
8. Busch U, Engelhardt G. Drugs Exp Clin Res 1990; 16: 49-52.
9. Schmid J, Busch U, Trummlitz G, Prox A, Kaschke S, Wachsmuth H. Xenobiotica 1995; 25: 1219-1236.
10. Schmid J, Busch U, Heinzel G, Bozler G, Kaschke S, Kummer M. Drug Metab Dispos 1995; 23: 1206-1213.
11. Busch U, Schmid J, Heinzel G, Schmaus H, Baierl J, Huber C, Roth W. Drug Metab Dispos 1998; 26: 576-584.
12. Ichihara S, Tsuyuki Y, Tomisawa H, Fukazawa H, Nakayama N, Tateishi M, Joly R. Xenobiotica 1984; 14: 727-739.
13. Lombardino JG, Wiseman EH, McLamore WM. J Med Chem 1971; 14: 1171-1175.
14. Zinnes H, Lindo NA, Sircar JC, Schwartz ML, Shavel Jr J, DiPasquale G. J Med Chem 1973; 16: 44-48.