Brucine-derived amino alcohol catalyzed asymmetric Henry reaction: An orthogonal enantioselectivity approach

Organic Letters

Volumn 11, Issue 24, 2009, Pages 5682-5685

  Kim, Hun Young ^a   Oh, Kyungsoo ^a  

^a INDIANA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 72849133517     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol902380z     Document Type: Article

References (61)

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52. 2 (0% ee).
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58. 21-OH group protected), significantly lower ee's were observed (0% ee and 23% ee).
59. 2OH (72% ee), PhOH (70% ee).
60. 2 resulted in 11% ee while 20 mol % of 1, ethylene glycol, or ethanolamine gave products with 40-50% ee.
61. Employment of 1-nitropropane gave results similar to those of nitroethane, but the chiral HPLC separations for these products are not fully resolved using AS-H, AD-H, and OD-H columns. Our full account for these cases will be reported elsewhere.