Multicentric, controlled clinical study to evaluate effectiveness and safety of miltefosine and allopurinol for canine leishmaniosis

Veterinary Dermatology

Volumn 20, Issue 5-6, 2009, Pages 397-404

  Miró, Guadalupe ^a   Oliva, Gaetano ^b   Cruz, Israel ^c   Cañavate, Carmen ^c   Mortarino, Michele ^d   Vischer, Claudia ^e   Bianciardi, Paolo ^f  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c INSTITUTO DE SALUD CARLOS III   (Spain)

^d UNIVERSITY OF MILAN   (Italy)

^e Virbac SA   (France)

^f NONE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOPURINOL; DRUG DERIVATIVE; MEGLUMINE; MEGLUMINE ANTIMONIATE; MILTEFOSINE; ORGANOMETALLIC COMPOUND; PHOSPHORYLCHOLINE;

ANIMAL; ANIMAL DISEASE; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOG; DOG DISEASE; DRUG COMBINATION; FEMALE; MALE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL; SKIN LEISHMANIASIS;

ALLOPURINOL; ANIMALS; DOG DISEASES; DOGS; DRUG THERAPY, COMBINATION; FEMALE; LEISHMANIASIS, CUTANEOUS; MALE; MEGLUMINE; ORGANOMETALLIC COMPOUNDS; PHOSPHORYLCHOLINE;

CANIS FAMILIARIS;

EID: 73149123771     PISSN: 09594493     EISSN: 13653164     Source Type: Journal    
DOI: 10.1111/j.1365-3164.2009.00824.x     Document Type: Article

References (31)

