Structural insight into the interaction of proteins containing NPF, DPF, and GPF motifs with the C-terminal EH-domain of EHD1

Protein Science

Volumn 18, Issue 12, 2009, Pages 2471-2479

  Kieken, Fabien ^a   Jović, Marko ^a   Tonelli, Marco ^b   Naslavsky, Naava ^a   Caplan, Steve ^a   Sorgen, Paul L ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

EH domain; EHD1; Endocytic transport; NPF motif

Indexed keywords

ASPARAGINYLPROLYLPHENYLALANINE; ASPARTYLPROLYLPHENYLALANINE; GLYCYLPROLYLPHENYLALANINE; TRIPEPTIDE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; HYDROGEN BOND; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION;

AMINO ACID MOTIFS; HUMANS; MODELS, MOLECULAR; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PEPTIDES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; VESICULAR TRANSPORT PROTEINS;

EID: 73149101304     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1002/pro.258     Document Type: Article

References (36)

1. Santolini E, Salcini AE, Kay BK, Yamabhai M, Di Fiore PP (1999) The EH network. Exp Cell Res 253:186-209.
2. Fazioli F, Minichiello L, Matoskova B, Wong WT, Di Fiore PP (1993) eps15, a novel tyrosine kinase substrate, exhibits transforming activity. Mol Cell Biol 13:5814-5828.
3. Wong WT, Schumacher C, Salcini AE, Romano A, Castagnino P, Pelicci PG, Di Fiore PP (1995) A protein-binding domain, EH, identified in the receptor tyrosine kinase substrate Eps15 and conserved in evolution. Proc Natl Acad Sci USA 92:9530-9534.
4. Paoluzi S, Castagnoli L, Lauro I, Salcini AE, Coda L, Fre S, Confalonieri S, Pelicci PG, Di Fiore PP, Cesareni G (1998) Recognition specificity of individual EH domains of mammals and yeast. EMBO J 17:6541-6550.
5. Salcini AE, Chen H, Iannolo G, De Camilli P, Di Fiore PP (1999) Epidermal growth factor pathway substrate 15, Eps15. Int J Biochem Cell Biol 31:805-809.
6. Miliaras NB, Wendland B (2004) EH proteins: multivalent regulators of endocytosis (and other pathways). Cell Biochem Biophys 41:295-318.
7. Polo S, Confalonieri S, Salcini AE, Di Fiore PP (2003) EH and UIM: endocytosis and more. Sci STKE 2003:re17.
8. Grant BD, Caplan S (2008) Mechanisms of EHD/RME-1 protein function in endocytic transport. Traffic 9:2043-2052.
9. Naslavsky N, Caplan S (2005) C-terminal EH-domain-containing proteins: consensus for a role in endocytic trafficking, EH?J Cell Sci 118:4093-4101.
10. Blume JJ, Halbach A, Behrendt D, Paulsson M, Plomann M (2007) EHD proteins are associated with tubular and vesicular compartments and interact with specific phospholipids. Exp Cell Res 313:219-231.
11. Caplan S, Naslavsky N, Hartnell LM, Lodge R, Polishchuk RS, Donaldson JG, Bonifacino JS (2002) A tubular EHD1-containing compartment involved in the recycling of major histocompatibility complex class I molecules to the plasma membrane. EMBO J 21:2557-2567.
12. George M, Ying G, Rainey MA, Solomon A, Parikh PT, Gao Q, Band V, Band H (2007) Shared as well as distinct roles of EHD proteins revealed by biochemical and functional comparisons in mammalian cells and C. elegans. BMC Cell Biol 8:3.
13. Grant B, Zhang Y, Paupard MC, Lin SX, Hall DH, Hirsh D (2001) Evidence that RME-1, a conserved C. elegans EH-domain protein, functions in endocytic recycling. Nat Cell Biol 3:573-579.
14. Jovic M, Naslavsky N, Rapaport D, Horowitz M, Caplan S (2007) EHD1 regulates beta1 integrin endosomal transport: effects on focal adhesions, cell spreading and migration. J Cell Sci 120:802-814.
15. Lin SX, Grant B, Hirsh D, Maxfield FR (2001) Rme-1 regulates the distribution and function of the endocytic recycling compartment in mammalian cells. Nat Cell Biol 3:567-572.
