Endoscopic Ultrasound-Guided Fine-Needle Aspiration Cytology Diagnosis of Solid-Pseudopapillary Tumor of the Pancreas: A Rare Neoplasm of Elusive Origin but Characteristic Cytomorphologic Features

American Journal of Clinical Pathology

Volumn 121, Issue 5, 2004, Pages 654-662

  Bardales, Ricardo H ^a   Centeno, Barbara ^c   Mallery, J Shawn ^a   Lai, Rebecca ^a   Pochapin, Mark ^b   Guiter, Gerardo ^b   Stanley, Michael W ^a  

^a HENNEPIN COUNTY MEDICAL CENTER   (United States)

^b WEILL CORNELL MEDICAL CENTER   (United States)

^c H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

Author keywords

Cystic; Cytology; Endoscopic; Needle aspiration; Neoplasm; Pancreas; Pseudopapillary; Solid; Ultrasound

Indexed keywords

ALPHA 1 ANTICHYMOTRYPSIN; ALPHA 1 ANTITRYPSIN; CHROMOGRANIN; CYTOKERATIN; NEURON SPECIFIC ENOLASE; SYNAPTOPHYSIN; VIMENTIN;

ADULT; ASPIRATION CYTOLOGY; CANCER CYTODIAGNOSIS; CLINICAL ARTICLE; CYTOLOGY; DIFFERENTIAL DIAGNOSIS; ENDOCRINE TUMOR; ENDOSCOPIC BIOPSY; ENDOSCOPY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; PANCREAS PSEUDOCYST; PANCREAS RESECTION; PANCREAS TUMOR; PREOPERATIVE EVALUATION; PRIORITY JOURNAL; REVIEW; SOLID TUMOR; TUMOR DIAGNOSIS; TUMOR VOLUME; ULTRASOUND;

EID: 2042452463     PISSN: 00029173     EISSN: None     Source Type: Journal    
DOI: 10.1309/DKK2B9V4N0W26A8Q     Document Type: Review

References (72)