1. Mettler M, Grimm F, Naucke TJ et al. Canine leishmaniosis in Central Europe: retrospective survey and serological study of imported and travelling dogs. Berliner und Münchener Tierärztliche Wochenschrift 2005 118 : 37 44.
2. Dujardin JC, Campino L, Cañavate C et al. Spread of vector-borne diseases and neglect of leishmaniasis, Europe. Emerging Infectious Diseases 2008 14 : 1013 1017.
3. Alvar J, Cañavate C, Molina R et al. Canine leishmaniasis. Advances in Parasitology 2004 57 : 1 88.
4. Noli C, Auxilia ST. Treatment of canine Old World visceral leishmaniasis: a systematic review. Veterinary Dermatology 2005 16 : 213 232.
5. ®) of Leishmania infantum isolated from dogs after several courses of drug treatment. Annals of Tropical Medicine and Parasitology 1992 86 : 613 620.
6. Berman JD. Chemotherapy for leishmaniasis: biochemical mechanisms, clinical efficacy and future strategies. Reviews of Infectious Diseases 1988 10 : 560 586.
7. Koutinas AF, Saridomichelakis MN, Mylonakis ME. A randomised, blinded, placebo-controlled clinical trial with allopurinol in canine leishmaniosis. Veterinary Parasitology 2001 98 : 247 261.
8. Denerolle P, Bourdoiseau G. Combination allopurinol and antimony treatment versus antimony alone in the treatment of canine leishmaniasis (96 cases). Journal of Veterinary Internal Medicine 1999 13 : 413 415.
9. Baneth G, Shaw SE. Chemotherapy of canine leishmaniosis. Veterinary Parasitology 2002 106 : 315 324.
10. Ginel PJ, Lucena R, Lopez R et al. Use of allopurinol for maintenance of remission in dogs with leishmaniasis. Journal of Small Animal Practice 1998 39 : 271 274.
11. Croft SL, Neal RA, Pendergast W et al. The activity of alkyl phosphorylcholines and related derivatives against Leishmania donovani. Biochemical Pharmacology 1987 36 : 2633 2636.
12. Croft SL, Neal RA, Thornton EA et al. Antileishmanial activity of the ether phospholipids ilmofosine. Transactions of the Royal Society of Tropical Medicine and Hygiene 1993 87 : 217 219.
13. Croft SL, Snowdon D, Yarley V. The activities of four anticancer alkylphospholipids against Leishmania donovani, Trypanosoma cruzi and Trypanosoma brucei. Journal of Antimicrobial Chemotherapy 1996 38 : 1041 1047. (Pubitemid 27073283)
14. Escobar P, Matu S, Marques C et al. Sensitivities of Leishmania species to hexadecylphosphocholine (miltefosine), ET-18-OCH3 (eldelfosine) and amphotericin B. Acta Tropica 2002 81 : 151 157.
15. Kuhlencord A, Maniera T, Eibl H et al. Hexadecylphosphocholine: oral treatment of visceral leishmaniasis in mice. Antimicrobial Agents and Chemotherapy 1992 36 : 1630 1634.
16. Unger C, Maniera T, Kaufman-Kolle P et al. In vivo antileishmanial activity of hexadecylphosphocholine and other alkylphosphocholines. Drugs of Today 1998 34 (suppl. F 133 140.
17. Verma NK, Dey CS. Possible mechanism of miltefosine-mediated death of Leishmania donovani. Antimicrobial Agents and Chemotherapy 2004 48 : 3010 3015.
18. Manciati F, Meciani N. Specific serodiagnosis of canine leishmaniasis by indirect immunofluorescence, indirect hemaglutination, and counter immunoelectrophoresis. American Journal of Veterinary Research 1988 49 : 1409 1411.
19. Sainz A, Delgado S, Amusategui I et al. Seroprevalence of canine ehrlichiosis in Castilla-León (North-West Spain). Preventive Veterinary Medicine 1996 29 : 1 7.
20. Van Eys GJ, Schoone GJ, Kroon NC et al. Sequence analysis of small subunit ribosomal RNA genes and its use for detection and identification of Leishmania parasites. Molecular and Biochemical Parasitology 1992 51 : 133 142.
21. Sundar S, Makharia A, More DK et al. Short-course of oral miltefosine for treatment of visceral leishmaniasis. Clinical Infectious Diseases 2000 31 : 1110 1113.
22. Bhattacharya SK, Sinha PK, Sundar S et al. Phase IV trial of miltefosine in the treatment of Indian visceral leishmaniasis. Journal of Infectious Diseases 2007 196 : 591 598.
23. Le Fichoux Y, Rousseau D, Ferrua B et al. Short- and long-term efficacy of hexadecylphosphocholine against established Leishmania infantum infection in BALB/c mice. Antimicrobial Agents and Chemotherapy 1998 32 : 654 658.
24. Miró G, Mateo M, Cruz I et al. Miltefosine: a new treatment for canine leishmaniosis. Preliminary results. Proceedings of the Third World Congress on Leishmaniosis Sicily, Italy : Palermo-Terrasini, 2005 : 175.
25. Manna A, Vitale F, Reale S et al. Study of efficacy of miltefosine and allopurinol in dogs with leishmaniosis. The Veterinary Journal 2008 DOI :. [Epub ahead of print].
26. Valladares JE, Riera C, Gonzalez-Ensenyat P et al. Long term improvement in the treatment of canine leishmaniosis using an antimony liposomal formulation. Veterinary Parasitology 2001 97 : 15 21.
27. Pasa S, Toz SO, Voyvoda H et al. Clinical and serological follow-up in dogs with visceral leishmaniosis treated with allopurinol and sodium stibogluconate. Veterinary Parasitology 2005 128 : 243 249.
28. Oliva G, Scalone A, Foglia Manzillo V et al. Incidence and time course of Leishmania infantum infections examined by parasitological, serologic, and Nested-PCR techniques in a cohort of naïve dogs exposed to three consecutive transmission seasons. Journal of Clinical Microbiology 2006 44 : 1318 1322.
29. Ikeda-García FA, Lopes RS, Marques FJ et al. Clinical and parasitological evaluation of dogs naturally infected by Leishmania (Leishmania chagasi) submitted to treatment with meglumine antimoniate. Veterinary Parasitology 2007 143 : 254 259.
30. Solano-Gallego L, Riera C, Roura X et al. Leishmania infantum-specific IgG, IgG1 and IgG2 antibody responses in healthy and ill dogs from endemic areas 2001. Evolution in the course of infection and after treatment. Veterinary Parasitology 2001 96 : 265 276.
31. Pennisi MG, De Majo M, Masucci M et al. Efficacy of the treatment of dogs with leishmaniosis with a combination of metronidazole and spiramycin. Veterinary Record 2005 156 : 346 349.