Effect of Beta-Blocker Therapy on Rehospitalization Rates in Women Versus Men With Heart Failure and Preserved Ejection Fraction

American Journal of Cardiology

Volumn 105, Issue 2, 2010, Pages 229-234

  Farasat, S Morteza ^a   Bolger, Dennis T ^b   Shetty, Veena ^a   Menachery, Elizabeth P ^b   Gerstenblith, Gary ^b   Kasper, Edward K ^b   Najjar, Samer S ^c  

^a MEDSTAR RESEARCH INSTITUTE   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; AMIODARONE; ANGIOTENSIN RECEPTOR ANTAGONIST; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; DIGOXIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; NITRATE; SPIRONOLACTONE; WARFARIN;

AFRICAN AMERICAN; AGED; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; HEART FAILURE; HEART LEFT VENTRICLE EJECTION FRACTION; HOSPITAL DISCHARGE; HOSPITAL READMISSION; HUMAN; MAJOR CLINICAL STUDY; MALE; OBSERVATIONAL STUDY; PREDICTION; PRIORITY JOURNAL; PROSPECTIVE STUDY; SEX DIFFERENCE;

ADRENERGIC BETA-ANTAGONISTS; AGED; AGED, 80 AND OVER; FEMALE; FOLLOW-UP STUDIES; HEART FAILURE; HUMANS; MALE; MIDDLE AGED; PATIENT DISCHARGE; PATIENT READMISSION; PROSPECTIVE STUDIES; RISK FACTORS; SEX FACTORS; STROKE VOLUME;

EID: 73149089725     PISSN: 00029149     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.amjcard.2009.09.008     Document Type: Article

References (29)

