High frequencies of virus-specific CD8+ T-cell precursors

Journal of Virology

Volumn 83, Issue 24, 2009, Pages 12907-12916

  Seedhom, Mina O ^a   Jellison, Evan R ^a,b   Daniels, Keith A ^a   Welsh, Raymond M ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P14; UNCLASSIFIED DRUG; VIRUS GLYCOPROTEIN; VIRUS GLYCOPROTEIN GP33;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD8+ T LYMPHOCYTE; CELL EXPANSION; CELL PROLIFERATION; CELL SPECIFICITY; CELL TRANSFER; CONTROLLED STUDY; DILUTION; GENE FREQUENCY; IMMUNE RESPONSE; IN VIVO STUDY; LIMITING DILUTION ASSAY; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MEMORY T LYMPHOCYTE; MOUSE; NONHUMAN; PRE T LYMPHOCYTE; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; TRANSGENICS; VACCINIA VIRUS; VIRUS; VIRUS MENINGITIS;

ADOPTIVE TRANSFER; ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; CELL MOVEMENT; IMMUNOLOGIC MEMORY; IMMUNOPHENOTYPING; LYMPHOCYTIC CHORIOMENINGITIS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MICE; MICE, INBRED C57BL; PRECURSOR CELLS, T-LYMPHOID; VACCINIA; VACCINIA VIRUS;

LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MUS; VACCINIA VIRUS;

EID: 72849110582     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.01722-09     Document Type: Article

References (39)

