Trabecular bone structure analysis in the osteoporotic spine using a clinical in vivo setup for 64-slice MDCT imaging: Comparison to μCT imaging and μFE modeling

Journal of Bone and Mineral Research

Volumn 24, Issue 9, 2009, Pages 1628-1637

  Issever, Ahi Sema ^a,b   Link, Thomas M ^b   Kentenich, Marie ^a,b   Rogalla, Patrik ^a   Schwieger, Karsten ^c   Huber, Markus B ^b   Burghardt, Andrew J ^b   Majumdar, Sharmila ^b   Diederichs, Gerd ^a,b  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c AO RESEARCH INSTITUTE   (Switzerland)

Author keywords

CT; Multidetector CT; Spine; Structure analysis; Trabecular bone

Indexed keywords

AGED; ARTICLE; BONE DENSITY; BONE STRUCTURE; CADAVER; CLINICAL ASSESSMENT; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; FINITE ELEMENT ANALYSIS; HUMAN; IMAGE ANALYSIS; IMAGE QUALITY; IN VIVO CULTURE; LUMBAR VERTEBRA; MALE; MICRO-COMPUTED TOMOGRAPHY; MULTIDETECTOR COMPUTED TOMOGRAPHY; OSTEOPOROSIS; PARAMETER; SPINAL OSTEOPOROSIS; STRENGTH; STRUCTURE ANALYSIS; THICKNESS; TRABECULAR BONE;

BONE AND BONES; BONE DENSITY; FINITE ELEMENT ANALYSIS; HUMANS; MODELS, BIOLOGICAL; OSTEOPOROSIS; SPINE; TOMOGRAPHY, X-RAY COMPUTED;

EID: 72749102523     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.090311     Document Type: Article

References (52)