1. Klimstra DS, Wenig BM, Heffess CS. Solid-pseudopapillary tumor of the pancreas: a typically cystic carcinoma of low malignant potential. Semin Diagn Pathol. 2000;17:66-80.
2. Adsay NV, Klimstra DS. Cystic forms of typically solid pancreatic tumors. Semin Diagn Pathol. 2000;17:81-88.
3. Solcia E, Capella C, Kloppel G. Tumors of the exocrine pancreas. In: Tumors of the Pancreas. Washington, DC: Armed Forces Institute of Pathology; 1997:31-144. Atlas of Tumor Pathology; Third series, Fascicle 20.
4. Solcia E, Capella C, Kloppel G. Tumors of the exocrine pancreas. In: Tumors of the Pancreas. Washington, DC: Armed Forces Institute of Pathology; 1997:31-144. Atlas of Tumor Pathology; Third series, Fascicle 20.
5. Frantz VK. Tumors of the pancreas. In: Anonymous Atlas of Tumor Pathology. Washington, DC: Armed Forces Institute of Pathology; 1959:32-33. Section 7, Fascicles 27-28.
6. Washington K. Solid-pseudopapillary tumor of the pancreas: challenges presented by an unusual pancreatic neoplasm [editorial]. Ann Surg Oncol. 2002;9:3-4.
7. Martin RC, Klimstra DS, Brennan MF, et al. Solid-pseudopapillary tumor of the pancreas: a surgical enigma? Ann Surg Oncol. 2002;9:35-40.
8. Koito K, Namieno T, Nagakawa T, et al. Solitary cystic tumor of the pancreas: EUS-pathologic correlation. Gastrointest Endosc. 1997;45:268-276.
9. Brugge WR. Role of endoscopic ultrasound in the diagnosis of cystic lesions of the pancreas. Pancreatology. 2001;1:637-640.
10. Das DK, Bhambhani S, Kumar N, et al. Ultrasound guided percutaneous fine needle aspiration cytology of pancreas: a review of 61 cases. Trop Gastroenterol. 1995;16:101-109.
11. Nadler EP, Novikov A, Landzberg BR, et al. The use of endoscopic ultrasound in the diagnosis of solid pseudopapillary tumors of the pancreas in children. J Pediatr Surg. 2002;37:1370-1373.
12. Centeno BA. Fine needle aspiration biopsy of the pancreas. Clin Lab Med. 1998;18:401-427, v-vi.
13. Collins BT, Saeed ZA. Fine needle aspiration biopsy of pancreatic endocrine neoplasms by endoscopic ultrasonographic guidance. Acta Cytol. 2001;45:905-907.
14. Rampy BA, Waxman I, Xiao SY, et al. Serous cystadenoma of the pancreas with papillary features: a diagnostic pitfall on fine-needle aspiration biopsy. Arch Pathol Lab Med. 2001;125:1591-1594.
15. Kloppel G, Maurer R, Hofmann E, et al. Solid-cystic (papillary-cystic) tumours within and outside the pancreas in men: report of two patients. Virchows Arch A Pathol Anat Histopathol. 1991;418:179-183.
16. Rebhandl W, Felberbauer FX, Puig S, et al. Solid-pseudopapillary tumor of the pancreas (Frantz tumor) in children: report of four cases and review of the literature. J Surg Oncol. 2001;76:289-296.
17. Ryley NG, Baigrie CF, Buley ID. Papillary and solid neoplasm of the pancreas: fine needle aspiration cytology. Cytopathology. 1994;5:310-315.
18. Snajdauf J, Pycha K, Rygl M, et al. Papillary cystic and solid tumor of the pancreas: surgical therapy with the use of CUSA, and a review of the pediatric literature. Eur J Pediatr Surg. 1999;9:416-419.
19. Cervantes-Monteil F, Florez-Zorrilla C, Alvarez-Martinez I. Solid-cystic pseudopapillary tumor of the pancreas: acute post-traumatic presentation; case report and review of the literature [in Spanish]. Rev Gastroenterol Mex. 2002;67:93-96.
20. Orlando CA, Bowman RL, Loose JH. Multicentric papillary-cystic neoplasm of the pancreas. Arch Pathol Lab Med. 1991;115:958-960.
21. Fukunaga M. Pseudopapillary solid cystic tumor arising from an extrapancreatic site. Arch Pathol Lab Med. 2001;125:1368-1371.
22. Mao C, Guvendi M, Domenico DR, et al. Papillary cystic and solid tumors of the pancreas: a pancreatic embryonic tumor? studies of three cases and cumulative review of the world's literature. Surgery. 1995;118:821-828.
23. Gonzalez-Campora R, Rios Martin JJ, Villar Rodriguez JL, et al. Papillary cystic neoplasm of the pancreas with liver metastasis coexisting with thyroid papillary carcinoma. Arch Pathol Lab Med. 1995;119:268-273.
24. Jaksic T, Yaman M, Thomer P, et al. A 20-year review of pediatric pancreatic tumors. J Pediatr Surg. 1992;27:1315-1317.
25. Lam KY, Lo CY, Fan ST. Pancreatic solid-cystic-papillary tumor: clinicopathologic features in eight patients from Hong Kong and review of the literature. World J Surg. 1999;23:1045-1050.
