메뉴 건너뛰기




Volumn 17, Issue 1, 2010, Pages 64-69

Placebo responses in randomized trials of antiepileptic drugs

Author keywords

Epilepsy; Meta analysis; Placebo effect

Indexed keywords

ANTICONVULSIVE AGENT; ESLICARBAZEPINE ACETATE; ETIRACETAM; HARKOSERIDE; LOSIGAMONE; PLACEBO; PREGABALIN; REMACEMIDE; RETIGABINE; TIAGABINE; TOPIRAMATE; VIGABATRIN; ZONISAMIDE;

EID: 72949099860     PISSN: 15255050     EISSN: 15255069     Source Type: Journal    
DOI: 10.1016/j.yebeh.2009.10.007     Document Type: Article
Times cited : (35)

References (42)
  • 1
    • 34447517730 scopus 로고    scopus 로고
    • A meta-analysis of the placebo response in complementary and alternative medicine trials of irritable bowel syndrome
    • Dorn S.D., Kaptchuk T.J., Park J.B., et al. A meta-analysis of the placebo response in complementary and alternative medicine trials of irritable bowel syndrome. Neurogastroenterol Motil 19 (2007) 630-637
    • (2007) Neurogastroenterol Motil , vol.19 , pp. 630-637
    • Dorn, S.D.1    Kaptchuk, T.J.2    Park, J.B.3
  • 2
    • 35748971487 scopus 로고    scopus 로고
    • Placebo response in the prophylaxis of migraine: a meta-analysis
    • Macedo A., Baños J.E., and Farré M. Placebo response in the prophylaxis of migraine: a meta-analysis. Eur J Pain 12 (2008) 68-75
    • (2008) Eur J Pain , vol.12 , pp. 68-75
    • Macedo, A.1    Baños, J.E.2    Farré, M.3
  • 3
    • 0034031172 scopus 로고    scopus 로고
    • Placebo effect in the acute treatment of migraine: subcutaneous placebos are better than oral placebos
    • De Craen A.J., Tijssen J.G., de Gans J., and Kleijnen J. Placebo effect in the acute treatment of migraine: subcutaneous placebos are better than oral placebos. J Neurol 247 (2000) 183-188
    • (2000) J Neurol , vol.247 , pp. 183-188
    • De Craen, A.J.1    Tijssen, J.G.2    de Gans, J.3    Kleijnen, J.4
  • 4
    • 0011984682 scopus 로고
    • Placebos and other biases in clinical trials in dementia
    • Canal N., et al. (Ed), Raven Press, New York
    • Korczyn A.D. Placebos and other biases in clinical trials in dementia. In: Canal N., et al. (Ed). Guidelines for drug trials in memory disorders (1993), Raven Press, New York 135-141
    • (1993) Guidelines for drug trials in memory disorders , pp. 135-141
    • Korczyn, A.D.1
  • 5
    • 0345707603 scopus 로고    scopus 로고
    • Meta-analysis of placebo rates in major depressive disorder trials
    • Stolk P., Ten Berg M.J., Hemels M.E., and Einarson T.R. Meta-analysis of placebo rates in major depressive disorder trials. Ann Pharmacother 37 (2003) 1891-1899
    • (2003) Ann Pharmacother , vol.37 , pp. 1891-1899
    • Stolk, P.1    Ten Berg, M.J.2    Hemels, M.E.3    Einarson, T.R.4
  • 7
    • 0035838997 scopus 로고    scopus 로고
    • Expectation and dopamine release: mechanism of the placebo effect in Parkinson's disease
    • De la Fuente-Fernandez R., Ruth T.J., Sossi V., et al. Expectation and dopamine release: mechanism of the placebo effect in Parkinson's disease. Science 293 (2001) 1164-1166
    • (2001) Science , vol.293 , pp. 1164-1166
    • De la Fuente-Fernandez, R.1    Ruth, T.J.2    Sossi, V.3
  • 9
    • 0342902205 scopus 로고    scopus 로고
    • Is the placebo powerless? An analysis of clinical trials comparing placebo with no treatment