1. Cummings SR 1985 Are patients with hip fractures more osteoporotic? Review of the evidence. Am J Med 78:487-494.
2. Ott SM 1993 When bone mass fails to predict bone failure. Calcif Tissue Int 53(Suppl 1):S7-S13. (Pubitemid 23277161)
3. Siris ES, Chen YT, Abbott TA, Barrett-Connor E, Miller PD, Wehren LE, Berger ML 2004 Bone mineral density thresholds for pharmacological intervention to prevent fractures. Arch Intern Med 164:1108-1112. (Pubitemid 38668990)
4. Cummings SR, Karpf DB, Harris F, Genant HK, Ensrud K, LaCroix AZ, Black DM 2002 Improvement in spine bone density and reduction in risk of vertebral fractures during treatment with antiresorptive drugs. Am J Med 112:281-289. (Pubitemid 34219441)
5. Riggs BL, Melton LJ III 2002 Bone turnover matters: The raloxifene treatment paradox of dramatic decreases in vertebral fractures without commensurate increases in bone density. J Bone Miner Res 17:11-14.
6. Sarkar S, Mitlak BH, Wong M, Stock JL, Black DM, Harper KD 2002 Relationships between bone mineral density and incident vertebral fracture risk with raloxifene therapy. J Bone Miner Res 17:1-10. (Pubitemid 33150990)
7. Bouxsein ML 2003 Bone quality: Where do we go from here? Osteoporos Int 14(Suppl 5):S118-S127.
8. Seeman E, Delmas PD 2006 Bone quality-the material and structural basis of bone strength and fragility. N Engl J Med 354:2250-2261. (Pubitemid 43788139)
9. Kleerekoper M, Villanueva AR, Stanciu J, Rao DS, Parfitt AM 1985 The role of three-dimensional trabecular microstructure in the pathogenesis of vertebral compression fractures. Calcif Tissue Int 37:594-597. (Pubitemid 16197165)
10. McDonnell P, McHugh PE, O'Mahoney D 2007 Vertebral osteoporosis and trabecular bone quality. Ann Biomed Eng 35:170-189. (Pubitemid 46122174)
11. Silva MJ 2007 Biomechanics of osteoporotic fractures. Injury 38(Suppl 3):S69-S76.
12. Boutroy S, Bouxsein ML, Munoz F, Delmas PD 2005 In vivo assessment of trabecular bone microarchitecture by highresolution peripheral quantitative computed tomography. J Clin Endocrinol Metab 90:6508-6515.
13. Kazakia GJ, Hyun B, Burghardt AJ, Krug R, Newitt DC, de Papp AE, Link TM, Majumdar S 2008 In Vivo Determination of Bone Structure in Postmenopausal Women: A Comparison of HR-pQCT and High-Field MR Imaging. J Bone Miner Res 23:463-474.
14. Ito M, Ikeda K, Nishiguchi M, Shindo H, Uetani M, Hosoi T, Orimo H 2005 Multi-detector row CT imaging of vertebral microstructure for evaluation of fracture risk. J Bone Miner Res 20:1828-1836. (Pubitemid 41361884)
15. Graeff C, Timm W, Nickelsen TN, Farrerons J, Marin F, Barker C, Gluer CC 2007 Monitoring teriparatide-associated changes in vertebral microstructure by high-resolution CT in vivo: Results from the EUROFORS study. J Bone Miner Res 22:1426-1433. (Pubitemid 351339687)
16. Thomsen JS, Laib A, Koller B, Prohaska S, Mosekilde L, Gowin W 2005 Stereological measures of trabecular bone structure: Comparison of 3D micro computed tomography with 2D histological sections in human proximal tibial bone biopsies. J Microsc 218:171-179. (Pubitemid 40646647)
17. Muller R, Van Campenhout H, Van Damme B, Van Der Perre G, Dequeker J, Hildebrand T, Ruegsegger P 1998 Morphometric analysis of human bone biopsies: A quantitative structural comparison of histological sections and micro-computed tomography. Bone 23:59-66. (Pubitemid 28327502)
18. Ruegsegger P, Koller B, Muller R 1996 A microtomographic system for the nondestructive evaluation of bone architecture. Calcif Tissue Int 58:24-29. (Pubitemid 26028374)
19. Genant HK, Wu CY, van Kuijk C, Nevitt MC 1993 Vertebral fracture assessment using a semiquantitative technique. J Bone Miner Res 8:1137-1148. (Pubitemid 23261108)
20. Majumdar S, Genant HK 1997 Assessment of trabecular structure using high resolution magnetic resonance imaging. Stud Health Technol Inform 40:81-96. (Pubitemid 127103327)
21. Ridler TW 1978 Picture Thresholding Using an Iterative Selection Method. IEEE Trans Syst Man Cybern 8:630-632. (Pubitemid 8623043)
22. Odgaard A 1997 Three-dimensional methods for quantification of cancellous bone architecture. Bone 20:315-328. (Pubitemid 27196654)
23. Hildebrand T, Ruegsegger P 1997 Quantification of bone microarchitecture with the structure model index. Comput Methods Biomech Biomed Engin 1:15-23.
24. Hildebrand T, Laib A, Muller R, Dequeker J, Ruegsegger P 1999 Direct three-dimensional morphometric analysis of human cancellous bone: Microstructural data from spine, femur, iliac crest, and calcaneus. J Bone Miner Res 14:1167-1174. (Pubitemid 29314060)
25. Jiang C, GigerML, ChinanderMR,Martell JM, Kwak S, Favus MJ 1999 Characterization of bone quality using computer-extracted radiographic features. Med Phys 26:872-879. (Pubitemid 29284104)
26. Maragos P 1994 Fractal signal analysis using mathematical morphology. Adv Electron Electron Phys 88:199-246.
27. Boehm HF, Link TM, Monetti RA, Kuhn V, Eckstein F, Raeth CW, Reiser M 2006 Analysis of the topological properties of the proximal femur on a regional scale: Evaluation of multi-detector CT-scans for the assessment of biomechanical strength using Local minkowski functionals in 3D. Proc SPIE 6144:61446x7-61446x8.