26. Hachiya M, Hachiya Y, Mitsui K, et al. Solid, cystic and vanishing tumors of the pancreas. Clin Imaging. 2003;27:106-108.
27. Cappellari JO, Geisinger KR, Albertson DA, et al. Malignant papillary cystic tumor of the pancreas. Cancer. 1990;66:193-198.
28. Pettinato G, Manivel JC, Ravetto C, et al. Papillary cystic tumor of the pancreas: a clinicopathologic study of 20 cases with cytologic, immunohistochemical, ultrastructural, and flow cytometric observations, and a review of the literature [published correction appears in Am J Clin Pathol. 1993;99:764]. Am J Clin Pathol. 1992;98:478-488.
29. Pettinato G, Manivel JC, Ravetto C, et al. Papillary cystic tumor of the pancreas: a clinicopathologic study of 20 cases with cytologic, immunohistochemical, ultrastructural, and flow cytometric observations, and a review of the literature [published correction appears in Am J Clin Pathol. 1993;99:764]. Am J Clin Pathol. 1992;98:478-488.
30. Kamei K, Funabiki T, Ochiai M, et al. Three cases of solid and cystic tumor of the pancreas: analysis comparing the histopathological findings and DNA histograms. Int J Pancreatol. 1991;10:269-278.
31. Cho NH, Go JH, Jung SH, et al. Correlation between proliferating index and prognostic factors in papillary cystic tumors of the pancreas. J Korean Med Sci. 1995;10:342-351.
32. Grant LD, Lauwers GY, Meloni AM, et al. Unbalanced chromosomal translocation, der(17)t(13;17)(q14;p11) in a solid and cystic papillary epithelial neoplasm of the pancreas. Am J Surg Pathol. 1996;20:339-345.
33. Matsubara K, Nigami H, Harigaya H, et al. Chromosome abnormality in solid and cystic tumor of the pancreas. Am J Gastroenterol. 1997;92:1219-1221.
34. Tanaka Y, Kato K, Notohara K, et al. Frequent beta-catenin mutation and cytoplasmic/nuclear accumulation in pancreatic solid-pseudopapillary neoplasm. Cancer Res. 2001;61:8401-8404.
35. Miao J, Kusafuka T, Kuroda S, et al. Mutation of beta-catenin and its protein accumulation in solid and cystic tumor of the pancreas associated with metastasis. Int J Mol Med. 2003;11:461-464.
36. Tanaka Y, Notohara K, Kato K, et al. Usefulness of beta-catenin immunostaining for the differential diagnosis of solid-pseudopapillary neoplasm of the pancreas. Am J Surg Pathol. 2002;26:818-820.
37. Abraham SC, Wu TT, Klimstra DS. Distinctive molecular genetic alterations in sporadic and familial adenomatous polyposis-associated pancreatoblastomas: frequent alterations in the APC/beta-catenin pathway and chromosome 11p. Am J Pathol. 2002;159:1619-1627.
38. Oh YL, Song SY, Ahn G. Expression of maspin in pancreatic neoplasms: application of maspin immunohistochemistry to the differential diagnosis. Appl Immunohistochem Molecul Morphol. 2002;10:62-66.
39. Wilson MB, Adams DB, Garen PD, et al. Aspiration cytologic, ultrastructural, and DNA cytometric findings of solid and papillary tumor of the pancreas. Cancer. 1992;69:2235-2243.
40. Skarda JS, Honick AB, Gibbins CS, et al. Papillary-cystic tumor of the pancreas in a young woman: fine-needle aspiration cytology, ultrastructure and DNA analysis. Diagn Cytopathol. 1994;10:20-24.
41. Balercia G, Zamboni G, Bogina G, et al. Solid-cystic tumor of the pancreas: an extensive ultrastructural study of fourteen cases. J Submicrosc Cytol Pathol. 1995;27:331-340.
42. Ferlan-Marolt V, Pleskovic L, Pegan V. Solid papillary-cystic tumor of the pancreas. Hepatogastroenterology. 1999;46:2978-2982.
43. Yamaue H, Tanimura H, Shono Y, et al. Solid and cystic tumor of the pancreas: clinicopathologic and genetic studies of four cases. Int J Pancreatol. 2000;27:69-76.
44. Kissane JM. Pancreatoblastoma and solid and cystic papillary tumor: two tumors related to pancreatic ontogeny. Semin Diagn Pathol. 1994;11:152-164.
45. Kosmahl M, Seada LS, Janig U, et al. Solid-pseudopapillary tumor of the pancreas: its origin revisited. Virchows Arch. 2000;436:473-480.
46. Yeh TS, Jan YY, Chiu CT, et al. Characterisation of oestrogen receptor, progesterone receptor, trefoil factor 1, and epidermal growth factor and its receptor in pancreatic cystic neoplasms and pancreatic ductal adenocarcinoma. Gut. 2002;51:712-716.
47. Remadi S, Mac Gee W, Doussis-Anagnostopoulou I, et al. Papillary-cystic tumor of the pancreas. Diagn Cytopathol. 1996;15:398-402.
48. Buetow PC, Parrino TV, Buck JL, et al. Islet cell tumors of the pancreas: pathologic-imaging correlation among size, necrosis and cysts, calcification, malignant behavior, and functional status. AJR Am J Roentgenol. 1995;165:1175-1179.