    • Hróbjartsson A., and Gøtzsche P.C. Is the placebo powerless? An analysis of clinical trials comparing placebo with no treatment. N Engl J Med 344 (2001) 1594-1602
    • (2001) N Engl J Med , vol.344 , pp. 1594-1602
    • Hróbjartsson, A.1    Gøtzsche, P.C.2
  • 10
    • 0038823449 scopus 로고    scopus 로고
    • Magnitude of the placebo effect in randomized trials of antiepileptic agents
    • Burneo J.G., Montori V.M., and Faught E. Magnitude of the placebo effect in randomized trials of antiepileptic agents. Epilepsy Behav 3 (2002) 532-534
    • (2002) Epilepsy Behav , vol.3 , pp. 532-534
    • Burneo, J.G.1    Montori, V.M.2    Faught, E.3
  • 11
    • 50949123608 scopus 로고    scopus 로고
    • Greater response to placebo in children than in adults: a systematic review and meta-analysis in drug resistant partial epilepsy
    • Rheims S., Cucherat M., Arzimanoglou A., and Ryvlin P. Greater response to placebo in children than in adults: a systematic review and meta-analysis in drug resistant partial epilepsy. PLoS Med 5 (2008) 1223-1236
    • (2008) PLoS Med , vol.5 , pp. 1223-1236
    • Rheims, S.1    Cucherat, M.2    Arzimanoglou, A.3    Ryvlin, P.4
  • 12
    • 33645759446 scopus 로고    scopus 로고
    • Identifying baseline characteristics of placebo responders versus nonresponders in randomized double-blind trials of refractory partial-onset seizures
    • Niklson I., Edrich P., and Verdru P. Identifying baseline characteristics of placebo responders versus nonresponders in randomized double-blind trials of refractory partial-onset seizures. Epileptic Disord 8 (2006) 37-44
    • (2006) Epileptic Disord , vol.8 , pp. 37-44
    • Niklson, I.1    Edrich, P.2    Verdru, P.3
  • 13
    • 0033610734 scopus 로고    scopus 로고
    • Improving the quality of reports of meta-analyses of randomised controlled trials: the Quorom Statement
    • Moher D., Cook D.J., Eastwood S., et al. Improving the quality of reports of meta-analyses of randomised controlled trials: the Quorom Statement. Lancet 354 (1999) 1896-1900
    • (1999) Lancet , vol.354 , pp. 1896-1900
    • Moher, D.1    Cook, D.J.2    Eastwood, S.3
  • 14
    • 0030922816 scopus 로고    scopus 로고
    • Bias in meta-analysis detected by a simple, graphical test
    • Egger G.D., Schneider M., and Minder C. Bias in meta-analysis detected by a simple, graphical test. Br Med J 315 (1997) 629-634
    • (1997) Br Med J , vol.315 , pp. 629-634
    • Egger, G.D.1    Schneider, M.2    Minder, C.3
  • 15
    • 0028152471 scopus 로고
    • Systematic review: why sources of heterogeneity in meta-analysis should be investigated
    • Thompson S.G. Systematic review: why sources of heterogeneity in meta-analysis should be investigated. Br Med J 309 (1994) 1351-1355
    • (1994) Br Med J , vol.309 , pp. 1351-1355
    • Thompson, S.G.1
  • 16
    • 10544255353 scopus 로고    scopus 로고
    • Double-blind, placebo-controlled study of topiramate in patients with refractory partial epilepsy
    • Sharief M., Viteri C., Ben-Menachem E., et al. Double-blind, placebo-controlled study of topiramate in patients with refractory partial epilepsy. Epilepsy Res 25 (1996) 217-224
    • (1996) Epilepsy Res , vol.25 , pp. 217-224
    • Sharief, M.1    Viteri, C.2    Ben-Menachem, E.3
  • 17
    • 0029884747 scopus 로고    scopus 로고
    • Topiramate placebo-controlled dose-ranging trial in refractory partial epilepsy using 600-, 800-, and 1000-mg daily dosages
