Initial pattern of angiogenesis and bone formation following lateral ridge augmentation using rhPDGF and guided bone regeneration: An immunohistochemical study in dogs

Clinical Oral Implants Research

Volumn 21, Issue 1, 2010, Pages 90-99

  Schwarz, Frank ^a   Ferrari, Daniel ^a   Podolsky, Laura ^a   Mihatovic, Ilja ^a   Becker, Jürgen ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Animal experiments; Bone substitutes; Guided bone regeneration; Immunohistochemistry; RhPDGF

Indexed keywords

ALKALINE PHOSPHATASE; LACTATE DEHYDROGENASE; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR BB; PLATELET-DERIVED GROWTH FACTOR BB;

ANGIOGENESIS; ANIMAL; ARTICLE; BONE PROSTHESIS; BONE REGENERATION; DOG; DRUG EFFECT; ENZYME IMMUNOASSAY; MALE; METABOLISM; METHODOLOGY; NONPARAMETRIC TEST; ORAL SURGERY; RANDOMIZATION; TISSUE REGENERATION; TOOTH EXTRACTION;

ALKALINE PHOSPHATASE; ALVEOLAR RIDGE AUGMENTATION; ANIMALS; BONE REGENERATION; BONE SUBSTITUTES; DOGS; GUIDED TISSUE REGENERATION; IMMUNOENZYME TECHNIQUES; L-LACTATE DEHYDROGENASE; MALE; NEOVASCULARIZATION, PHYSIOLOGIC; PLATELET-DERIVED GROWTH FACTOR; RANDOM ALLOCATION; STATISTICS, NONPARAMETRIC; TOOTH EXTRACTION;

EID: 72949104122     PISSN: 09057161     EISSN: 16000501     Source Type: Journal    
DOI: 10.1111/j.1600-0501.2009.01845.x     Document Type: Article

References (29)