28. Boehm HF, Vogel T, Panteleon A, Burklein D, Bitterling H, Reiser M 2007 Differentiation between post-menopausal women with and without hip fractures: Enhanced evaluation of clinical DXA by topological analysis of the mineral distribution in the scan images. Osteoporos Int 18:779-787. (Pubitemid 46684781)
29. Haralick RM, Shanmugam K, Dinstein I 1973 Textural features for image classification. IEEE Trans Syst Man Cybern 3:610-621.
30. Anys H, He DC 1995 Evaluation of textural and multipolarization radar features for crop classification. IEEE Trans Geosci Rem Sens 33:1170-1181.
31. Boehm HF, Raeth C, Monetti RA, Mueller D, Newitt D, Majumdar S, Rummeny E, Morfill G, Link TM 2003 Local 3D scaling properties for the analysis of trabecular bone extracted from high-resolution magnetic resonance imaging of human trabecular bone: Comparison with bone mineral density in the prediction of biomechanical strength in vitro. Invest Radiol 38:269-280. (Pubitemid 36535033)
32. Jamitzky F, Stark RW, Bunk W, Thalhammer S, Rath C, Aschenbrenner T, Morfill GE, Heckl WM 2001 Scaling-index method as an image processing tool in scanning-probe microscopy. Ultramicroscopy 86:241-246. (Pubitemid 32101378)
33. Pompl R, Bunk W, Horst A, Stolz W, Abmayr W, Brauner W, Glaessl A, Morfill G 2000 MELDOQ: Ein System zur Unterstützung der Früherkennung des malignen Melanoms durch digitale Bildverarbeitung. Bildverarbeitung für die Medizin. Springer, Berlin, Germany.
34. Muller R, Ruegsegger P 1995 Three-dimensional finite element modelling of non-invasively assessed trabecular bone structures. Med Eng Phys 17:126-133.
35. Van Rietbergen B, Weinans H, Huiskes R, Odgaard A 1995 A new method to determine trabecular bone elastic properties and loading using micromechanical finite-element models. J Biomech 28:69-81. (Pubitemid 24343733)
36. Van Rietbergen B, Odgaard A, Kabel J, Huiskes R 1996 Direct mechanics assessment of elastic symmetries and properties of trabecular bone architecture. J Biomech 29:1653-1657. (Pubitemid 26381880)
37. Felsenberg D, Gowin W 1999 [Bone densitometry by dual energy methods]. Radiologe 39:186-193.
38. Ammann P, Rizzoli R 2003 Bone strength and its determinants. Osteoporos Int 14(Suppl 3):S13-S18.
39. Yeni YN, Brown CU, Wang Z, Norman TL 1997 The influence of bone morphology on fracture toughness of the human femur and tibia. Bone 21:453-459. (Pubitemid 27485315)
40. MacNeil JA, Boyd SK 2007 Accuracy of high-resolution peripheral quantitative computed tomography for measurement of bone quality. Med Eng Phys 29:1096-1105. (Pubitemid 350052626)
41. Bauer JS, Link TM, Burghardt A, Henning TD, Mueller D, Majumdar S, Prevrhal S 2007 Analysis of trabecular bone structure with multidetector spiral computed tomography in a simulated soft-tissue environment. Calcif Tissue Int 80:366-373. (Pubitemid 46956764)
42. Bauer JS, Issever AS, Fischbeck M, Burghardt A, Eckstein F, Rummeny EJ, Majumdar S, Link TM 2004 [Multislice-CT for structure analysis of trabecular bone: A comparison with micro-CT and biomechanical strength]. Rofo 176:709-718.
43. Chevalier F, Laval-Jeantet AM, Laval-Jeantet M, Bergot C 1992 CT image analysis of the vertebral trabecular network in vivo. Calcif Tissue Int 51:8-13.
44. Gordon CL, Lang TF, Augat P, Genant HK 1998 Image-based assessment of spinal trabecular bone structure from high-resolution CT images. Osteoporos Int 8:317-325. (Pubitemid 28418265)
45. Ito M, Ohki M, Hayashi K, Yamada M, Uetani M, Nakamura T 1995 Trabecular texture analysis of CT images in the relationship with spinal fracture. Radiology 194:55-59. (Pubitemid 24380922)
46. Mundinger A, Wiesmeier B, Dinkel E, Helwig A, Beck A, Schulte Moenting J 1993 Quantitative image analysis of vertebral body architecture-improved diagnosis in osteoporosis based on high-resolution computed tomography. Br J Radiol 66:209-213. (Pubitemid 23096973)
47. Muller R, Koller B, Hildebrand T, Laib A, Gianolini S, Ruegsegger P 1996 Resolution dependency of microstructural properties of cancellous bone based on three-dimensional mutomography. Technol Health Care 4:113-119. (Pubitemid 27062335)
48. Arlot ME, Burt-Pichat B, Roux JE, Vashishth D, Bouxsein ML, Delmas PD 2008 Microarchitecture influences microdamage accumulation in human vertebral trabecular bone. J Bone Miner Res 23:1613-1618.
49. Apostol L, Boudousq V, Basset O, Odet C, Yot S, Tabary J, Dinten JM, Boiler E, Kotzki PO, Peyrin F 2006 Relevance of 2D radiographic texture analysis for the assessment of 3D bone micro-architecture. Med Phys 33:3546-3556. (Pubitemid 44327458)
50. Lin JC, Grampp S, Link T, Kothari M, Newitt DC, Felsenberg D, Majumdar S 1999 Fractal analysis of proximal femur radiographs: Correlation with biomechanical properties and bone mineral density. Osteoporos Int 9:516-524. (Pubitemid 29348567)
51. Pothuaud L, Carceller P, Hans D 2008 Correlations between grey-level variations in 2D projection images (TBS) and 3D microarchitecture: Applications in the study of human trabecular bone microarchitecture. Bone 42:775-787.
52. Vokes TJ, Giger ML, Chinander MR, Karrison TG, Favus MJ, Dixon LB 2006 Radiographic texture analysis of densitometer-generated calcaneus images differentiates postmenopausal women with and without fractures. Osteoporos Int 17:1472-1482.