Expression of metallothionein-1 (MT-1) mRNA in the rat testes and liver after cadmium injectionet al.

Systems Biology in Reproductive Medicine

Volumn 55, Issue 5-6, 2009, Pages 188-192

  Bhattacharyya, Asok K ^e   Mukhopadhyay, Dyutiman ^a   Mitra, Amrita ^a   Nandi, Parag ^a   Varghese, Alex C ^b   Murmu, Nabendu ^c   Chowdhury, Rajdeep ^d   Chaudhuri, Keya ^d  

^a UNIVERSITY OF CALCUTTA   (India)

^b AMRI HOSPITALS   (India)

^c CHITTARANJAN NATIONAL CANCER INSTITUTE   (India)

^d INDIAN INSTITUTE OF CHEMICAL BIOLOGY   (India)

^e NONE

Author keywords

Cadmium; Liver; Metallothionein; mRNA; Testes

Indexed keywords

BETA ACTIN; CADMIUM; MESSENGER RNA; METALLOTHIONEIN I; METALLOTHIONEIN II;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOSYNTHESIS; CONTROLLED STUDY; DENSITOMETRY; DETOXIFICATION; ENVIRONMENTAL EXPOSURE; LIVER; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REPRODUCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ANALYSIS; RNA ISOLATION; TESTIS;

ANIMALS; CADMIUM; LIVER; MALE; METALLOTHIONEIN; RATS; RATS, WISTAR; RNA, MESSENGER; TESTIS;

EID: 72949094845     PISSN: 19396368     EISSN: 19396368     Source Type: Journal    
DOI: 10.3109/19396360903114429     Document Type: Article

References (17)

1. Abel, J., de Ruiter, N. and Kühn-Velten, W. N. (1991) Comparative study on metallothionein induction in whole testicular tissue and isolated Leydig cells. Arch Toxicol 65:228-234.
2. Bhave, M. R., Wilson, M. J. and Waalkes, M. P. (1988) Methylation status and organization of the metallothionein-I gene in livers and testes of strains of mice resistant and susceptible to cadmium. Toxicology 50:231-245.
3. Coogan, T. P., Shiraishi, N. and Waalkes, M. P. (1995) Minimal basal activity and lack of metal-induced activation of the metallothionein gene correlates with lobe-specific sensitivity to the carcinogenic effects of cadmium in the rat prostate. Toxicol Appl Pharmacol 132:164-173.
4. De Celis, R., Pedrón-Nuevo, N. and Feria-Velasco, A. (1996) Toxicology of male reproduction in animals and humans. Arch Androl 37:201-218.
5. Lee, K. F., Lau, K. M. and Ho, S. M. (1999) Effects of cadmium on metallothionein-I and metallothionein-II mRNA expression in rat ventral, lateral, and dorsal prostatic lobes: Quantification by competitive RT-PCR. Toxicol Appl Pharmacol 154:20-27.
6. McKenna, I. M., Bare, R. M. and Waalkes, M. P. (1996) Metallothionein gene expression in testicular interstitial cells and liver of rats treated with cadmium. Toxicology 107:121-130.
7. Ren, X. Y., Zhou, Y., Zhang, J. P., Feng, W. H. and Jiao, B. H. (2003) Expression of metallothionein gene at different time in testicular interstitial cells and liver of rats treated with cadmium. World J Gastroenterol 9:1554-1558. (Pubitemid 36992353)
8. Samarawickrama, G. P. (1979) Biological effects of cadmium in mammals. In: The chemistry, biochemistry and biology of cadmium, Webb, M. (Ed.), Amsterdam: Elsevier/North-Holland; pp. 341-421.
9. Shiraishi, N., Barter, R. A., Uno, H. and Waalkes, M. P. (1993a) Effect of progesterone pretreatment on cadmium toxicity in the male Fischer (F344/NCr) rat. Toxicol Appl Pharmacol 118:113-118. (Pubitemid 23069443)
10. Shiraishi, N., Uno, H. and Waalkes, M. P. (1993b) Effect of L-ascorbic acid pretreatment on cadmium toxicity in the male Fischer (F344/NCr) rat. Toxicology 85:85-100.
11. Shiraishi, N. and Waalkes, M. P. (1994) Enhancement of metallothionein gene expression in male Wistar (WF/NCr) rats by treatment with calmodulin inhibitors: Potential role of calcium regulatory pathways in metallothionein induction. Toxicol Appl Pharmacol 125:97-103.
12. Suzuki, J. S., Kodama, N., Molotkov, A., Aoki, E. and Tohyama, C. (1998) Isolation and identifcation metallothionein isoforms (MT-1 and MT-2) in the rat testis. Biochem J 334:695-701.
13. Tohyama, C., Suzuki, J. S., Homma, S. T., Nishimura, N. and Nishimura, H. (1993) Regulation of metallothionein biosynthesis in genital organs of male rats. In: Metallothionein III, Suzuki, K. T., Imura, N. and Kimura, M. (Eds.), Basel: Birkhauser Verlag; pp. 443-456.
14. Vasconcelos, M. H., Tam, S. C., Beattie, J. H. and Hesketh, J. E. (1996) Evidence for differences in the post-transcriptional regulation of rat metallothionein isoforms. Biochem J 315:665-671.
15. Vasconcelos, M. H., Tam, S. C., Hesketh, J. E., Reid, M. and Beattie, J. H. (2002) Metal-and tissue-dependent relationship between metallothionein mRNA and protein. Toxicol Appl Pharmacol 182:91-97.
16. Waalkes, M. P. and Rehm, S. (1992) Carcinogenicity of oral cadmium in the male wistar (WF/NCr) rat: Effect of chronic dietary zinc deficiency. Toxicol Sci 19:512-520.
17. Zhou, T., Zhou, G., Song, W., Eguchi, N., Lu, W., Lundin, E., Jin, T. and Nordberg, G. (1999) Cadmium-induced apoptosis and changes in expression of p53, c-jun and MT-I genes in testes and ventral prostate of rats. Toxicology 142:1-13.