    • for the Topiramate YE Study Group
    • Privitera M., Fincham R., Penry J., et al., for the Topiramate YE Study Group. Topiramate placebo-controlled dose-ranging trial in refractory partial epilepsy using 600-, 800-, and 1000-mg daily dosages. Neurology 46 (1996) 1678-1683
    • (1996) Neurology , vol.46 , pp. 1678-1683
    • Privitera, M.1    Fincham, R.2    Penry, J.3
  • 18
    • 0029997934 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled study of vigabatrin three g/day in patients with uncontrolled complex partial seizures
    • for the Vigabatrin Protocol 024 Investigative Cohort
    • French J.A., Mosier M., Walker S., Sommerville K., Sussman N., and for the Vigabatrin Protocol 024 Investigative Cohort. A double-blind, placebo-controlled study of vigabatrin three g/day in patients with uncontrolled complex partial seizures. Neurology 46 (1996) 54-61
    • (1996) Neurology , vol.46 , pp. 54-61
    • French, J.A.1    Mosier, M.2    Walker, S.3    Sommerville, K.4    Sussman, N.5
  • 19
    • 0043181917 scopus 로고    scopus 로고
    • Double-blind, placebo-controlled trial of topiramate as add-on therapy in patients with refractory partial seizures
    • Ben-Menachem E., Henriksen O., Dam M., et al. Double-blind, placebo-controlled trial of topiramate as add-on therapy in patients with refractory partial seizures. Epilepsia 37 (1996) 539-543
    • (1996) Epilepsia , vol.37 , pp. 539-543
    • Ben-Menachem, E.1    Henriksen, O.2    Dam, M.3
  • 20
    • 0029922566 scopus 로고    scopus 로고
    • Topiramate placebo-controlled dose-ranging trial in refractory partial epilepsy using 200-, 400-, and 600-mg daily dosages
    • for the Topiramate YD Study Group
    • Faught E., Wilder B.J., Ramsay R.E., et al., for the Topiramate YD Study Group. Topiramate placebo-controlled dose-ranging trial in refractory partial epilepsy using 200-, 400-, and 600-mg daily dosages. Neurology 46 (1996) 1684-1690
    • (1996) Neurology , vol.46 , pp. 1684-1690
    • Faught, E.1    Wilder, B.J.2    Ramsay, R.E.3
  • 21
    • 9444251680 scopus 로고    scopus 로고
    • Double-blind, placebo-controlled trial of topiramate (600 mg daily) for the treatment of refractory partial epilepsy
    • Tassinari C.A., Michelucci R., Chauvel P., et al. Double-blind, placebo-controlled trial of topiramate (600 mg daily) for the treatment of refractory partial epilepsy. Epilepsia 37 (1996) 763-768
    • (1996) Epilepsia , vol.37 , pp. 763-768
    • Tassinari, C.A.1    Michelucci, R.2    Chauvel, P.3
  • 22
    • 0344878897 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled trial of tiagabine given three-times daily as add-on therapy for refractory partial seizures
    • for the Northern European Tiagabine Study Group
    • Kalviainen R., Brodie M.J., Duncan J., et al., for the Northern European Tiagabine Study Group. A double-blind, placebo-controlled trial of tiagabine given three-times daily as add-on therapy for refractory partial seizures. Epilepsy Res 30 (1998) 31-40
    • (1998) Epilepsy Res , vol.30 , pp. 31-40
    • Kalviainen, R.1    Brodie, M.J.2    Duncan, J.3
  • 23
    • 0032947717 scopus 로고    scopus 로고
    • Dose-response study of vigabatrin as add-on therapy in patients with uncontrolled complex partial seizures