16. Naslavsky N, Rahajeng J, Rapaport D, Horowitz M, Caplan S (2007) EHD1 regulates cholesterol homeostasis and lipid droplet storage. Biochem Biophys Res Commun 357:792-799.
17. Naslavsky N, McKenzie J, Altan-Bonnet N, Sheff D, Caplan S (2009) EHD3 regulates early-endosome-to-Golgi transport and preserves Golgi morphology. J Cell Sci 122:389-400.
18. Park M, Penick EC, Edwards JG, Kauer JA, Ehlers MD (2004) Recycling endosomes supply AMPA receptors for LTP. Science 305:1972-1975.
19. Sharma M, Naslavsky N, Caplan S (2008) A role for EHD4 in the regulation of early endosomal transport. Traffic 9:995-1018.
20. Braun A, Pinyol R, Dahlhaus R, Koch D, Fonarev P, Grant BD, Kessels MM, Qualmann B (2005) EHD proteins associate with syndapin I and II and such interactions play a crucial role in endosomal recycling. Mol Biol Cell 16:3642-3658.
21. Naslavsky N, Boehm M, Backlund PS, Jr., Caplan S (2004) Rabenosyn-5 and EHD1 interact and sequentially regulate protein recycling to the plasma membrane. Mol Biol Cell 15:2410-2422.
22. Naslavsky N, Rahajeng J, Sharma M, Jovic M, Caplan S (2006) Interactions between EHD proteins and Rab11-FIP2: a role for EHD3 in early endosomal transport. Mol Biol Cell 17:163-177.
23. Shi A, Pant S, Balklava Z, Chen CC, Figueroa V, Grant BD (2007) A novel requirement for C. elegans Alix/ALX-1 in RME-1-mediated membrane transport. Curr Biol 17:1913-1924.
24. Smith CA, Dho SE, Donaldson J, Tepass U, McGlade CJ (2004) The cell fate determinant numb interacts with EHD/Rme-1 family proteins and has a role in endocytic recycling. Mol Biol Cell 15:3698-3708.
25. Xu Y, Shi H, Wei S, Wong SH, Hong W (2004) Mutually exclusive interactions of EHD1 with GS32 and syndapin II. Mol Membr Biol 21:269-277.
26. Confalonieri S, Di Fiore PP (2002) The Eps15 homology (EH) domain. FEBS Lett 513:24-29.
27. de Beer T, Carter RE, Lobel-Rice KE, Sorkin A, Overduin M (1998) Structure and Asn-Pro-Phe binding pocket of the Eps15 homology domain. Science 281:1357-1360.
28. Kieken F, Jovic M, Naslavsky N, Caplan S, Sorgen PL (2007) EH domain of EHD1. J Biomol NMR 39:323-329.
29. Daumke O, Lundmark R, Vallis Y, Martens S, Butler PJ, McMahon HT (2007) Architectural and mechanistic insights into an EHD ATPase involved in membrane remodelling. Nature 449:923-927.
30. de Beer T, Hoofnagle AN, Enmon JL, Bowers RC, Yamabhai M, Kay BK, Overduin M (2000) Molecular mechanism of NPF recognition by EH domains. Nat Struct Biol 7:1018-1022.
31. Kim S, Cullis DN, Feig LA, Baleja JD (2001) Solution structure of the Reps1 EH domain and characterization of its binding to NPF target sequences. Biochemistry 40:6776-6785.
32. Santonico E, Panni S, Falconi M, Castagnoli L, Cesareni G (2007) Binding to DPF-motif by the POB1 EH domain is responsible for POB1-Eps15 interaction. BMC Biochem 8:29.
33. Rumpf J, Simon B, Jung N, Maritzen T, Haucke V, Sattler M, Groemping Y (2008) Structure of the Eps15-stonin2 complex provides a molecular explanation for EH-domain ligand specificity. EMBO J 27:558-569.
34. Linge JP, O'Donoghue SI, Nilges M (2001) Automated assignment of ambiguous nuclear overhauser effects with ARIA. Methods Enzymol 339:71-90.
35. Laskowski RA, Rullmannn JA, MacArthur MW, Kaptein R, Thornton JM (1996) AQUA and PROCHECK-NMR: programs for checking the quality of protein structures solved by NMR. J Biomol NMR 8:477-486.
36. Koradi R, Billeter M, Wuthrich K (1996) MOLMOL: a program for display and analysis of macromolecular structures. J Mol Graph 14:51-55,29-32.