The cost-effectiveness of macrogol 3350 compared to lactulose in the treatment of adults suffering from chronic constipation in the UK

Alimentary Pharmacology and Therapeutics

Volumn 31, Issue 2, 2010, Pages 302-312

  Taylor, R R ^a   Guest, J F ^a,b  

^a CATALYST Health Economics Consultants   (United Kingdom)

^b UNIVERSITY OF SURREY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

LACTULOSE; LAXATIVE; MACROGOL 3350;

ADULT DISEASE; AGED; ARTICLE; CHRONIC DISEASE; CONSTIPATION; CONTROLLED STUDY; COST EFFECTIVENESS ANALYSIS; DRUG COST; DRUG EFFICACY; DRUG SUBSTITUTION; DRUG WITHDRAWAL; FEMALE; HEALTH CARE UTILIZATION; HEALTH STATUS; HUMAN; MAJOR CLINICAL STUDY; MALE; MONOTHERAPY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; QUALITY OF LIFE; TREATMENT DURATION; UNITED KINGDOM;

ADULT; AGED; CHRONIC DISEASE; CONSTIPATION; COST-BENEFIT ANALYSIS; FEMALE; GREAT BRITAIN; HUMANS; LACTULOSE; LAXATIVES; MALE; MIDDLE AGED; MODELS, ECONOMIC; NATIONAL HEALTH PROGRAMS; POLYETHYLENE GLYCOLS; QUALITY OF LIFE; TREATMENT OUTCOME;

EID: 72949115063     PISSN: 02692813     EISSN: 13652036     Source Type: Journal    
DOI: 10.1111/j.1365-2036.2009.04191.x     Document Type: Article

References (24)

1. Thompson WG, Longstreth GF, Drossman DA, Heaton KW, Irvine EJ, Müller-Lissner SA. Functional bowel disorders and functional abdominal pain. Gut 1999 45 (Suppl 2 II43 7.
2. Sonnenberg A, Koch TR. Epidemiology of constipation in the United States. Dis Colon Rectum 1989 32 : 1 8.
3. Tytgat GN, Heading RC, Müller-Lissner S, et al. Contemporary understanding and management of reflux and constipation in the general population and pregnancy: a consensus meeting. Aliment Pharmacol Ther 2003 18 : 291 301.
4. Higgins PD, Johanson JF. Epidemiology of constipation in North America: a systematic review. Am J Gastroenterol 2004 99 : 750 759.
5. Tramonte SM, Brand MB, Mulrow CD, Amato MG, O'Keefe ME, Ramirez G. The treatment of chronic constipation in adults. A systematic review. J Gen Intern Med 1997 12 : 15 24.
6. The Health Improvement Network (THIN) Database. London : EPIC, 2008.
7. Hippisley-Cox J, Coupland C, Vinogradova Y, Robson J, Brindle P. Performance of the QRISK cardiovascular risk prediction algorithm in an independent UK sample of patients from general practice: a validation study. Heart 2008 94 : 34 9.
8. Christie AH, Culbert P, Guest JF. The economic impact of low dose polyethylene glycol 3350 plus electrolytes compared to lactulose in the management of idiopathic constipation in the UK. PharmacoEconomics 2002 20 : 49 60.
9. Guest JF, Varney SJ. Pharmacoeconomic impact of low-dose macrogol 3350 plus electrolytes compared with lactulose in the management of chronic idiopathic constipation among ambulant patients in Belgium. Clin Drug Investig 2004 24 : 719 729.
10. Guest JF, Clegg JP, Helter MT. Cost-effectiveness of macrogol 4000 compared to lactulose in the treatment of chronic functional constipation in the UK. Curr Med Res Opin 2008 24 : 1841 1852.
11. Curtis L. Unit costs of health and social care 2008. Canterbury : University of Kent, Personal Social Services Research Unit, 2009.
12. Department of Health. NHS Reference costs 2007/08. Available at: http://www.dh.gov.uk.
13. Drug Tariff. Available at: http://www.drugtariff.com.
14. British National Formulary. Available at: http://www.bnf.org.
15. Norton C. Constipation in older patients: effects on quality of life. Br J Nurs 2006 15 : 188 192.
16. Johanson JF, Kralstein J. Chronic constipation: a survey of the patient perspective. Aliment Pharmacol Ther 2007 25 : 599 608.
17. Wald A, Scarpignato C, Müeller-Lissner S, et al. A multinational survey of prevalence and patterns of laxative use among adults with self-defined constipation. Aliment Pharmacol Ther 2008 28 : 917 930.
18. The Information Centre for Health and Social Care 2009. Prescription cost analysis: England 2007. Available at: http://www.ic.nhs.uk/statistics-and-data- collections.
19. Dennison C, Prasad M, Lloyd A, Bhattacharyya SK, Dhawan R, Coyne K. The health-related quality of life and economic burden of constipation. PharmacoEconomics 2005 23 : 461 476.
20. Wald A, Scarpignato C, Kamm MA, et al. Burden of constipation on quality of life: results of a multinational survey. Aliment Pharmacol Ther 2007 26 : 227 236.
21. Attar A, Lémann M, Ferguson A, et al. Comparison of a low dose polyethylene glycol electrolyte solution with lactulose for treatment of chronic constipation. Gut 1999 44 : 226 230.
22. Hammerschmidt T, Zeitler HP, Gulich M, Leidl R. A comparison of different strategies to collect standard gamble utilities. Med Decis Making 2004 24 : 493 503.
23. Gold MR, Franks P, McCoy KI, Fryback DG. Toward consistency in cost-utility analyses: using national measures to create condition-specific values. Med Care 1998 36 : 778 792.
24. Guide to the Methods of Technology Appraisal (reference N0515). UK : National Institute for Clinical Excellence 2008. Available at: http://www.nice.org.uk.