Cooperation of innate and adaptive immunity in the pathogenesis of biliary atresia: There's a killer on the run - Commentary

Hepatology

Volumn 50, Issue 6, 2009, Pages 2037-2040

  Sharland, Alexandra ^a   Gorrell, Mark D ^b  

^a UNIVERSITY OF SYDNEY   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CXCL9 CHEMOKINE; DIPEPTIDYL PEPTIDASE IV; DIPEPTIDYL PEPTIDASE IV INHIBITOR; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 DERIVATIVE; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; INTERLEUKIN 12; NATURAL KILLER CELL RECEPTOR NKG2D; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4;

ADAPTIVE IMMUNITY; APOPTOSIS; BILE DUCT ATRESIA; BILE DUCT OBSTRUCTION; BILE FLOW; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL DAMAGE; CELL MEDIATED CYTOTOXICITY; CHOLESTASIS; CYTOKINE PRODUCTION; CYTOLYSIS; DISEASE ASSOCIATION; DISEASE MODEL; GENE OVEREXPRESSION; HUMAN; INHIBITION KINETICS; INNATE IMMUNITY; INTRAHEPATIC BILE DUCT; LIVER FAILURE; LYMPHOCYTE DEPLETION; LYMPHOCYTE PROLIFERATION; NATURAL KILLER CELL; NONHUMAN; NOTE; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; ROTAVIRUS; TH1 CELL;

EID: 73149110404     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.23399     Document Type: Note

References (15)

1. Mack CL. The pathogenesis of biliary atresia: evidence for a virus-induced autoimmune disease. Semin Liver Dis 2007;27:233-242.
2. Mack CL, Falta MT, Sullivan AK, Karrer F, Sokol RJ, Freed BM, et al. Oligoclonal expansions of CD4+ and CD8+ T-cells in the target organ of patients with biliary atresia. Gastroenterology 2007;133:278-287.
3. Mack CL, Tucker RM, Sokol RJ, Kotzin BL. Armed CD4+ Th1 effector cells and activated macrophages participate in bile duct injury in murine biliary atresia. Clin Immunol 2005;115:200-209.
4. Shivakumar P, Sabla G, Mohanty S, McNeal M, Ward R, Stringer K, et al. Effector role of neonatal hepatic CD8+ lymphocytes in epithelial injury and autoimmunity in experimental biliary atresia. Gastroenterology 2007; 133:268-277.
5. Shivakumar P, Sabla GE, Whitington P, Chougnet CA, Bezerra JA. Neonatal NK cells target the mouse duct epithelium via Nkg2d and drive tissue-specific injury in experimental biliary atresia. J Clin Invest 2009; 119:2281-2290.
6. Shanker A, Verdeil G, Buferne M, Inderberg-Suso EM, Puthier D, Joly F, et al. CD8 T cell help for innate antitumor immunity. J Immunol 2007; 179:6651-6662.
7. Adam C, King S, Allgeier T, Braumuller H, Luking C, Mysliwietz J, et al. DC-NK cell cross talk as a novel CD4+ T-cell-independent pathway for antitumor CTL induction. Blood 2005;106:338-344.
8. Fan Z, Yu P, Wang Y, Wang Y, Fu ML, Liu W, et al. NK-cell activation by LIGHT triggers tumor-specific CD8+ T-cell immunity to reject established tumors. Blood 2006;107:1342-1351.
9. Eagle RA, Jafferji I, Barrow AD. Beyond stressed self: evidence for NKG2D ligand expression on healthy cells. Curr Immunol Rev 2009;5: 22-34.
10. Harada K, Sato Y, Itatsu K, Isse K, Ikeda H, Yasoshima M, et al. Innate immune response to double-stranded RNA in biliary epithelial cells is associated with the pathogenesis of biliary atresia. Hepatology 2007;46: 1146-1154.
11. Zhao J, Kim KD, Yang X, Auh S, Fu YX, Tang H. Hyper innate responses in neonates lead to increased morbidity and mortality after infection. Proc Natl Acad Sci U S A 2008;105:7528-7533.
12. Lazaridis KN, Strazzabosco M, Larusso NF. The cholangiopathies: disorders of biliary epithelia. Gastroenterology 2004;127:1565-1577.
13. Guicciardi ME, Gores GJ. Apoptosis: a mechanism of acute and chronic liver injury. Gut 2005;54:1024-1033.
14. Marzioni M, Alpini G, Saccomanno S, Candelaresi C, Venter J, Rychlicki C, et al. Exendin-4, a glucagon-like peptide 1 receptor agonist, protects cholangiocytes from apoptosis. Gut 2009;58:990-997.
15. Kirby M, Yu DM, O'Connor S, Gorrell MD. Inhibitor selectivity in the clinical application of dipeptidyl peptidase-4 inhibition. Clin Sci (Lond) 2009;118:31-41.