Selection of suitable operating conditions to minimize the gradient equilibration time in the separation of drugs by Ultra-High-Pressure Liquid Chromatography with volatile (mass spectrometry-compatible) buffers

Journal of Chromatography A

Volumn 1217, Issue 4, 2010, Pages 459-472

  Grivel, Candice ^a   Rocca, Jean Louis ^a   Guillarme, Davy ^b   Veuthey, Jean Luc ^b   Heinisch, Sabine ^a  

^a UNIVERSITÉ DE LYON   (France)

^b UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

Equilibration time; Gradient elution; HTLC; Pharmaceuticals; UHPLC; Volatile buffers

Indexed keywords

ANALYSIS TIME; BENEFICIAL EFFECTS; CURRENT TRENDS; DETECTION LIMITS; EQUILIBRATION PROCESS; EQUILIBRATION TIME; GRADIENT TIME; HIGH TEMPERATURE; IONIZABLE COMPOUNDS; MOBILE PHASE; OPERATING CONDITION; OPERATING PARAMETERS; PH ADJUSTMENT; REVERSED PHASE; RUN TO RUN; STATIONARY PHASE; ULTRA-HIGH-PRESSURE LIQUID CHROMATOGRAPHY; ULTRAHIGH PRESSURE;

CHROMATOGRAPHIC ANALYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; SEPARATION; THERMAL EFFECTS;

HIGH PRESSURE LIQUID CHROMATOGRAPHY;

ACETONITRILE; ACETYLSALICYLIC ACID; ATENOLOL; BUFFER; CAFFEINE; CLOZAPINE; DIPHENHYDRAMINE; ETHYL PARABEN; IMIPRAMINE; METHYL PARABEN; N,N DIMETHYLANILINE; NADOLOL; PHENOL; PINDOLOL; PROCAINE; PROPRANOLOL; PROTRIPTYLINE; URACIL;

ANALYTIC METHOD; ANALYTICAL PARAMETERS; ARTICLE; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG STRUCTURE; ELUTION; FLOW RATE; GRADIENT EQUILIBRATION TIME; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL; REPRODUCIBILITY; SEPARATION TECHNIQUE; TEMPERATURE;

ACETONITRILES; BUFFERS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; MASS SPECTROMETRY; PHARMACEUTICAL PREPARATIONS; REPRODUCIBILITY OF RESULTS; TEMPERATURE; TIME FACTORS; VOLATILIZATION;

EID: 72949089333     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2009.11.059     Document Type: Article

References (27)

1. Mazzeo J.R., Neue U.D., Kele M., and Plumb R.S. Anal. Chem. 77 (2005) 460A
2. Nguyen D.T.-T., Guillarme D., Rudaz S., and Veuthey J.-L. J. Sep. Sci. 29 (2006) 1836
3. Thompson J.D., and Carr P.W. Anal. Chem. 74 (2002) 4150
4. Cabooter D., Heinisch S., Rocca J.L., Clicq D., and Desmet G. J. Chromatogr. A 1143 (2007) 121
5. Plumb R., Mazzeo J.R., Grumbach E.S., Rainville P., Jones M., Wheat T., Neue U.D., Smith B., and Johnson K.A. J. Sep. Sci. 30 (2007) 1158
6. Lestremau A., de Villiers F., Linen A., Cooper R., Szucs P., and Sandra P. J. Chromatogr. A 1138 (2007) 120
7. Nguyen D.T.-T., Guillarme D., Heinisch S., Barrioulet M.P., Rocca J.-L., Rudaz S., and Veuthey J.L. J. Chromatogr. A 1167 (2007) 76
8. Xiang Y., Liu Y., and Lee M.L. J. Chromatogr. A 1104 (2006) 198
9. Heinisch S., Desmet G., Clicq D., and Rocca J.-L. J. Chromatogr. A 1203 (2008) 124
10. Neue U.D., and Mazzeo J.R. J. Sep. Sci. 24 (2001) 921
11. Heinisch S., and Rocca J.L. J. Chromatogr. A 1216 (2009) 642
12. Dolan J.W. LC-GC 21 (2003) 968
13. Cole L.A., and Dorsey J.G. Anal. Chem. 62 (1990) 16
14. Patthy M. J. Chromatogr. A 592 (1992) 143
15. Marchand D.H., Williams L.A., Dolan J.W., and Snyder L.R. J. Chromatogr. A 1015 (2003) 53
16. Coym J.W., and Roe B.W. J. Chromatogr. A 1154 (2007) 182
17. Pappa-Louisi A., Nikitas P., and Agrafiotou P. J. Chromatogr. A 1127 (2006) 97
18. Schellinger A.P., Stoll D.R., and Carr P.W. J. Chromatogr. A 1064 (2005) 143
19. Schellinger A.P., Stoll D.R., and Carr P.W. J. Chromatogr. A 1192 (2008) 41
20. Schellinger A.P., Stoll D.R., and Carr P.W. J. Chromatogr. A 1192 (2008) 54
21. Kirkland J.J. J. Chromatogr. A 1060 (2004) 9
22. Przybyciel M., and Majors R.E. LC-GC 20 (2002) 516
23. Majors R.E. LC-GC 18 (2000) 262
24. Majors R.E. LC-GC North Am. 20 (2002) 516
25. Walter T.H., Iraneta P., and Caparella M. J. Chromatogr. A 1075 (2005) 177
26. Scott R.P.W., and Simpson C.F. J. Chromatogr. 197 (1980) 11
27. Gilroy J., Dolan J.W., and Snyder L.R. J. Chromatogr. A 1000 (2003) 757