Synthesis of functionalized pyridazin-3(2H)-ones via bromine-magnesium exchange on bromopyridazin-3(2H)-ones

Journal of Organic Chemistry

Volumn 74, Issue 24, 2009, Pages 9440-9445

  Ryabtsova, Oxana ^a   Verhelst, Tom ^a   Baeten, Mattijs ^a   Vande Velde, Christophe M L ^b   Maes, Bert U W ^a  

^a UNIVERSITY OF ANTWERP   (Belgium)

^b Karel de Grote University College   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ADDITION-ELIMINATION; BROMINE-MAGNESIUM EXCHANGE; CHEMICAL EQUATIONS; ELECTROPHILES; EXCHANGE REACTION; FUNCTIONALIZATIONS; FUNCTIONALIZED; METALATIONS; METHOXY; MODEL SUBSTRATES; NUCLEOPHILIC SUBSTITUTIONS; TANDEM REACTION;

BROMINE; SYNTHESIS (CHEMICAL);

MAGNESIUM;

BROMINE; ELECTROPHILE; HALOGEN; MAGNESIUM; NUCLEOPHILE; PYRIDAZINE DERIVATIVE;

ADDITION REACTION; ARTICLE; CHEMICAL REACTION; ELIMINATION REACTION; HYDROLYSIS; REACTION TIME; SUBSTITUTION REACTION; SYNTHESIS;

BROMINE; HYDROCARBONS, BROMINATED; MAGNESIUM; MODELS, CHEMICAL; PYRIDAZINES; PYRIDONES;

EID: 73149102320     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo9020985     Document Type: Article

References (40)

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40. A Scifinder database search revealed that 70% of the molecules synthesized in this manuscript (with the specific substituents on C-4 and C-5 shown in the tables, schemes and figures, leaving the N-2 and C-6 substituents undefined) were hitherto unknown.