Calcium signaling in neuronal cells exposed to the munitions compound cyclotrimethylenetrinitramine (RDX)

International Journal of Toxicology

Volumn 28, Issue 5, 2009, Pages 425-435

  Ehrich, Marion ^a   Wu, Xiaohua ^a   Were, Stephen R ^a   Major, Michael A ^b   McCain, Wilfred C ^b   Reddy, Gunda ^b  

^a VIRGINIA MARYLAND REGIONAL COLLEGE OF VETERINARY MEDICINE   (United States)

^b U S ARMY CENTER FOR HEALTH PROMOTION AND PREVENTIVE MEDICINE   (United States)

Author keywords

Calcium; Carbachol; Human neuroblastoma cells; RDX; SH SY5Y cells

Indexed keywords

CALCIUM CHANNEL; CALCIUM ION; CARBACHOL; CYCLONITE; EGTAZIC ACID; LIDOCAINE; THAPSIGARGIN; VERAPAMIL;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CHANNEL GATING; CONCENTRATION RESPONSE; CONTROLLED STUDY; EXCITOTOXICITY; FLUORESCENCE; HUMAN; HUMAN CELL; NEUROBLASTOMA CELL; NEUROTOXICITY;

CALCIUM; CALCIUM CHANNEL BLOCKERS; CALCIUM SIGNALING; CELL CULTURE TECHNIQUES; CELL LINE, TUMOR; CELL MEMBRANE; CELL SURVIVAL; CHELATING AGENTS; CULTURE MEDIA, SERUM-FREE; EGTAZIC ACID; EXPLOSIVE AGENTS; HUMANS; NEURONS; TRIAZINES;

ANIMALIA; TETRA;

EID: 73149092993     PISSN: 10915818     EISSN: 1092874X     Source Type: Journal    
DOI: 10.1177/1091581809340331     Document Type: Article

References (33)