    • Dean C., Mosier M., and Penry K. Dose-response study of vigabatrin as add-on therapy in patients with uncontrolled complex partial seizures. Epilepsia 40 (1999) 74-82
    • (1999) Epilepsia , vol.40 , pp. 74-82
    • Dean, C.1    Mosier, M.2    Penry, K.3
  • 24
    • 0033811027 scopus 로고    scopus 로고
    • Multicenter double-blind, randomized, placebo-controlled trial of levetiracetam as add-on therapy in patients with refractory partial seizures
    • for the European Levetiracetam Study Group
    • Shorvon S.D., Lowenthal A., Janz D., Bielen E., Loiseau P., and for the European Levetiracetam Study Group. Multicenter double-blind, randomized, placebo-controlled trial of levetiracetam as add-on therapy in patients with refractory partial seizures. Epilepsia 41 (2000) 1179-1186
    • (2000) Epilepsia , vol.41 , pp. 1179-1186
    • Shorvon, S.D.1    Lowenthal, A.2    Janz, D.3    Bielen, E.4    Loiseau, P.5
  • 25
    • 0033854805 scopus 로고    scopus 로고
    • Levetiracetam for partial seizures: results of a double-blind, randomized clinical trial
    • Cereghino J.J., Biton V., Abou-Khalil B., et al. Levetiracetam for partial seizures: results of a double-blind, randomized clinical trial. Neurology 55 (2000) 236-242
    • (2000) Neurology , vol.55 , pp. 236-242
    • Cereghino, J.J.1    Biton, V.2    Abou-Khalil, B.3
  • 26
    • 0034176841 scopus 로고    scopus 로고
    • Vigabatrin as add-on therapy for adult complex partial seizures: a double-blind, placebo-controlled multicentre study
    • for the Canadian Vigabatrin Study Group
    • Bruni J., Guberman A., Vachon L., Desforges C., and for the Canadian Vigabatrin Study Group. Vigabatrin as add-on therapy for adult complex partial seizures: a double-blind, placebo-controlled multicentre study. Seizure 9 (2000) 224-232
    • (2000) Seizure , vol.9 , pp. 224-232
    • Bruni, J.1    Guberman, A.2    Vachon, L.3    Desforges, C.4
  • 27
    • 0033811661 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled study of topiramate in adult patients with refractory partial epilepsy
    • Yen D.J., Yu H.Y., Guo Y.C., et al. A double-blind, placebo-controlled study of topiramate in adult patients with refractory partial epilepsy. Epilepsia 41 (2000) 1162-1166
    • (2000) Epilepsia , vol.41 , pp. 1162-1166
    • Yen, D.J.1    Yu, H.Y.2    Guo, Y.C.3
  • 28
    • 0035960602 scopus 로고    scopus 로고
    • Randomized controlled trial of zonisamide for the treatment of refractory partial-onset seizures
    • for the Zonisamide 922 Trial Group
    • Faught E., Ayala R., Montouris G.G., Leppik I.E., and for the Zonisamide 922 Trial Group. Randomized controlled trial of zonisamide for the treatment of refractory partial-onset seizures. Neurology 57 (2001) 1774-1779
    • (2001) Neurology , vol.57 , pp. 1774-1779
    • Faught, E.1    Ayala, R.2    Montouris, G.G.3    Leppik, I.E.4
  • 29
    • 0035050624 scopus 로고    scopus 로고
    • Losigamone add-on therapy in partial epilepsy: a placebo-controlled study
    • for the Losigamone Study Group
    • Bauer J., Dienel A., Elger C.E., and for the Losigamone Study Group. Losigamone add-on therapy in partial epilepsy: a placebo-controlled study. Acta Neurol Scand 103 (2001) 226-230
    • (2001) Acta Neurol Scand , vol.103 , pp. 226-230
    • Bauer, J.1    Dienel, A.2    Elger, C.E.3
  • 30
    • 0036785082 scopus 로고    scopus 로고
