Low air levels of benzene: Correlation between biomarkers of exposure and genotoxic effects

Toxicology Letters

Volumn 192, Issue 1, 2010, Pages 22-28

  Fracasso, Maria Enrica ^a   Doria, Denise ^a   Bartolucci, Giovanni Battista ^b   Carrieri, Mariella ^b   Lovreglio, Piero ^c   Ballini, Andrea ^c   Soleo, Leonardo ^c   Tranfo, Giovanna ^d   Manno, Maurizio ^e  

^a UNIVERSITY OF VERONA   (Italy)

^b UNIVERSITY OF PADOVA   (Italy)

^c UNIVERSITY OF BARI   (Italy)

^d ISPESL   (Italy)

^e UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Benzene exposure; Chromosomal aberrations; Comet assay; GSH; S PMA; t,t, MA

Indexed keywords

BENZENE; BIOLOGICAL MARKER; GLUTATHIONE; MUCONIC ACID; PHENYLMERCAPTURIC ACID; UNCLASSIFIED DRUG;

ADULT; AIR SAMPLER; ARTICLE; BIOLOGICAL MONITORING; CHEMICAL CARCINOGENESIS; CHROMOSOME ABERRATION; COMET ASSAY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DNA DAMAGE; GAS CHROMATOGRAPHY; GENOTOXICITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; MALE; MASS SPECTROMETRY; OCCUPATIONAL EXPOSURE; OCCUPATIONAL TOXICOLOGY; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; SMOKING HABIT; URINALYSIS; URINARY EXCRETION;

ACETYLCYSTEINE; ADULT; AIR POLLUTANTS, OCCUPATIONAL; BENZENE; BIOLOGICAL MARKERS; CHROMOSOME ABERRATIONS; COMET ASSAY; DNA DAMAGE; GLUTATHIONE PEROXIDASE; HUMANS; INDUSTRY; MALE; MIDDLE AGED; MUTAGENICITY TESTS; OCCUPATIONAL EXPOSURE; PETROLEUM; SORBIC ACID; STATISTICS, NONPARAMETRIC;

EID: 72949085766     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2009.04.028     Document Type: Article

References (38)