1. Bannon DI, Dillman JF, Hable MA, et al. Global gene expression in rat brain and liver after oral exposure to the explosive hexahydro-1,3,5-trinitro-1, 3,5-triazine (RDX). Chem Res Toxicol. 2009;22:620-625.
2. McLellan WL, Harley WR, Brown ME. Hexahydro-1,3,5- trinitro-1,3,5- triazine (RDX). In: Roberts WC, Hartley WR, eds. Drinking Water Health Advisory: Munitions. United States Environmental Protection Agency. Boca Raton, FL: Lewis; 1992:133-180.
3. Crouse LC, Michie MW, Major MA, et al. Oral bioavailability of cyclotrimethylenetrinitramine (RDX) from contaminated site soils in rats. Int J Toxicol. 2008;27:317-322.
4. Major MA. Biological degradation of explosives. In: Bioremediation of Contaminated Soil. American Society of Agronomy, Crop Science Society of America, Soil Society of America. Madison, WI: American Society of Agronomy; 1999. Monograph No. 37.
5. Perchet G, Merlina G, Revel JC, et al. Evaluation of a TiO2 photocatalysis treatment on nitrophenols and nitramines contaminated plant wastewaters by solid-phase extraction coupled with ESI HPLC-MS. J Hazard Mater. 2009;166:284-290.
6. Reifenrath WG, Kammen HO, Reddy G, et al. Interaction of hydration, aging, and carbon content of soil on the evaporation and skin bioavailability of munition contaminants. J Toxicol Environ Health A. 2008;71:486-494.
7. Walsh ME, Jenkins TF. Identification of TNT transformation products. In: U.S. Army Corps of Engineers Cold Regions Research and Engineering Laboratory Soil Special Report 92-116 Hanover, NH: United States Army; 1992.
8. Major MA, Reddy G, Berge MA, et al. Metabolite profiling of [14C]hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) in Yucatan miniature pigs. J Toxicol Environ Health A. 2007;70:1191-1202.
9. Schneider NR, Bradley SL, Andersen ME. Toxicology of cyclotrimethylenetrinitramine: distribution and metabolism in the rat and miniature swine. Toxicol Appl Pharmacol. 1977;39:531-541.
10. Burdette LJ, Cook LL, Dyer RS. Convulsant properties of cyclotrimethylenetrinitramine (RDX): spontaneous, audiogenic, and amygdaloid kindled seizure activity. Toxicol Appl Pharmacol. 1988;92:436-444.
11. Gibbs JW, McNamara JO. The epilepsies: phenotype and mechanisms. In: Siegel GJ, Albers RW, Brady ST, Price DL, eds. Basic Neurochemistry, Molecular, Cellular, and Medical Aspects. 7th ed. Amsterdam, The Netherlands: Elsevier Academic; 2006:619-638.
12. Gregus Z. Mechanisms of toxicity. In: Klaassen C, ed. Casarett & Doull's Toxicology, the Basic Science of Poisons. 7th ed. New York, NY: McGraw Hill; 2008:45-106.
13. Nestler EJ, Hyman SE, Malenka RC. Molecular Neuropharmacology: A Foundation for Clinical Neuroscience. New York, NY: McGraw Hill Medical; 2001.
14. Gao M, Zhang W, Liu A, et al. Pinocembrin prevents glutamate-induced apoptosis in SH-SY5Y neuronal cells via decrease of bax/bcl-2 ratio. Eur J Pharmacol. 2008;591:73-79.
15. Naarala J, Nykvist P, Tuomala M, et al. Excitatory amino acid-induced slow biphasic responses of free intracellular calcium in human neuroblastoma cells. FEBS Letters. 1993;330:222-226.
16. Carlson K, Ehrich M. Human neuroblastoma cell viability and growth are affected by altered culture conditions. In Vitr Mol Toxicol. 2000;13:249-262.
17. Ehrich M, Sharova L. In vitro methods for detecting cytotoxicity. In: Maines M, ed. Current Protocols in Toxicology. New York, NY: John Wiley; 2000:2.6.1-2.6.27.
18. Rowles T, Song X, Ehrich M. Identification of endpoints affected by exposure of human neuroblastoma cells to neurotoxicants at concentrations below those that affect cell viability. In Vitro Toxicol. 1995;8:3-13.
19. Carlson K, Ehrich M. Organophosphorus compoundinduced modification of SH-SY5Y human neuroblastoma mitochondrial transmembrane potential. Toxicol Appl Pharmacol. 1999;160:33-42.
20. Sorensen IF, Purup S, Ehrich M. Modulation of neurotoxicant-induced increases in intracellular calcium by phytoestrogens differ for amyloid beta peptide (Ab) and 1-methyl-4-phenyl-pyridine (MPP+). J Appl Toxico. l. 2009;29:84-89.
21. Wang XJ, Xu JX. Possible involvement of Ca2+ signaling in rotenone-induced apoptosis in human neuroblastoma SH-SY5Y cells. Neurosci Lett. 2005;376:127-132.
22. Molecular Probes Invitrogen Detection Technologies. Fluo-4 NW calcium assay kits product information (for microplate reader determination of calcium); 2005. http://www.invitrogen.com. Accessed July 12, 2005.
23. Li XH, WuYJ. Characteristics of lysophosphatidylcholineinduced Ca2+reponse in human neuroblastoma SH-SY5Y cells. Life Sci. 2007;80:886-892.
24. Gallego-Sandin S, Novalbos J, Rosado A, et al. Albumin prevents mitochondrial depolarization and apoptosis elicited by endoplasmic reticulum calcium depletion of neuroblastoma cells. Eur J Pharmacol. 2005;520:1-11.
25. Carlson K, Jortner BS, Ehrich M. Organophosphorus compound-induced apoptosis in SH-SY5Y human neuroblastoma cells. Toxicol Appl Pharmacol. 2000;168:112-113.
26. Tiffany-Castiglioni E, Ehrich M, Dees L, et al. Bridging the gap between in vitro and in vivo models for neurotoxicology. Toxicol Sci. 1999;51:178-183.
27. Ehrich M, Wu X, Reddy G, et al. Cyclotrimethylenetrinitramine (RDX) can increase calcium fluorescence in human neuroblastoma cells. Toxicol Sci (Toxicologist). 2007;96S:35.
28. Ehrich M, Intropido L, Costa LG. Interactions of organophosphorus compounds with muscarinic receptors in SH-SY5Y human neuroblastoma cells. J Toxicol Environ Hlth. 1994;43:51-63.
29. Barber D, Correll L, Ehrich M. Comparison of two in vitro activation systems for protoxicant organophosphorous esterase inhibitors. Toxicol Sci. 1999;47: 16-22.
30. Ehrich M, Veronesi B. In vitro neurotoxicity. In: Tilson HA, Harry, GJ, ed. Neurotoxicology. 2nd ed. Target Organ Toxicology Series (Hayes AW, Thomas JA, Gardner DE, eds). Philadelphia, PA: Taylor & Francis; 1999:37-51.
31. Brown JA, Nijjar MS. The release of glutamate and aspartate from rat brain synaptosomes in response to domoic acid (amnesic shellfish toxin) and kainic acid. Mol Cell Biochem. 1995;1151:49-54.
32. Singh J, Kaur G. Transcriptional regulation of polysialyated neural cell adhesion molecule expression by NMDA receptor activation in retinoic aciddifferentiated SH-SY5Y neuroblastoma cultures. Brain Res. 2007;1154:8-21.
33. van den Beukel I, van Kleef RG, Oortgiesen M. Differential effects of physostigmine and organophosphates on nicotinic receptors in neuronal cells of different species. Neurotoxicology. 1998;19:777-787.