E-cadherin/β-catenin and CD10: A limited immunohistochemical panel to distinguish pancreatic endocrine neoplasm from solid pseudopapillary neoplasm of the pancreas on endoscopic ultrasound-guided fine-needle aspirates of the pancreas

American Journal of Clinical Pathology

Volumn 132, Issue 6, 2009, Pages 831-839

  Burford, Holly ^a   Baloch, Zubair ^b   Liu, Xiuli ^c   Jhala, Darshana ^a   Siegal, Gene P ^a   Jhala, Nirag ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c LERNER RESEARCH INSTITUTE   (United States)

Author keywords

catenin; CD10; E cadherin; Endoscopic ultrasound guidance; Fine needle aspiration; Pancreatic endocrine neoplasms; Solid pseudopapillary pancreatic neoplasms

Indexed keywords

ALPHA 1 ANTITRYPSIN; BETA CATENIN; CD56 ANTIGEN; CHROMOGRANIN A; COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGEN; PROGESTERONE RECEPTOR; SYNAPTOPHYSIN; UVOMORULIN; VIMENTIN;

ARTICLE; ASPIRATION BIOPSY; DIFFERENTIAL DIAGNOSIS; ENDOSCOPIC ECHOGRAPHY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; IMMUNOREACTIVITY; PANCREAS ISLET CELL TUMOR; PANCREAS TUMOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; SOLID PSEUDOPAPILLARY PANCREATIC TUMOR;

ADULT; BETA CATENIN; BIOPSY, FINE-NEEDLE; CADHERINS; CARCINOMA, PAPILLARY; DIAGNOSIS, DIFFERENTIAL; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; MALE; MIDDLE AGED; NEPRILYSIN; PANCREATIC NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 72949091858     PISSN: 00029173     EISSN: None     Source Type: Journal    
DOI: 10.1309/AJCPVT8FCLFDTZWI     Document Type: Article

References (34)