1. McKee P.A., Castelli W.P., McNamara P.M., and Kannel W.B. The natural history of congestive heart failure: the Framingham study. N Engl J Med 285 (1971) 1441-1446
2. Vasan R.S., and Benjamin E.J. Diastolic heart failure-no time to relax. N Engl J Med 344 (2001) 56-59
3. Zile M.R., Baicu C.F., and Gaasch W.H. Diastolic heart failure-abnormalities in active relaxation and passive stiffness of the left ventricle. N Engl J Med 350 (2004) 1953-1959
4. Aurigemma G.P., Zile M.R., and Gaasch W.H. Contractile behavior of the left ventricle in diastolic heart failure: with emphasis on regional systolic function. Circulation 113 (2006) 296-304
5. Burkhoff D., Maurer M.S., and Packer M. Heart failure with a normal ejection fraction: is it really a disorder of diastolic function?. Circulation 107 (2003) 656-658
6. Zile M.R., and Lewinter M.M. Left ventricular end-diastolic volume is normal in patients with heart failure and a normal ejection fraction: a renewed consensus in diastolic heart failure. J Am Coll Cardiol 49 (2007) 982-985
7. Maurer M.S., Burkhoff D., Fried L.P., Gottdiener J., King D.L., and Kitzman D.W. Ventricular structure and function in hypertensive participants with heart failure and a normal ejection fraction: the Cardiovascular Health Study. J Am Coll Cardiol 49 (2007) 972-981
8. Kitzman D.W. Diastolic dysfunction: one piece of the heart failure with normal ejection fraction puzzle. Circulation 117 (2008) 2044-2046
9. Borlaug B.A., Melenovsky V., Russell S.D., Kessler K., Pacak K., Becker L.C., and Kass D.A. Impaired chronotropic and vasodilator reserves limit exercise capacity in patients with heart failure and a preserved ejection fraction. Circulation 114 (2006) 2138-2147
10. Hundley W.G., Kitzman D.W., Morgan T.M., Hamilton C.A., Darty S.N., Stewart K.P., Herrington D.M., Link K.M., and Little W.C. Cardiac cycle-dependent changes in aortic area and distensibility are reduced in older patients with isolated diastolic heart failure and correlate with exercise intolerance. J Am Coll Cardiol 38 (2001) 796-802
11. Kawaguchi M., Hay I., Fetics B., and Kass D.A. Combined ventricular systolic and arterial stiffening in patients with heart failure and preserved ejection fraction: implications for systolic and diastolic reserve limitations. Circulation 107 (2003) 714-720
12. Maurer M.S., Kronzon I., and Burkhoff D. Ventricular pump function in heart failure with normal ejection fraction: insights from pressure-volume measurements. Prog Cardiovasc Dis 49 (2006) 182-195
13. Melenovsky V., Borlaug B.A., Rosen B., Hay I., Ferruci L., Morell C.H., Lakatta E.G., Najjar S.S., and Kass D.A. Cardiovascular features of heart failure with preserved ejection fraction versus nonfailing hypertensive left ventricular hypertrophy in the urban Baltimore community: the role of atrial remodeling/dysfunction. J Am Coll Cardiol 49 (2007) 198-207
14. Kitzman D.W., and Groban L. Exercise intolerance. Heart Fail Clin 4 (2008) 99-115
15. Hunt S.A., Abraham W.T., Chin M.H., Feldman A.M., Francis G.S., Ganiats T.G., Jessup M., Konstam M.A., Mancini D.M., Michl K., Oates J.A., Rahko P.S., Silver M.A., Stevenson L.W., and Yancy C.W. ACC/AHA 2005 guideline update for the diagnosis and management of chronic heart failure in the adult: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2001 Guidelines for the Evaluation and Management of Heart Failure). American College of Cardiology Web Site. http://www.acc.org/clinical/guidelines/failure//index.pdf Accessed March 20, 2009
16. Aronow W.S., Ahn C., and Kronzon I. Effect of propranolol versus no propranolol on total mortality plus nonfatal myocardial infarction in older patients with prior myocardial infarction, congestive heart failure, and left ventricular ejection fraction >or = 40% treated with diuretics plus angiotensin-converting enzyme inhibitors. Am J Cardiol 80 (1997) 207-209
17. Flather M.D., Shibata M.C., Coats A.J., Van Veldhuisen D.J., Parkhomenko A., Borbola J., Cohen-Solal A., Dumitrascu D., Ferrari R., Lechat P., Soler-Soler J., Tavazzi L., Spinarova L., Toman J., Bohm M., Anker S.D., Thompson S.G., and Poole-Wilson P.A. Randomized trial to determine the effect of nebivolol on mortality and cardiovascular hospital admission in elderly patients with heart failure (SENIORS). Eur Heart J 26 (2005) 215-225
18. van Veldhuisen D.J., Cohen-Solal A., Bohm M., Anker S.D., Babalis D., Roughton M., Coats A.J., Poole-Wilson P.A., and Flather M.D. Beta-blockade with nebivolol in elderly heart failure patients with impaired and preserved left ventricular ejection fraction: data from SENIORS (Study of Effects of nebivolol Intervention on Outcomes and Rehospitalization in Seniors With Heart Failure). J Am Coll Cardiol 53 (2009) 2150-2158
19. Lewis B.S., Shotan A., Gottlieb S., Behar S., Halon D.A., Boyko V., Leor J., Grossman E., Zimlichman R., Porath A., Mittelman M., Caspi A., and Garty M. Late mortality and determinants in patients with heart failure and preserved systolic left ventricular function: the Israel nationwide heart failure survey. Isr Med Assoc J 9 (2007) 234-238
20. Fonarow G.C., Stough W.G., Abraham W.T., Albert N.M., Gheorghiade M., Greenberg B.H., O'Connor C.M., Sun J.L., Yancy C.W., and Young J.B. Characteristics, treatments, and outcomes of patients with preserved systolic function hospitalized for heart failure: a report from the OPTIMIZE-HF Registry. J Am Coll Cardiol 50 (2007) 768-777
21. Hernandez A.F., Hammill B.G., O'Connor C.M., Schulman K.A., Curtis L.H., and Fonarow G.C. Clinical effectiveness of beta-blockers in heart failure: findings from the OPTIMIZE-HF (Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure) Registry. J Am Coll Cardiol 53 (2009) 184-192
22. Massie B.M. Irbesartan for heart failure with preserved ejection fraction. N Engl J Med 360 (2009) 1258-1259
23. Ting C.T., Brin K.P., Lin S.J., Wang S.P., Chang M.S., Chiang B.N., and Yin F.C. Arterial hemodynamics in human hypertension. J Clin Invest 78 (1986) 1462-1471
24. Fleg J.L., O'Connor F., Gerstenblith G., Becker L.C., Clulow J., Schulman S.P., and Lakatta E.G. Impact of age on the cardiovascular response to dynamic upright exercise in healthy men and women. J Appl Physiol 78 (1995) 890-900
25. Kitzman D.W., Higginbotham M.B., Cobb F.R., Sheikh K.H., and Sullivan M.J. Exercise intolerance in patients with heart failure and preserved left ventricular systolic function: failure of the Frank-Starling mechanism. J Am Coll Cardiol 17 (1991) 1065-1072
26. Gatzka C.D., Kingwell B.A., Cameron J.D., Berry K.L., Liang Y.L., Dewar E.M., Reid C.M., Jennings G.L., and Dart A.M. Gender differences in the timing of arterial wave reflection beyond differences in body height. J Hypertens 19 (2001) 2197-2203
27. Borlaug B.A., Melenovsky V., Redfield M.M., Kessler K., Chang H.J., Abraham T.P., and Kass D.A. Impact of arterial load and loading sequence on left ventricular tissue velocities in humans. J Am Coll Cardiol 50 (2007) 1570-1577
28. Luzier A.B., Killian A., Wilton J.H., Wilson M.F., Forrest A., and Kazierad D.J. Gender-related effects on metoprolol pharmacokinetics and pharmacodynamics in healthy volunteers. Clin Pharmacol Ther 66 (1999) 594-601
29. McMurray J.J., Carson P.E., Komajda M., McKelvie R., Zile M.R., Ptaszynska A., Staiger C., Donovan J.M., and Massie B.M. Heart failure with preserved ejection fraction: clinical characteristics of 4133 patients enrolled in the I-PRESERVE trial. Eur J Heart Fail 10 (2008) 149-156