GMab-1, a high-affinity anti-3′-isoLM1/3′,6′-isoLD1 IgG monoclonal antibody, raised in lacto-series ganglioside-defective knockout mice

Biochemical and Biophysical Research Communications

Volumn 391, Issue 1, 2010, Pages 750-755

  Kato, Yukinari ^a,b   Kuan, Chien Tsun ^a   Chang, Jinli ^a   Kaneko, Mika Kato ^a   Ayriss, Joanne ^a   Piao, Hailan ^a   Chandramohan, Vidyalakshmi ^a   Pegram, Charles ^a   McLendon, Roger E ^a   Fredman, Pam ^c   Månsson, Jan Eric ^c   Bigner, Darell D ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b YAMAGATA UNIVERSITY   (Japan)

^c UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

3 ,6 IsoLD1; 3 IsoLM1; Knockout mice; Lacto series ganglioside; Lc3 synthase; Monoclonal antibody

Indexed keywords

GANGLIOSIDE; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN G3; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY GMAB 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY AFFINITY; ARTICLE; CONTROLLED STUDY; FUNCTIONAL ASSESSMENT; GLIOBLASTOMA; IMMUNIZATION; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIBODIES, MONOCLONAL; GANGLIOSIDES; GLIOMA; IMMUNOGLOBULIN G; MICE; MICE, KNOCKOUT; N-ACETYLGLUCOSAMINYLTRANSFERASES; TUMOR MARKERS, BIOLOGICAL;

MUS;

EID: 73149104140     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.11.132     Document Type: Article

References (20)