1. Baum, P. D., and J. M. McCune. 2006. Direct measurement of T-cell receptor repertoire diversity with AmpliCot. Nat. Methods 3:895-901.
2. Blattman, J. N., R. Antia, D. J. Sourdive, X. Wang, S. M. Kaech, K. Murali-Krishna, J. D. Altman, and R. Ahmed. 2002. Estimating the precursor frequency of naive antigen-specific CD8 T cells. J. Exp. Med. 195:657-664.
3. Bliss, C. 1934. The method of probits. Science 79:38-39.
4. Bousso, P., A. Casrouge, J. D. Altman, M. Haury, J. Kanellopoulos, J. P. Abastado, and P. Kourilsky. 1998. Individual variations in the murine T cell response to a specific peptide reflect variability in naive repertoires. Immunity 9:169-178. (Pubitemid 28400030)
5. Casrouge, A., E. Beaudoing, S. Dalle, C. Pannetier, J. Kanellopoulos, and P. Kourilsky. 2000. Size estimate of the alpha beta TCR repertoire of naive mouse splenocytes. J. Immunol. 164:5782-5787. (Pubitemid 30389821)
6. Cose, S., C. Brammer, K. M. Khanna, D. Masopust, and L. Lefrancois. 2006. Evidence that a significant number of naive T cells enter non-lymphoid organs as part of a normal migratory pathway. Eur. J. Immunol. 36:1423-1433.
7. Davis, M. M., and P. J. Bjorkman. 1988. T-cell antigen receptor genes and T-cell recognition. Nature 334:395-402. (Pubitemid 18188024)
8. Ganusov, V. V., and R. J. De Boer. 2007. Do most lymphocytes in humans really reside in the gut? Trends Immunol. 28:514-518.
9. Gudmundsdottir, H., A. D. Wells, and L. A. Turka. 1999. Dynamics and requirements of T cell clonal expansion in vivo at the single-cell level: effector function is linked to proliferative capacity. J. Immunol. 162:5212-5223. (Pubitemid 29307126)
10. Haluszczak, C., A. D. Akue, S. E. Hamilton, L. D. Johnson, L. Pujanauski, L. Teodorovic, S. C. Jameson, and R. M. Kedl. 2009. The antigen-specific CD8+ T cell repertoire in unimmunized mice includes memory phenotype cells bearing markers of homeostatic expansion. J. Exp. Med. 206:435-448.
11. Kaech, S. M., and R. Ahmed. 2001. Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naive cells. Nat. Immunol. 2:415-422.
12. Kedzierska, K., E. B. Day, J. Pi, S. B. Heard, P. C. Doherty, S. J. Turner, and S. Perlman. 2006. Quantification of repertoire diversity of influenza-specific epitopes with predominant public or private TCR usage. J. Immunol. 177: 6705-6712. (Pubitemid 44715034)
13. Kim, S. K., M. Cornberg, X. Z. Wang, H. D. Chen, L. K. Selin, and R. M. Welsh. 2005. Private specificities of CD8 T cell responses control patterns of heterologous immunity. J. Exp. Med. 201:523-533.
14. + T-cell response to lymphocytic choriomeningitis virus involves the L antigen: uncovering new tricks for an old virus. J. Virol. 81:4928-4940.
15. Kotturi, M. F., I. Scott, T. Wolfe, B. Peters, J. Sidney, H. Cheroutre, M. G. von Herrath, M. J. Buchmeier, H. Grey, and A. Sette. 2008. Naive precursor frequencies and MHC binding rather than the degree of epitope diversity shape CD8+ T cell immunodominance. J. Immunol. 181:2124-2133.
16. Lyons, A. B., and C. R. Parish. 1994. Determination of lymphocyte division by flow cytometry. J. Immunol. Methods 171:131-137. (Pubitemid 24140219)
17. Mason, D. 1998. A very high level of crossreactivity is an essential feature of the T-cell receptor. Immunol. Today 19:395-404. (Pubitemid 28392279)
18. Mercado, R., S. Vijh, S. E. Allen, K. Kerksiek, I. M. Pilip, and E. G. Pamer. 2000. Early programming of T cell populations responding to bacterial infection. J. Immunol. 165:6833-6839. (Pubitemid 32001151)
19. Moon, J. J., H. H. Chu, M. Pepper, S. J. McSorley, S. C. Jameson, R. M. Kedl, and M. K. Jenkins. 2007. Naive CD4(+) T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude. Immunity 27:203-213.
20. Moutaftsi, M., B. Peters, V. Pasquetto, D. C. Tscharke, J. Sidney, H. H. Bui, H. Grey, and A. Sette. 2006. A consensus epitope prediction approach identifies the breadth of murine T(CD8+)-cell responses to vaccinia virus. Nat. Biotechnol. 24:817-819.
21. Murata, K., A. Garcia-Sastre, M. Tsuji, M. Rodrigues, D. Rodriguez, J. R. Rodriguez, R. S. Nussenzweig, P. Palese, M. Esteban, and F. Zavala. 1996. Characterization of in vivo primary and secondary CD8+ T cell responses induced by recombinant influenza and vaccinia viruses. Cell. Immunol. 173: 96-107.
22. Naumov, Y. N., E. N. Naumova, K. T. Hogan, L. K. Selin, and J. Gorski. 2003. A fractal clonotype distribution in the CD8+ memory T cell repertoire could optimize potential for immune responses. J. Immunol. 170:3994-4001.
23. Obar, J. J., K. M. Khanna, and L. Lefrancois. 2008. Endogenous naive CD8+ T cell precursor frequency regulates primary and memory responses to infection. Immunity 28:859-869.
24. Pewe, L., S. B. Heard, C. Bergmann, M. O. Dailey, and S. Perlman. 1999. Selection of CTL escape mutants in mice infected with a neurotropic coronavirus: quantitative estimate of TCR diversity in the infected central nervous system. J. Immunol. 163:6106-6113.
25. Pewe, L. L., J. M. Netland, S. B. Heard, and S. Perlman. 2004. Very diverse CD8 T cell clonotypic responses after virus infections. J. Immunol. 172:3151-3156. (Pubitemid 38263705)
26. Reed, L., and H. Muench. 1938. A simple method of estimating fifty per cent endpoints. Am. J. Epidemiol. 27:493.
27. Rizzuto, G. A., T. Merghoub, D. Hirschhorn-Cymerman, C. Liu, A. M. Lesokhin, D. Sahawneh, H. Zhong, K. S. Panageas, M. A. Perales, G. Altan-Bonnet, J. D. Wolchok, and A. N. Houghton. 2009. Self-antigen-specific CD8+ T cell precursor frequency determines the quality of the antitumor immune response. J. Exp. Med. 206:849-866.
28. Salek-Ardakani, S., M. Moutaftsi, S. Crotty, A. Sette, and M. Croft. 2008. OX40 drives protective vaccinia virus-specific CD8 T cells. J. Immunol. 181:7969-7976.
29. Selin, L. K., S. R. Nahill, and R. M. Welsh. 1994. Cross-reactivities in memory cytotoxic T lymphocyte recognition of heterologous viruses. J. Exp. Med. 179:1933-1943.
30. Selin, L. K., K. Vergilis, R. M. Welsh, and S. R. Nahill. 1996. Reduction of otherwise remarkably stable virus-specific cytotoxic T lymphocyte memory by heterologous viral infections. J. Exp. Med. 183:2489-2499.
31. Stemberger, C., K. M. Huster, M. Koffler, F. Anderl, M. Schiemann, H. Wagner, and D. H. Busch. 2007. A single naive CD8+ T cell precursor can develop into diverse effector and memory subsets. Immunity 27:985-997. (Pubitemid 50014865)
32. Tscharke, D. C., G. Karupiah, J. Zhou, T. Palmore, K. R. Irvine, S. M. Haeryfar, S. Williams, J. Sidney, A. Sette, J. R. Bennink, and J. W. Yewdell. 2005. Identification of poxvirus CD8+ T cell determinants to enable rational design and characterization of smallpox vaccines. J. Exp. Med. 201:95-104.
33. Varga, S. M., and R. M. Welsh. 1998. Detection of a high frequency of virus-specific CD4+ T cells during acute infection with lymphocytic choriomeningitis virus. J. Immunol. 161:3215-3218. (Pubitemid 128470611)
34. Welsh, R. M., Jr., P. W. Lampert, P. A. Burner, and M. B. Oldstone. 1976. Antibody-complement interactions with purified lymphocytic choriomeningitis virus. Virology 73:59-71.
35. Whitmire, J. K., N. Benning, and J. L. Whitton. 2006. Precursor frequency, nonlinear proliferation, and functional maturation of virus-specific CD4+ T cells. J. Immunol. 176:3028-3036.
36. Wilson, D. B., D. H. Wilson, K. Schroder, C. Pinilla, S. Blondelle, R. A. Houghten, and K. C. Garcia. 2004. Specificity and degeneracy of T cells. Mol. Immunol. 40:1047-1055.
37. Yager, E. J., M. Ahmed, K. Lanzer, T. D. Randall, D. L. Woodland, and M. A. Blackman. 2008. Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus. J. Exp. Med. 205:711-723.
38. Yang, H. Y., P. L. Dundon, S. R. Nahill, and R. M. Welsh. 1989. Virusinduced polyclonal cytotoxic T lymphocyte stimulation. J. Immunol. 142: 1710-1718.
39. Zehn, D., S. Y. Lee, and M. J. Bevan. 2009. Complete but curtailed T-cell response to very low-affinity antigen. Nature 458:211-214.