49. Furukawa H, Takayasu K, Mukai K, et al. Ductal adenocarcinoma of the pancreas associated with intratumoral calcification. Int J Pancreatol. 1995;17:291-296.
50. Uchimi K, Fujita N, Noda Y, et al. Solid cystic tumor of the pancreas: report of six cases and a review of the Japanese literature. J Gastroenterol. 2002;37:972-980.
51. Pettinato G, Di Vizio D, Manivel JC, et al. Solid-pseudopapillary tumor of the pancreas: a neoplasm with distinct and highly characteristic cytological features. Diagn Cytopathol. 2002;27:325-334.
52. Kashima K, Hayashida Y, Yokoyama S, et al. Cytologic features of solid and cystic tumor of the pancreas. Acta Cytol. 1997;41:443-449.
53. Katz LB, Ehya H. Aspiration cytology of papillary cystic neoplasm of the pancreas. Am J Clin Pathol. 1990;94:328-333.
54. Pelosi G, Iannucci A, Zamboni G, et al. Solid and cystic papillary neoplasm of the pancreas: a clinico-cytopathologic and immunocytochemical study of five new cases diagnosed by fine-needle aspiration cytology and a review of the literature. Diagn Cytopathol. 1995;13:233-246.
55. Chen KT, Workman RD, Efird TA, et al. Fine needle aspiration cytology diagnosis of papillary tumor of the pancreas. Acta Cytol. 1986;30:523-527.
56. Foote A, Simpson JS, Stewart RJ, et al. Diagnosis of the rare solid and papillary epithelial neoplasm of the pancreas by fine needle aspiration cytology: light and electron microscopic study of a case. Acta Cytol. 1986;30:519-522.
57. Granter SR, DiNisco S, Granados R. Cytologic diagnosis of papillary cystic neoplasm of the pancreas. Diagn Cytopathol. 1995;12:313-319.
58. Jayaram G, Chaturvedi KU, Jindal RK, et al. Papillary cystic neoplasm of the pancreas: report of a case diagnosed by fine needle aspiration cytology. Acta Cytol. 1990;34:429-433.
59. Mandrekar SR, Pinto RG, Patil R, et al. Solid and papillary epithelial neoplasm of the pancreas: report of a case with diagnosis by fine needle aspiration cytology. Acta Cytol. 1997;41:1823-1827.
60. Mendonca ME, Bivar-Weinholtz J, Soares J. Fine needle aspiration cytology of a solid and papillary epithelial neoplasm of the pancreas. Acta Cytol. 1991;35:258-260.
61. Naresh KN, Borges AM, Chinoy RF, et al. Solid and papillary epithelial neoplasm of the pancreas: diagnosis by fine needle aspiration cytology in four cases. Acta Cytol. 1995;39:489-493.
62. Stachura J, Popiela T, Pietron M, et al. Cytology of solid and papillary epithelial neoplasms of the pancreas: a case report. Diagn Cytopathol. 1988;4:339-341.
63. Sneige N, Ordonez NG, Veanattukalathil S, et al. Fine-needle aspiration cytology in pancreatic endocrine tumors. Diagn Cytopathol. 1987;3:35-40.
64. Lam KY, Lo CY. Pancreatic endocrine tumour: a 22-year clinico-pathological experience with morphological, immunohistochemical observation and a review of the literature. Eur J Surg Oncol. 1997;23:36-42.
65. Nguyen GK, Rayani NA. Hyperplastic and neoplastic endocrine cells of the pancreas in aspiration biopsy. Diagn Cytopathol. 1986;2:204-211.
66. Notohara K, Hamazaki S, Tsukayama C, et al. Solid-pseudopapillary tumor of the pancreas: immunohistochemical localization of neuroendocrine markers and CD10. Am J Surg Pathol. 2000;24:1361-1371.
67. Kitajima T, Tomioka T, Tajima Y, et al. Small non-functioning endocrine tumor of pancreas: comparison with solid cystic tumor. J Gastroenterol. 1998;33:129-133.
68. Schwartz RW, Munfakh NA, Zweng TN, et al. Nonfunctioning cystic neuroendocrine neoplasms of the pancreas. Surgery. 1994;115:645-649.
69. Samuel LH, Frierson HF Jr. Fine needle aspiration cytology of acinar cell carcinoma of the pancreas: a report of two cases. Acta Cytol. 1996;40:585-591.
70. Villanueva RR, Nguyen-Ho P, Nguyen GK. Needle aspiration cytology of acinar-cell carcinoma of the pancreas: report of a case with diagnostic pitfalls and unusual ultrastructural findings. Diagn Cytopathol. 1994;10:362-364.
71. Hara H, Suda K, Oyama T. Cytologic study of noninvasive intraductal papillary-mucinous carcinoma of the pancreas. Acta Cytol. 2002;43:519-526.
72. Stelow EB, Stanley MW, Bardales RH, et al. Intraductal papillary-mucinous neoplasm of the pancreas: the findings and limitations of cytologic samples obtained by endoscopic ultrasound-guided fine-needle aspiration. Am J Clin Pathol. 2003;120:398-404.