Mitotic exit in mammalian cells

Molecular Systems Biology

Volumn 5, Issue , 2009, Pages

  Kapuy, Orsolya ^a   He, Enuo ^a   Uhlmann, Frank ^b   Novák, Béla ^b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN B; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 1; FLAVOPIRIDOL; PROTEIN; PROTEIN TYROSINE PHOSPHATASE; PROTEIN WEE1; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE; CELL CYCLE G1 PHASE; ENZYME ACTIVITY; ENZYME INHIBITION; EUKARYOTIC CELL; HUMAN; MAMMAL CELL; METAPHASE; MITOSIS; MOLECULAR BIOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; ANIMAL; CELL; CYTOLOGY; ENZYMOLOGY; LETTER; MAMMAL; METABOLISM; PHOSPHORYLATION;

MAMMALIA;

ANIMALS; CDC2 PROTEIN KINASE; CELLS; MAMMALS; MITOSIS; PHOSPHORYLATION;

EID: 73149083973     PISSN: 17444292     EISSN: 17444292     Source Type: Journal    
DOI: 10.1038/msb.2009.86     Document Type: Article

References (10)

1. Lodish H, Berk A, Matsudaira P, Kaiser CA, Krieger M, Scott MP, Zipusky L, Darnel J (2004) Molecular Cell Biology, 5th edn, New York: Freeman
2. Lopez-Aviles S, Kapuy O, Novak B, Uhlmann F (2009) Irreversibility of mitotic exit is the consequence of systems-level feedback. Nature 459: 592-595
3. Mochida S, Hunt T (2007) Calcineurin is required to release Xenopus egg extracts from meiotic M phase. Nature 449: 336-340
4. Morgan DO (2007) The Cell Cycle: Principles of Control. London: New Science Press
5. Novak B, Tyson JJ, Gyorffy B, Csikasz-Nagy A (2007) Irreversible cellcycle transitions are due to systems-level feedback. Nat Cell Biol 9: 724-728
6. Potapova TA, Daum JR, Byrd KS, Gorbsky GJ (2009) Fine tuning the cell cycle: activation of the Cdk1 inhibitory phosphorylation pathway during mitotic exit. Mol Biol Cell 20: 1737-1748
7. Potapova TA, Daum JR, Pittman BD, Hudson JR, Jones TN, Satinover DL, Stukenberg PT, Gorbsky GJ (2006) The reversibility of mitotic exit in vertebrate cells. Nature 440: 954-958
8. Skoufias DA, Indorato RL, Lacroix F, Panopoulos A, Margolis RL (2007) Mitosis persists in the absence of Cdk1 activity when proteolysis or protein phosphatase activity is suppressed. J Cell Biol 179: 671-685
9. Tyson JJ, Chen KC, Novak B (2003) Sniffers, buzzers, toggles and blinkers: dynamics of regulatory and signaling pathways in the cell. Curr Opin Cell Biol 15: 221-231
10. Wu JQ, Guo JY, Tang W, Yang CS, Freel CD, Chen C, Nairn AC, Kornbluth S (2009) PP1-mediated dephosphorylation of phosphoproteins at mitotic exit is controlled by inhibitor-1 and PP1 phosphorylation. Nat Cell Biol 11: 644-651