Definitive evidence that a single N-glycan among three glycans on inducible costimulator is required for proper protein trafficking and ligand binding

Biochemical and Biophysical Research Communications

Volumn 391, Issue 1, 2010, Pages 557-563

  Kamei, Naoki ^a   Fukui, Rie ^a   Suzuki, Yoshiyuki ^a   Kajihara, Yasuhiro ^b   Kinoshita, Mitsuhiro ^c   Kakehi, Kazuaki ^c   Hojo, Hironobu ^d   Tezuka, Katsunari ^a,e   Tsuji, Takashi ^a,f  

^a TOKYO UNIVERSITY OF SCIENCE   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c KINKI UNIVERSITY   (Japan)

^d TOKAI UNIVERSITY   (Japan)

^e OTSUKA CHEMICAL CO LTD   (Japan)

^f Organ Technologies Inc   (Japan)

Author keywords

Costimulatory molecule; Inducible costimulator (ICOS); N Glycosylation; Protein quality control; Protein trafficking

Indexed keywords

AMINO ACID; ASPARAGINE; CELL PROTEIN; GLYCAN; GLYCAN DERIVATIVE; GLYCOPROTEIN; INDUCIBLE COSTIMULATOR PROTEIN; MUTANT PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CELL MEMBRANE; CELL MIGRATION; CELL SURFACE; CONTROLLED STUDY; GLYCOSYLATION; HUMAN; HUMAN CELL; LIGAND BINDING; MOLECULE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN MODIFICATION; PROTEIN STABILITY; PROTEIN STRUCTURE; T LYMPHOCYTE;

ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; GLYCOSYLATION; HUMANS; JURKAT CELLS; MUTATION; POLYSACCHARIDES; PROTEIN FOLDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN TRANSPORT;

EID: 72949093993     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.11.098     Document Type: Article

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