1. Andreoli C., Leopardi P., and Crebelli R. Detection of DNA damage in human lymphocytes by alkaline single cell gel electrophoresis after exposure to benzene or benzene metabolites. Mutat. Res. 377 (1997) 95-104
2. Anwar W.A. Monitoring of human populations at risk by different cytogenetic end points. Environ. Health Perspect. 102 Suppl. 4 (1994) 131-134
3. Aprea C., Sciarra G., Bozzi N., Pagliantini M., Perico A., Bavazzano P., Leandri A., Carrieri M., Scapellato M.L., Bettinelli M., and Bartolucci G.B. Reference values of urinary trans,trans-muconic acid: Italian Multicentric Study. Arch. Environ. Contam. Toxicol. 55 (2008) 329-340
4. Barch M.J., Knutsen T., and Spurbeck J.L. The AGT Cytogenetics Laboratory Manual. 3rd ed. (1997), Lippincott-Raven, Philadelphia, PA
5. 2) not a Gaussian distribution. Mutat. Res. 398 (1998) 101-110
6. Baumgartner A., Schmid T.E., Cemeli E., and Anderson D. Parallel evaluation of doxorubicin-induced genetic damage in human lymphocytes and sperm using the comet assay and spectral karyotyping. Mutagenesis 19 4 (2004) 313-318
7. Bender M.A., Preston R.J., Leonard R.C., Pyatt B.E., Gooch P.C., and Shelby M.D. Chromosomal aberration and sister-chromatid exchange frequencies in peripheral blood lymphocytes of a large human population sample. Mutat. Res. 204 (1988) 421-433
8. Bonassi S., Abbondandolo A., Camurri L., Dal Pra L., De Ferrari M., Degrassi F., Forni A., Lamberti L., Lando C., Padovani P., Sbrana I., Vecchio D., and Puntoni R. Are chromosome aberrations in circulating lymphocytes predictive of future cancer onset in humans? Preliminary results of an Italian cohort study. Cancer Genet. Cytogenet. 79 (1995) 133-135
9. Breen A.P., and Murphy J.A. Reaction of oxyl radicals with DNA. Free Radic. Biol. Med. 18 (1995) 1033-1077
10. Bruckner J.V., and Warren D.A. Toxic effects of solvents and vapors. In: Klaassen C.D. (Ed). Casarett & Doull's Toxicology The Basic Science of Poisons (2001), McGraw-Hill, USA
11. Carere A., Antoccia A., Crebelli R., Degrassi F., Fiore M., Iavarone I., Isacchi G., Lagorio S., Leopardi P., Marcon F., Palitti F., Tanzarella C., and Zijno A. Genetic effects of petroleum fuels: cytogenetic monitoring of gasoline station attendants. Mutat. Res. 332 (1995) 17-26
12. Carrer P., Maroni M., Alcini D., Cavallo D., Fustinoni S., Lovato L., and Visigalli F. Assessment through environmental and biological measurements of total daily exposure to volatile organic compounds of office workers in Milan. Indoor Air 10 (2000) 258-268
13. Carrieri M., Bonfiglio E., Scapellato Ml., Macca' I., Tranfo G., Faranda P., Paci E., and Bartolucci G.B. Comparison of exposure assessment methods in occupational exposure to benzene in gasoline filling-station attendants. Toxicol. Lett. 162 (2006) 146-152
14. Cereser C., Guichard J., Drai J., Bannier E., Garcia I., Boget S., Parvaz P., and Revol A. Quantitation of reduced and total glutathione at the femtomole level by high-performance liquid chromatography with fluorescence detection: application to red blood cells and cultured fibroblasts. J. Chromatogr. B: Biomed. Sci. Appl. 752 (2001) 123-132
15. Choi Y., Shin D., Park S., Chung Y., and Kim M. Biological monitoring of benzene in residents living near petrochemical industrial areas in Korea. J. Occup. Health 42 (2000) 31-37
16. Collins R.A., Duthie S.J., and Dobson V.L. Direct enzymatic detection of endogenous oxidative base damage in human lymphocyte DNA. Carcinogenesis 14 (1993) 1733-1735
17. De Jong G., van Sittert N.J., and Natarajan A.T. Cytogenetic monitoring of industrial populations potentially exposed to genotoxic chemicals and of control populations. Mutat. Res. 204 (1988) 451-464
18. De Marini D.M. Genotoxicity of tobacco smoke and tobacco smoke condensate: a review. Mutat. Res. 567 (2004) 447-474
19. Duarte-Davidson R., Courage C., Rushton L., and Levy L. Benzene in the environment: an assessment of the potential risks to the health of the population. Occup. Environ. Med. 58 (2001) 2-13
20. Fairbairn D.W., Olive P.L., and O'Neill K.L. The comet assay: a comprehensive review. Mutat. Res. 464 (1995) 229-237
21. Fracasso M.E., Perbellini L., Solda S., Talamini G., and Franceschetti P. Lead induced DNA strand breaks in lymphocytes of exposed workers: role of reactive oxygen species and protein kinase C. Mutat. Res. 515 (2002) 159-169
22. Fracasso M.E., Doria D., Franceschetti P., Perbellini L., and Romeo L. DNA damage and repair capacity by comet assay in lymphocytes of white-collar active smokers and passive smokers (non- and ex-smokers) at workplace. Toxicol. Lett. 167 (2006) 131-141
23. Hagmar L., Bonassi S., Stromberg U., Brǿgger A., Knudsen L.E., Norppa H., and Reuterwall C. Chromosomal aberrations in lymphocytes predict human cancer: a report from the European Study Group on Cytogenetic Biomarkers and Health (ESCH). Cancer Res. 58 (1998) 4117-4121
24. Melikian A.A., Qu Q., Shore R., Li G., Li H., Jin X., Cohen B., Chen L., Li Y., Yin S., Mu R., Zhang X., and Wang Y. Personal exposure to different levels of benzene and its relationships to the urinary metabolites S-phenylmercapturic acid and trans,trans-muconic acid. J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. 778 (2002) 211-221
25. Mohankumar M.N., Janani S., Karthikeya P.B., Vivek P.R., and Jeevanram R.K. DNA damage and integrity of UV-induced DNA repair in lymphocytes of smokers analysed by the comet assay. Mutat. Res. 520 (2002) 179-187
26. Muscat J.E., Kleinman W., Colosimo S., Muir A., Lazarus P., Park J., and Richie Jr. J.P. Enhanced protein glutathiolation and oxidative stress in cigarette smokers. Free Radic. Biol. Med. 36 (2004) 464-470
27. NIOSH. Hydrocarbons, aromatic: method 1501. NIOSH Manual of Analytical Methods. 4th rev. ed. (2003), U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHHS (NIOSH), Cincinnati, OH
28. Olive P.L., Wlodek D., Durand R.E., and Banath J.P. Factors influencing DNA migration from individual cells subjected to gel electrophoresis. Exp. Cell Res. 198 (1992) 259-267
29. Parker D.V. Personal reflection on 59 years of study of benzene toxicology. Environ. Health Perspect. 104 (1996) 1123-1128
30. Rajaee-Behbahani N., Schmezer P., Risch A., Rittgen W., Kayser K.W., Dienemann H., Schulz V., Drings P., and Thiel S. Altered DNA repair capacity and bleomycin sensitivity as risk markers for non-small cell lung cancer. Int. J. Cancer 95 (2001) 86-91
31. Ross D. The role of metabolism and specific metabolites in benzene-induced toxicity: evidence and issues. J. Toxicol. Environ. Health 61 (2000) 357-372
32. Singh N.P., McCoy M.T., Tice R.R., and Schneider E.L. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp. Cell Res. 175 (1988) 184-191
33. Snyder R., Lee E.W., Kocsis J.J., and Witmer C.M. Bone marrow depressant and leukemogenic actions of benzene. Life Sci. 21 (1977) 1709-1721
34. Speit G., Witton-Davies T., Heepchantree W., Trenz K., and Hoffmann H. Investigations on the effect of cigarette smoking in the comet assay. Mutat. Res. 542 (2003) 33-42
35. Villani P., Altavista P.L., Castaldi L., Leter G., and Cordelli E. Analysis of DNA oxidative damage related to cell proliferation. Mutat. Res. 464 (2000) 229-237
36. Whysner J., Reddy M.V., Ross P.M., Mohan M., and Lax E.A. Genotoxicity of benzene and its metabolites. Mutat. Res. 566 (2004) 99-130
37. Wojewòdzka M., Kruszewski T., Iwanenko A.R., and Collins I. Lack of adverse effect of smoking habit on DNA strand breakage and base damage, as revealed by the alkaline comet assay. Mutat. Res. 440 (1999) 19-25
38. Zhang L., Eastmond D.A., and Smith M.T. The nature of chromosomal aberrations detected in humans exposed to benzene. Crit. Rev. Toxicol. 32 (2002) 1-42