Acetaminophen and neural degeneration: Is there a possible link?

Medical Hypotheses

Volumn 74, Issue 2, 2010, Pages 390-391

  Ye, Ming Xiang ^a   Li, Jin Lian ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; GLUTATHIONE; INTERLEUKIN 1; MACROPHAGE INFLAMMATORY PROTEIN; MENADIONE; PARACETAMOL; PROTEIN BCL 2; TUMOR NECROSIS FACTOR ALPHA;

ANALGESIC ACTIVITY; ANTIPYRETIC ACTIVITY; APOPTOSIS; BLOOD BRAIN BARRIER; CENTRAL NERVOUS SYSTEM; DOPAMINERGIC NERVE CELL; DRUG METABOLISM; DRUG POTENTIATION; HUMAN; LETTER; LIVER FAILURE; LIVER NECROSIS; NERVE CELL; NERVE CELL DEGENERATION; NERVE CELL NECROSIS; OXIDATIVE STRESS; PRIORITY JOURNAL; SUBSTANTIA NIGRA;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; BRAIN; HUMANS; INCIDENCE; MODELS, NEUROLOGICAL; NEURODEGENERATIVE DISEASES;

EID: 72749102923     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2009.09.028     Document Type: Letter

References (4)

1. Sharpe R.J. Acetaminophen: the case for a link to neurodegenerative diseases. Med Hypotheses 71 (2008) 813-814
2. Schulz J.B., Lindenau J., Seyfried J., et al. Glutathione, oxidative stress and neurodegeneration. Eur J Biochem 267 (2000) 4904-4911
3. Locke C.J., Fox S.A., Caldwell G.A., et al. Acetaminophen attenuates dopamine neuron degeneration in animal models of Parkinson's disease. Neurosci Lett 439 (2008) 129-133
4. Tripathy D., and Grammas P. Acetaminophen inhibits neuronal inflammation and protects neurons from oxidative stress. J Neuroinflamm 6 (2009) 10