1. Araújo, M.G., Sonohara, M., Hayacibara, R., Cardaropoli, G. Lindhe, J. (2002) Lateral ridge augmentation by the use of grafts comprised of autologous bone or a biomaterial. An experiment in the dog. Journal of Clinical Periodontology 29 : 1122 1131.
2. Bateman, J., Intini, G., Margarone, J., Goodloe, S., Bush, P., Lynch, S.E. Dziak, R. (2005) Platelet-derived growth factor enhancement of two alloplastic bone matrices. Journal of Periodontology 76 : 1833 1841.
3. Becker, W., Lynch, S.E., Lekholm, U., Becker, B.E., Caffesse, R., Donath, K. Sanchez, R. (1992) A comparison of ePTFE membranes alone or in combination with platelet-derived growth factors and insulin-like growth factor-I or demineralized freeze-dried bone in promoting bone formation around immediate extraction socket implants. Journal of Periodontology 63 : 929 940.
4. Buemi, M., Galeano, M., Sturiale, A., Ientile, R., Crisafulli, C., Parisi, A., Catania, M., Calapai, G., Impala, P., Aloisi, C., Squadrito, F., Altavilla, D., Bitto, A., Tuccari, G. Frisina, N. (2004) Recombinant human erythropoietin stimulates angiogenesis and healing of ischemic skin wounds. Shock 22 : 169 173. (Pubitemid 40228196)
5. Canalis, E., McCarthy, T.L. Centrella, M. (1989) Effects of platelet-derived growth factor on bone formation in vitro. Journal of Cellular Physiology 140 : 530 537.
6. Chiapasco, M., Abati, S., Romeo, E. Vogel, C. (1999) Clinical outcome of autogenous bone blocks or guided bone regeneration with e-PTFE membranes for the reconstruction of narrow edentulous ridges. Clinical Oral Implants Research 10 : 278 288.
7. Donath, K. (1985) The diagnostic value of the new method for the study of undecalcified bones and teeth with attached soft tissue (äage-Schliff (sawing and grinding) technique). Pathology, Research and Practice 179 : 631 633.
8. Eyre-Brook, A.L. (1984) The periosteum: its function reassessed. Clinical Orthopaedics and Related Research 189 : 300 307.
9. Haroon, Z.A., Hettasch, J.M., Lai, T.S., Dewhirst, M.W. Greenberg, C.S. (1999) Tissue transglutaminase is expressed, active, and directly involved in rat dermal wound healing and angiogenesis. FASEB Journal 13 : 1787 1795.
10. Huja, S.S. Beck, F.M. (2007) Bone remodeling in maxilla, mandible, and femur of young dogs. Anatomical Record 291 : 1 5.
11. Jung, R.E., Glauser, R., Scharer, P., Hammerle, C.H., Sailer, H.F. Weber, F.E. (2003) Effect of rhBMP-2 on guided bone regeneration in humans. Clinical Oral Implants Research 14 : 556 568.
12. Jung, R.E., Thoma, D.S. Hammerle, C.H. (2008) Assessment of the potential of growth factors for localized alveolar ridge augmentation: a systematic review. Journal of Clinical Periodontology 35 : 255 281.
13. Lioubavina-Hack, N., Carmagnola, D., Lynch, S.E. Karring, T. (2005a) Effect of Bio-Oss with or without platelet-derived growth factor on bone formation by "guided tissue regeneration": a pilot study in rats. Journal of Clinical Periodontology 32 : 1254 1260.
14. Lioubavina-Hack, N., Karring, T., Lynch, S.E. Lindhe, J. (2005b) Methyl cellulose gel obstructed bone formation by GBR: an experimental study in rats. Journal of Clinical Periodontology 32 : 1247 1253.
15. Lynch, S.E., Buser, D., Hernandez, R.A., Weber, H.P., Stich, H., Fox, C.H. Williams, R.C. (1991) Effects of the platelet-derived growth factor/insulin-like growth factor-I combination on bone regeneration around titanium dental implants. Results of a pilot study in beagle dogs. Journal of Periodontology 62 : 710 716.
16. Mair, B., Fuerst, G., Kubitzky, P., Tangl, S., Bergmeister, H., Losert, U., Watzek, G. Gruber, R. (2007) The anti-angiogenic substance TNP-470 impairs peri-implant bone formation: a pilot study in the rabbit metaphysis model. Clinical Oral Implants Research 18 : 370 375.
17. Risau, W. (1997) Mechanisms of angiogenesis. Nature 386 : 671 674.
18. Rocchietta, I., Dellavia, C., Nevins, M. Simion, M. (2007) Bone regenerated via rhPDGF-bB and a deproteinized bovine bone matrix: backscattered electron microscopic element analysis. International Journal of Periodontics and Restorative Dentistry 27 : 539 545.
19. Schwarz, F., Ferrari, D., Mihatovic, I. Becker, J. (2009) Influence of recombinant human platelet derived growth factor on lateral ridge augmentation using a biphasic calcium phosphate and guided bone regeneration. A histomorphometrical study in dogs. Journal of Periodontology 80 : 1315 1323.
20. Schwarz, F., Rothamel, D., Herten, M., Ferrari, D., Sager, M. Becker, J. (2008b) Lateral ridge augmentation using particulated or block bone substitutes biocoated with rhGDF-5 and rhBMP-2: an immunohistochemical study in dogs. Clinical Oral Implants Research 19 : 642 652.
21. Schwarz, F., Rothamel, D., Herten, M., Sager, M. Becker, J. (2006) Angiogenesis pattern of native and cross-linked collagen membranes: an immunohistochemical study in the rat. Clinical Oral Implants Research 17 : 403 409.
22. Schwarz, F., Rothamel, D., Herten, M., Wustefeld, M., Sager, M., Ferrari, D. Becker, J. (2008a) Immunohistochemical characterization of guided bone regeneration at a dehiscence-type defect using different barrier membranes: an experimental study in dogs. Clinical Oral Implants Research 19 : 402 415.
23. Simion, M., Rocchietta, I. Dellavia, C. (2007) Three-dimensional ridge augmentation with xenograft and recombinant human platelet-derived growth factor-BB in humans: report of two cases. International Journal of Periodontics and Restorative Dentistry 27 : 109 115.
24. Simion, M., Rocchietta, I., Kim, D., Nevins, M. Fiorellini, J. (2006) Vertical ridge augmentation by means of deproteinized bovine bone block and recombinant human platelet-derived growth factor-BB: a histologic study in a dog model. International Journal of Periodontics and Restorative Dentistry 26 : 415 423.
25. Skawina, A. Gorczyca, W. (1984) The role of nutrient and periosteal blood vessels in the vascularization of the cortex of shafts of the long bones in human fetuses. Folia Morphologica 43 : 159 164.
26. Vikjaer, D., Blom, S., Hjorting-Hansen, E. Pinholt, E.M. (1997) Effect of platelet-derived growth factor-BB on bone formation in calvarial defects: an experimental study in rabbits. European Journal of Oral Sciences 105 : 59 66.
27. von Arx, T., Cochran, D.L., Hermann, J.S., Schenk, R.K. Buser, D. (2001a) Lateral ridge augmentation using different bone fillers and barrier membrane application. A histologic and histomorphometric pilot study in the canine mandible. Clinical Oral Implants Research 12 : 260 269.
28. von Arx, T., Cochran, D.L., Hermann, J.S., Schenk, R.K., Higginbottom, F.L. Buser, D. (2001b) Lateral ridge augmentation and implant placement: an experimental study evaluating implant osseointegration in different augmentation materials in the canine mandible. International Journal of Oral and Maxillofacial Implants 16 : 343 354. (Pubitemid 33673137)
29. Zhang, L., Leeman, E., Carnes, D.C. Graves, D.T. (1991) Human osteoblasts synthesize and respond to platelet-derived growth factor. American Journal of Physiology 261 : C348 C354.