1. Adams AL, Siegal GP, Jhala NC. Solid pseudopapillary tumor of the pancreas: a review of salient clinical and pathologic features. Adv Anat Pathol. 2008;15:39-45.
2. Canzonieri V, Berretta M, Buonadonna A, et al. Solid pseudopapillary tumour of the pancreas. Lancet Oncol. 2003;4:255-256.
3. Klimstra DS, Wenig BM, Heffess CS. Solid-pseudopapillary tumor of the pancreas: a typically cystic carcinoma of low malignant potential. Semin Diagn Pathol. 2000;17:66-80.
4. Klimstra DS. Nonductal neoplasms of the pancreas. Mod Pathol. 2007;20(suppl 1):S94-S112.
5. Dong DJ, Zhang SZ. Solid-pseudopapillary tumor of the pancreas: CT and MRI features of 3 cases. Hepatobiliary Pancreat Dis Int. 2006;5:300-304.
6. Machado MC, Machado MA, Bacchella T, et al. Solid pseudopapillary neoplasm of the pancreas: distinct patterns of onset, diagnosis, and prognosis for male versus female patients. Surgery. 2008;143:29-34.
7. Bhanot P, Nealon WH, Walser EM, et al. Clinical, imaging, and cytopathological features of solid pseudopapillary tumor of the pancreas: a clinicopathologic study of three cases and review of the literature. Diagn Cytopathol. 2005;33:421-428.
8. Labate AM, Klimstra DL, Zakowski MF. Comparative cytologic features of pancreatic acinar cell carcinoma and islet cell tumor. Diagn Cytopathol. 1997;16:112-116.
9. Stelow EB, Bardales RH, Stanley MW. Pitfalls in endoscopic ultrasound-guided fine-needle aspiration and how to avoid them. Adv Anat Pathol. 2005;12:62-73.
10. Jhala NC, Jhala DN, Chhieng DC, et al. Endoscopic ultrasound-guided fine-needle aspiration: a cytopathologist's perspective. Am J Clin Pathol. 2003;120:351-367.
11. Pitman MB, Deshpande V. Endoscopic ultrasound-guided fine needle aspiration cytology of the pancreas: a morphological and multimodal approach to the diagnosis of solid and cystic mass lesions. Cytopathology. 2007;18:331-347.
12. Bardales RH, Centeno B, Mallery JS, et al. Endoscopic ultrasound-guided fine-needle aspiration cytology diagnosis of solid-pseudopapillary tumor of the pancreas: a rare neoplasm of elusive origin but characteristic cytomorphologic features. Am J Clin Pathol. 2004;121:654-662.
13. Pettinato G, Di Vizio D, Manivel JC, et al. Solid-pseudopapillary tumor of the pancreas: a neoplasm with distinct and highly characteristic cytological features. Diagn Cytopathol. 2002;27:325-334.
14. Jhala D, Eloubeidi M, Chhieng DC, et al. Fine needle aspiration biopsy of the islet cell tumor of pancreas: a comparison between computerized axial tomography and endoscopic ultrasound-guided fine needle aspiration biopsy. Ann Diagn Pathol. 2002;6:106-112.
15. Gu M, Ghafari S, Lin F, et al. Cytological diagnosis of endocrine tumors of the pancreas by endoscopic ultrasound-guided fine-needle aspiration biopsy. Diagn Cytopathol. 2005;32:204-210.
16. Stelow EB, Bardales RH, Shami VM, et al. Cytology of pancreatic acinar cell carcinoma. Diagn Cytopathol. 2006;34:367-372.
17. Liu X, Rauch TM, Siegal GP, et al. Solid-pseudopapillary neoplasm of the pancreas: three cases with a literature review. Appl Immunohistochem Mol Morphol. 2006;14:445-453.
18. Tanaka Y, Kato K, Notohara K, et al. Frequent beta-catenin mutation and cytoplasmic/nuclear accumulation in pancreatic solid-pseudopapillary neoplasm. Cancer Res. 2001;61:8401-8404.
19. Tang WW, Stelter AA, French S, et al. Loss of cell-adhesion molecule complexes in solid pseudopapillary tumor of pancreas. Mod Pathol. 2007;20:509-513.
20. Matsunou H, Konishi F. Papillary-cystic neoplasm of the pancreas. A clinicopathologic study concerning the tumor aging and malignancy of nine cases. Cancer. 1990;65:283-291.
21. Aydiner F, Erinanc H, Savas B, et al. Solid pseudopapillary tumor of the pancreas: emphasis on differential diagnosis from aggressive tumors of the pancreas. Turk J Gastroenterol. 2006;17:219-222.
22. Lai HW, Su CH, Li AF, et al. Malignant solid and pseudopapillary tumor of the pancreas: clinicohistological, immunohistochemical, and flow cytometric evaluation. Hepatogastroenterology. 2006;53:291-295.
23. Notohara K, Hamazaki S, Tsukayama C, et al. Solid-pseudopapillary tumor of the pancreas: immunohistochemical localization of neuroendocrine markers and CD10. Am J Surg Pathol. 2000;24:1361-1371.
24. Audard V, Cavard C, Richa H, et al. Impaired E-cadherin expression and glutamine synthetase overexpression in solid pseudopapillary neoplasm of the pancreas. Pancreas. 2008;36:80-83.
25. Pelosi G, Iannucci A, Zamboni G, et al. Solid and cystic papillary neoplasm of the pancreas: a clinico-cytopathologic and immunocytochemical study of five new cases diagnosed by fine-needle aspiration cytology and a review of the literature. Diagn Cytopathol. 1995;13:233-246.
26. Jhala N, Siegal GP, Jhala D. Fine-needle aspiration: a powerful modality in the preoperative diagnosis of solid pseudopapillary neoplasm of the pancreas. Pathol Case Rev. 2007;12:170-176.
27. Jhala N, Siegal GP, Jhala D. Large, clear cytoplasmic vacuolation: an under-recognized cytologic clue to distinguish solid pseudopapillary neoplasm of the pancreas from pancreatic endocrine neoplasm on fine-needle aspiration. Cancer. 2008;114:249-254.
28. Serra S, Salahshor S, Fagih M, et al. Nuclear expression of E-cadherin in solid pseudopapillary tumors of the pancreas. JOP. 2007;8:296-303.
29. El-Bahrawy MA, Rowan A, Horncastle D, et al. E-cadherin/catenin complex status in solid pseudopapillary tumor of the pancreas. Am J Surg Pathol. 2008;32:1-7.
30. Kim MJ, Jang SJ, Yu E. Loss of E-cadherin and cytoplasmic-nuclear expression of beta-catenin are the most useful immunoprofiles in the diagnosis of solid-pseudopapillary neoplasm of the pancreas. Hum Pathol. 2008;39:251-258.
31. Chetty R, Serra S. Membrane loss and aberrant nuclear localization of E-cadherin are consistent features of solid pseudopapillary tumour of the pancreas: an immunohistochemical study using two antibodies recognizing different domains of the E-cadherin molecule. Histopathology. 2008;52:325-330.
32. Audard V, Cavard C, Richa H, et al. Impaired E-cadherin expression and glutamine synthetase overexpression in solid pseudopapillary neoplasm of the pancreas. Pancreas. 2008;36:80-83.
33. Farinola MA, Weir EG, Ali SZ. CD56 expression of neuroendocrine neoplasms on immunophenotyping by flow cytometry: a novel diagnostic approach to fine-needle aspiration biopsy. Cancer. 2003;99:240-246.
34. Leon ME, Hou JS, Galindo LM, et al. Fine-needle aspiration of adult small-round-cell tumors studied with flow cytometry. Diagn Cytopathol. 2004;31:147-154.