    • Low-dose topiramate in adults with treatment-resistant partial-onset seizures
    • for the EPAJ-119 Study Group
    • Guberman A., Neto W., Gassmann-Mayer C., and for the EPAJ-119 Study Group. Low-dose topiramate in adults with treatment-resistant partial-onset seizures. Acta Neurol Scand 106 (2002) 183-189
    • (2002) Acta Neurol Scand , vol.106 , pp. 183-189
    • Guberman, A.1    Neto, W.2    Gassmann-Mayer, C.3
  • 31
    • 0036265066 scopus 로고    scopus 로고
    • Remacemide hydrochloride as an add-on therapy in epilepsy: a randomized, placebo-controlled trial of three dose levels (300, 600 and 1200 mg/day) in a Q.I.D. regimen
    • Chadwick D.W., Betts T.A., Boddie H.G., et al. Remacemide hydrochloride as an add-on therapy in epilepsy: a randomized, placebo-controlled trial of three dose levels (300, 600 and 1200 mg/day) in a Q.I.D. regimen. Seizure 11 (2002) 114-123
    • (2002) Seizure , vol.11 , pp. 114-123
    • Chadwick, D.W.1    Betts, T.A.2    Boddie, H.G.3
  • 32
    • 0036258904 scopus 로고    scopus 로고
    • Remacemide hydrochloride as an add-on therapy in epilepsy: a randomized, placebo-controlled trial of three dose levels (300, 600 and 800 mg/day) in a B.I.D. regimen
    • Jones M.W., Blume W.T., Guberman A., et al. Remacemide hydrochloride as an add-on therapy in epilepsy: a randomized, placebo-controlled trial of three dose levels (300, 600 and 800 mg/day) in a B.I.D. regimen. Seizure 11 (2002) 104-113
    • (2002) Seizure , vol.11 , pp. 104-113
    • Jones, M.W.1    Blume, W.T.2    Guberman, A.3
  • 33
    • 0042827363 scopus 로고    scopus 로고
    • Efficacy and safety of losigamone in partial seizures: a randomized double-blind study
    • for the Losigamone Study Group
    • Baulac M., Klement S., and for the Losigamone Study Group. Efficacy and safety of losigamone in partial seizures: a randomized double-blind study. Epilepsy Res 55 (2003) 177-189
    • (2003) Epilepsy Res , vol.55 , pp. 177-189
    • Baulac, M.1    Klement, S.2
  • 34
    • 0347985301 scopus 로고    scopus 로고
    • Pregabalin add-on treatment: a randomized, double-blind, placebo-controlled, dose-response study in adults with partial seizures
    • Arroyo S., Anhut H., Kugler A.R., Lee C.M., et al. Pregabalin add-on treatment: a randomized, double-blind, placebo-controlled, dose-response study in adults with partial seizures. Epilepsia 45 (2004) 20-27
    • (2004) Epilepsia , vol.45 , pp. 20-27
    • Arroyo, S.1    Anhut, H.2    Kugler, A.R.3    Lee, C.M.4
  • 35
    • 3042636758 scopus 로고    scopus 로고
    • Randomized, controlled clinical trial of zonisamide as adjunctive treatment for refractory partial seizures
    • Sackellares J.C., Ramsay R.E., Wilder B.J., Browne III T.R., and Shellenberger M.K. Randomized, controlled clinical trial of zonisamide as adjunctive treatment for refractory partial seizures. Epilepsia 45 (2004) 610-617
    • (2004) Epilepsia , vol.45 , pp. 610-617
    • Sackellares, J.C.1    Ramsay, R.E.2    Wilder, B.J.3    Browne III, T.R.4    Shellenberger, M.K.5
  • 36
    • 13144306049 scopus 로고    scopus 로고
    • Dose-dependent safety and efficacy of zonisamide: a randomized, double-blind, placebo-controlled study in patients with refractory partial seizures