1. Hakomori S.I. Structure and function of glycosphingolipids and sphingolipids: recollections and future trends. Biochim. Biophys. Acta 1780 (2008) 325-346
2. Bowes T., Wagner E.R., Boffey J., Nicholl D., Cochrane L., Benboubetra M., Conner J., Furukawa K., Furukawa K., and Willison H.J. Tolerance to self gangliosides is the major factor restricting the antibody response to lipopolysaccharide core oligosaccharides in Campylobacter jejuni strains associated with Guillain-Barre syndrome. Infect. Immun. 70 (2002) 5008-5018
3. Akeboshi H., Chiba Y., Kasahara Y., Takashiba M., Takaoka Y., Ohsawa M., Tajima Y., Kawashima I., Tsuji D., Itoh K., Sakuraba H., and Jigami Y. Production of recombinant beta-hexosaminidase A, a potential enzyme for replacement therapy for Tay-Sachs and Sandhoff diseases, in the methylotrophic yeast Ogataea minuta. Appl. Environ. Microbiol. 73 (2007) 4805-4812
4. Kawashima N., Tsuji D., Okuda T., Itoh K., and Nakayama K.I. Mechanism of abnormal growth in astrocytes derived from a mouse model of GM2 gangliosidosis. J. Neurochem. 111 (2009) 1031-1041
5. Kawashima I., Nakamura O., and Tai T. Antibody responses to ganglio-series gangliosides in different strains of inbred mice. Mol. Immunol. 29 (1992) 625-632
6. Lunn M.P., Johnson L.A., Fromholt S.E., Itonori S., Huang J., Vyas A.A., Hildreth J.E., Griffin J.W., Schnaar R.L., and Sheikh K.A. High-affinity anti-ganglioside IgG antibodies raised in complex ganglioside knockout mice: reexamination of GD1a immunolocalization. J. Neurochem. 75 (2000) 404-412
7. Ozawa H., Kotani M., Kawashima I., and Tai T. Generation of one set of monoclonal antibodies specific for b-pathway ganglio-series gangliosides. Biochim. Biophys. Acta 1123 (1992) 184-190
8. Liu Y., Wada R., Kawai H., Sango K., Deng C., Tai T., McDonald M.P., Araujo K., Crawley J.N., Bierfreund U., Sandhoff K., Suzuki K., and Proia R.L. A genetic model of substrate deprivation therapy for a glycosphingolipid storage disorder. J. Clin. Invest. 103 (1999) 497-505
9. Takamiya K., Yamamoto A., Furukawa K., Yamashiro S., Shin M., Okada M., Fukumoto S., Haraguchi M., Takeda N., Fujimura K., Sakae M., Kishikawa M., Shiku H., Furukawa K., and Aizawa S. Mice with disrupted GM2/GD2 synthase gene lack complex gangliosides but exhibit only subtle defects in their nervous system. Proc. Natl. Acad. Sci. USA 93 (1996) 10662-10667
10. Okada M., Itoh Mi M., Haraguchi M., Okajima T., Inoue M., Oishi H., Matsuda Y., Iwamoto T., Kawano T., Fukumoto S., Miyazaki H., Furukawa K., Aizawa S., and Furukawa K. b-Series ganglioside deficiency exhibits no definite changes in the neurogenesis and the sensitivity to Fas-mediated apoptosis but impairs regeneration of the lesioned hypoglossal nerve. J. Biol. Chem. 277 (2002) 1633-1636
11. Okuda T., Tokuda N., Numata S., Ito M., Ohta M., Kawamura K., Wiels J., Urano T., Tajima O., Furukawa K., and Furukawa K. Targeted disruption of Gb3/CD77 synthase gene resulted in the complete deletion of globo-series glycosphingolipids and loss of sensitivity to verotoxins. J. Biol. Chem. 281 (2006) 10230-10235
12. Kondo Y., Tokuda N., Fan X., Yamashita T., Honke K., Takematsu H., Togayachi A., Ohta M., Kotzusumi Y., Narimatsu H., Tajima O., Furukawa K., and Furukawa K. Glycosphingolipids are not pivotal receptors for Subtilase cytotoxin in vivo: sensitivity analysis with glycosylation-defective mutant mice. Biochem. Biophys. Res. Commun. 378 (2009) 179-181
13. Boffey J., Nicholl D., Wagner E.R., Townson K., Goodyear C., Furukawa K., Furukawa K., Conner J., and Willison H.J. Innate murine B cells produce anti-disialosyl antibodies reactive with Campylobacter jejuni LPS and gangliosides that are polyreactive and encoded by a restricted set of unmutated V genes. J. Neuroimmunol. 152 (2004) 98-111
14. Boffey J., Odaka M., Nicoll D., Wagner E.R., Townson K., Bowes T., Conner J., Furukawa K., and Willison H.J. Characterisation of the immunoglobulin variable region gene usage encoding the murine anti-ganglioside antibody repertoire. J. Neuroimmunol. 165 (2005) 92-103
15. Henion T.R., Zhou D., Wolfer D.P., Jungalwala F.B., and Hennet T. Cloning of a mouse beta 1,3N-acetylglucosaminyltransferase GlcNAc(beta 1,3)Gal(beta 1,4)Glc-ceramide synthase gene encoding the key regulator of lacto-series glycolipid biosynthesis. J. Biol. Chem. 276 (2001) 30261-30269
16. Wikstrand C.J., He X.M., Fuller G.N., Bigner S.H., Fredman P., Svennerholm L., and Bigner D.D. Occurrence of lacto series gangliosides 3′-isoLM1 and 3′,6′-isoLD1 in human gliomas in vitro and in vivo. J. Neuropathol. Exp. Neurol. 50 (1991) 756-769
17. Wikstrand C.J., Longee D.C., McLendon R.E., Fuller G.N., Friedman H.S., Fredman P., Svennerholm L., and Bigner D.D. Lactotetraose series ganglioside 3′,6′-isoLD1 in tumors of central nervous and other systems in vitro and in vivo. Cancer Res. 53 (1993) 120-126
18. Wikstrand C.J., Fredman P., Svennerholm L., and Bigner D.D. Detection of glioma-associated gangliosides GM2, GD2, GD3, 3′-isoLM1 3′,6′-isoLD1 in central nervous system tumors in vitro and in vivo using epitope-defined monoclonal antibodies. Prog. Brain Res. 101 (1994) 213-223
19. Månsson J.E., Fredman P., Bigner D.D., Molin K., Rosengren B., Friedman H.S., and Svennerholm L. Characterization of new gangliosides of the lactotetraose series in murine xenografts of a human glioma cell line. FEBS Lett. 201 (1986) 109-113
20. R132H, the most common glioma-derived mutation. Biochem. Biophys. Res. Commun. 390 (2009) 547-551