In vivo veritas: The power of in situ manipulation of cells in a living animal. Focus on "Expression of plasmid DNA in the salivary gland epithelium: Novel approaches to study dynamic cellular processes in live animals"

American Journal of Physiology - Cell Physiology

Volumn 297, Issue 6, 2009, Pages

  Baum, Bruce J ^a  

^a NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MEMBRANE PROTEIN; PLASMID DNA; DNA;

ACINAR CELL; CELL CULTURE; CELL FUNCTION; CELL MANIPULATION; CELL SELECTION; CELL TYPE; EDITORIAL; EPITHELIUM; EXOCRINE GLAND; GENE EXPRESSION; GENE THERAPY; GENE TRANSFER; GENETIC MANIPULATION; GENETIC TRANSFECTION; IN VITRO STUDY; IN VIVO STUDY; MEMBRANE TRANSPORT; NONHUMAN; PRIORITY JOURNAL; SALIVARY GLAND; ANIMAL; METABOLISM; METHODOLOGY; NOTE; PHYSIOLOGY; PLASMID;

ANIMALIA;

ANIMALS; CELL PHYSIOLOGICAL PHENOMENA; DNA; EPITHELIUM; PHYSIOLOGY; PLASMIDS; SALIVARY GLANDS;

EID: 72949084280     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00437.2009     Document Type: Editorial

References (17)

1. Adriaansen J, Perez P, Goldsmith CM, Zheng C, Baum BJ. Differential sorting of human parathyroid hormone after transduction of mouse and rat salivary glands. Hum Gene Ther 19: 1021-1028, 2008.
2. Baum BJ, Voutetakis A, Wang J. Salivary glands: novel target sites for gene therapeutics. Trends Mol Med 10: 585-590, 2004.
3. Castle JD. Protein secretion by rat parotid acinar cells. Pathways and regulation. Ann NY Acad Sci 842: 115-124, 1998.
4. Dunn KW, Sandoval RM, Kelly KJ, Dagher PC, Tanner GA, Atkinson SJ, Bacallao RL, Molitoris BA. Functional studies of the kidney of living animals using multicolor two-photon microscopy. Am J Physiol Cell Physiol 283: C905-C916, 2002.
5. Gorr SU, Venkatesh SG, Darling DS. Parotid secretory granules: crossroads of secretory pathways and protein storage. J Dent Res 84: 500-509, 2005.
6. Isenman L, Liebow C, Rothman S. The endocrine secretion of mammalian digestive enzymes by exocrine glands. Am J Physiol Endocrinol Metab 276: E223-E232, 1999.
7. Ishii M, Egen JG, Klaushen F, Meir-Schellersheim M, Saeki Y, Vacher J, Proia RL, Germain RN. Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis. Nature 458: 524-528, 2009.
8. Kleinfeld D, Mitra PP, Helmchen F, Denk W. Fluctuations and stimulus-induced changes in blood flow observed in individual capillaries in layers 2 through 4 of rat neocortex. Proc Natl Acad Sci USA 95: 15741-15746, 1998.
9. Leonora J, Tieche JM, Celestin J. Physiological factors affecting secretion of parotid hormone. Am J Physiol Endocrinol Metab 252: E477-E484, 1987.
10. Masters BR, So PT, Gratton E. Multiphoton excitation fluorescence microscopy and spectroscopy of in vivo human skin. Biophys J 72: 2405-2412, 1997.
11. Mazo IB, Gutierrez-Ramos JC, Frenette PS, Hynes RO, Wagner DD, von Andrian UH. Hematopoietic progenitor cell rolling in bone marrow microvessels: parallel contributions by endothelial selectins and vascular cell adhesion molecule 1. J Exp Med 188: 465-474, 1998.
12. Rothstein EC, Nauman M, Chesnick S, Balaban RS. Multiphoton excitation microscopy in intact animals. J Microsc 222: 58-64, 2006.
13. Sramkova M, Masedunskas A, Parente L, Molinolo A, Weigert R. Expression of plasmid DNA in the salivary gland epithelium: novel approaches to study dynamic cellular processes in live animals. Am J Physiol Cell Physiol. First published September 30, 2009; doi:10.1152/ajpcell.00262.2009.
14. Sumen C, Mempel TR, Mazo IB, von Andrian UH. Intravital microscopy: visualizing immunity in context. Immunity 21: 315-329, 2004.
15. Svoboda K, Tank DW, Denk W. Direct measurement of coupling between dendritic spines and shafts. Science 272: 716-719, 1996.
16. Worbs T, Mempel TR, Bolter J, von Andrian UH, Forster R. CCR7 ligands stimulate the intranodal motility of T lymphocytes in vivo. J Exp Med 204: 489-495, 2007.
17. Voutetakis A, Zheng C, Metzger M, Cotrim AP, Donahue RE, Dunbar CE, Baum BJ. Sorting of transgenic secretory proteins in rhesus macaque parotid glands after adenovirus-mediated gene transfer. Hum Gene Ther 19: 1401-1405, 2008.