Influence of arousal threshold and depth of sleep on respiratory stability in man: Analysis using a mathematical model: Experimental Physiology-Research Paper

Experimental Physiology

Volumn 94, Issue 12, 2009, Pages 1185-1199

  Longobardo, G S ^a   Evangelisti, C J ^a   Cherniack, N S ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APNEA; AROUSAL; ARTICLE; BRAIN BLOOD FLOW; CARBON DIOXIDE TENSION; ELASTICITY; HUMAN; LUNG VENTILATION; MATHEMATICAL MODEL; OXYGEN TENSION; RESPIRATION CONTROL; SLEEP WAKING CYCLE;

EID: 73149118474     PISSN: 09580670     EISSN: 1469445X     Source Type: Journal    
DOI: 10.1113/expphysiol.2009.049007     Document Type: Article

References (34)

1. Ayappa I Rapoport DM (2003). The upper airways in sleep: physiology of the pharynx. Sleep Med Rev 7, 9 33.
2. Ayas NT, Brown R Shea SA (2000). Hypercapnia can induce arousal from sleep in the absence of altered respiratory mechanoreception. Am J Resp Crit Care Med 162, 1004 1008.
3. Berry RB, Asyali MA, McNellis MI Khoo MC (1998). Within-night variation in respiratory effort preceding apnea termination and EEG delta waves in sleep apnea. J Appl Physiol 85, 1434 1441.
4. Berry RB Gleeson K (1997). Respiratory arousal from sleep: mechanism and significance. Sleep 206, 645 675.
5. Berry RB, Kouchi KG, Der DE, Dickel MJ Light RW (1996). Sleep apnea impairs the arousal response to airway occlusion. Chest 109, 1440 1446.
6. Berry RB, McCasland CR Light RW (1992). The effect of triazolam on the arousal response to airway occlusion during sleep in normal subjects. Am Rev Respir Dis 146, 1256 1260.
7. Bradley TD, Brown IG, Grossman RF, Zamel N, Martinez D, Phillipson EA Hoffstein V (1986). Pharyngeal size in snorers, nonsnorers, and patients with obstructive sleep apnea. N Engl J Med 315, 1327 1331.
8. Cherniack NS Longobardo GS (1970). Oxygen and carbon dioxide gas stores of the body. Physiol Rev 50, 196 243.
9. Dingli K, Fietze I, Assimakopoulos T, Quispe-Bravas S, Witt C Douglas NJ (2002). Arousability in sleep apnea/hypopnea syndrome patients. Eur Resp J 20, 733 740.
10. Gleeson K, Zwillich CW White DP (1990). The influence of increasing ventilatory effort on arousal from sleep. Am Rev Respir Dis 142, 295 300.
11. Halasz P, Terazano P, Patrino L Bodizs R (2004). The nature of arousal in sleep. J Sleep Res 13, 1 23.
12. Heinzer RC, White DP, Jordan AS, Lo YL, Dover L, Stevenson K Malhotra A (2008). Trazodone increases arousal threshold in obstructive sleep apnoea. Eur Resp J 31, 1308 1312.
13. Indic P, Schwartz WP, Herzog ED, Foley NC Antle MC (2007). Modeling the behavior of coupled cellular circadian oscillators. J Biol Rhythms 22, 212 219
14. Khoo MC, Koh SS, Shin JJ, Westbrook PR Berry RB (1996). Ventilatory dynamics during transient arousal from NREM sleep: implications for respiratory control stability. J Appl Physiol 80, 1475 1484.
15. Krimsky WR Leiter JC (2005). Physiology of breathing and respiratory control during sleep. Semin Respir Crit Care Med 26, 5 12.
16. Lloyd BB, Jukes MG, Cunningham DJ (1958). The relationship between alveolar oxygen pressure and respiratory response to carbon dioxide in man. Exp Physiol Cogn Med Sci 43, 214 227.
17. Longobardo GS, Evangelisti CJ Cherniack NS (2002). Effects of neural drives on breathing in the awake state in humans. Respir Physiol 129, 317 333.
18. Longobardo GS, Evangelisti CJ Cherniack NS (2005). Introduction of a respiratory pattern generator into models of respiratory control. Respir Physiol Neurobiol 148, 285 301.
19. Longobardo GS, Evangelisti CJ Cherniack NS (2008). Analysis of the interplay between neurochemical control of respiration and upper airway mechanics producing upper airway obstruction during sleep in humans. Exp Physiol 93, 271 287.
20. Longobardo GS, Gothe B, Goldman MD Cherniack NS (1982). Sleep apnea considered as a control system instability. Respir Physiol 50, 311 333.
21. McCauley P, Kalachev BLV, Smith AD, Belenky G, Dinges DF VanDongen HP (2009). A new mathematical model for the homeostatic effects of sleep loss on neurobehavioral performance. J Theor Biol 256, 227 239.
22. Malhotra A, Pillar G, Fogel RB, Edwards JK, Ayas N, Akahoshi T, Hess D White DP (2002). Pharygeal pressure and flow effects on genioglossus activation in normal subjects. Am J Respir Crit Care Med 165, 71 77.
23. Nielsen M Smith S (1951). Studies on the regulation of respiration in acute hypoxia. Acta Physiol Scand 24, 293 313.
24. Nakao M, Karashima A Katayama N (2007). Mathematical models of regulatory mechanisms of sleep-wake rhythms. Cell Mol Life Sci 64, 1236 1243.
25. Oku Y, Saidel GM, Cherniack NS Altose MD (1996). Effects of willful ventilatory control on respiratory sensation during hypercapnia. Respiration 63, 137 143.
26. Phillips AJ Robinson PA (2007). A quantitative model of sleep-wake dynamics based on the physiology of the brainstem ascending arousal system. J Biol Rhythms 22, 167 179.
27. Remmers JE, deGroot WJ, Sauerland EK Anch AM (1998). Pathogenesis of upper airway occlusion during sleep. J Appl Physiol 44, 931 938.
28. Saunders RB Stradling T (1993). Chemoreceptor drives and short sleep waking cycles during hypoxia. A simulation. Ann Biomed Engineer 21, 465 474.
29. Terzano MG Parrino L (2000). Origin and significance of the cyclic alternating pattern (CAP). Sleep Med Rev 4, 101 123.
30. Togo F, Cherniack NS Natelson BH (2006). Electroencephalogram characteristics of autonomic arousals during sleep in healthy men. Clin Neurophysiol 117, 2597 2603.
31. Van Hirtum A, Pelorson X Lagrée PY (2005). In vitro validation of some flow assumptions for the prediction of the pressure distribution during obstructive sleep apnoea. Med Biol Eng Comput 43, 162 171.
32. White DP (2005). Pathogenesis of obstructive and central apnea. Am J Respir Crit Care Med 172, 1363 1370.
33. Younes M (2004). Role of arousals in the pathogenesis of obstructive sleep apnea. Am J Respir Crit Care Med 169, 623 633.
34. Younes M (2008). Role of respiratory control mechanisms in the pathogenesis of obstructive sleep disorders. J Appl Physiol 105, 1389 1405.