    • Brodie M.J., Duncan R., Vespignani H., et al. Dose-dependent safety and efficacy of zonisamide: a randomized, double-blind, placebo-controlled study in patients with refractory partial seizures. Epilepsia 46 (2005) 31-41
    • (2005) Epilepsia , vol.46 , pp. 31-41
    • Brodie, M.J.1    Duncan, R.2    Vespignani, H.3
  • 37
    • 27744434295 scopus 로고    scopus 로고
    • Pregabalin add-on treatment in patients with partial seizures: a novel evaluation of flexible-dose and fixed-dose treatment in a double-blind, placebo-controlled study
    • Elger C.E., Brodie M.J., Anhut H., Lee C.M., and Barrett J.A. Pregabalin add-on treatment in patients with partial seizures: a novel evaluation of flexible-dose and fixed-dose treatment in a double-blind, placebo-controlled study. Epilepsia 46 (2005) 1926-1936
    • (2005) Epilepsia , vol.46 , pp. 1926-1936
    • Elger, C.E.1    Brodie, M.J.2    Anhut, H.3    Lee, C.M.4    Barrett, J.A.5
  • 38
    • 13244277459 scopus 로고    scopus 로고
    • Safety and efficacy of two pregabalin regimens for add-on treatment of partial epilepsy
    • Beydoun A., Uthman B.M., Kugler A.R., et al. Safety and efficacy of two pregabalin regimens for add-on treatment of partial epilepsy. Neurology 64 (2005) 475-480
    • (2005) Neurology , vol.64 , pp. 475-480
    • Beydoun, A.1    Uthman, B.M.2    Kugler, A.R.3
  • 39
    • 33645019934 scopus 로고    scopus 로고
    • Efficacy and safety of levetiracetam (up to 2000 mg/day) in Taiwanese patients with refractory partial seizures: a multicenter, randomized, double-blind, placebo-controlled study
    • Tsai J.J., Yen D.J., Hsih M.S., et al. Efficacy and safety of levetiracetam (up to 2000 mg/day) in Taiwanese patients with refractory partial seizures: a multicenter, randomized, double-blind, placebo-controlled study. Epilepsia 47 (2006) 72-81
    • (2006) Epilepsia , vol.47 , pp. 72-81
    • Tsai, J.J.1    Yen, D.J.2    Hsih, M.S.3
  • 40
    • 34447344551 scopus 로고    scopus 로고
    • Efficacy and safety of oral lacosamide as adjunctive therapy in adults with partial-onset seizures
    • Ben-Menachem E., Biton V., Jatuzis D., et al. Efficacy and safety of oral lacosamide as adjunctive therapy in adults with partial-onset seizures. Epilepsia 48 (2007) 1308-1317
    • (2007) Epilepsia , vol.48 , pp. 1308-1317
    • Ben-Menachem, E.1    Biton, V.2    Jatuzis, D.3
  • 41
    • 34247252905 scopus 로고    scopus 로고
    • Randomized, multicenter, dose-ranging trial of retigabine for partial-onset seizures
    • for the 205 Study Group
    • Porter R.J., Partiot A., Sachdeo R., Nohria V., Alves W.M., and for the 205 Study Group. Randomized, multicenter, dose-ranging trial of retigabine for partial-onset seizures. Neurology 68 (2007) 1197-1204
    • (2007) Neurology , vol.68 , pp. 1197-1204
    • Porter, R.J.1    Partiot, A.2    Sachdeo, R.3    Nohria, V.4    Alves, W.M.5
  • 42
    • 33847611166 scopus 로고    scopus 로고
    • Eslicarbazepine acetate: a double-blind, add-on, placebo-controlled exploratory trial in adult patients with partial-onset seizures
    • Elger C., Bialer M., Cramer J.A., et al. Eslicarbazepine acetate: a double-blind, add-on, placebo-controlled exploratory trial in adult patients with partial-onset seizures. Epilepsia 48 (2007) 497-504
    • (2007) Epilepsia , vol.48 , pp. 497-504
    • Elger, C.1    Bialer, M.2    Cramer, J.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.