Disrupted Temporal Control in the R6/2 Mouse Model of Huntington's Disease

Behavioral Neuroscience

Volumn 123, Issue 6, 2009, Pages 1353-1358

  Balci, Fuat ^a,b   Day, Mark ^c,d   Rooney, Aislinn ^a   Brunner, Dani ^a,e  

^a PSYCHOGENICS INC   (United States)

^b PRINCETON UNIVERSITY   (United States)

^c ABBOTT LABORATORIES   (United States)

^d UNIVERSITY OF ABERDEEN   (United Kingdom)

^e Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

corticostriatal circuit; Huntington's disease; interval timing; mice; peak procedure

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR; CONDITIONED REFLEX; CONTROLLED STUDY; FEMALE; HUNTINGTON CHOREA; INSTRUMENTAL CONDITIONING; MOUSE; NEUROBIOLOGY; NEUROPATHOLOGY; NEUROPSYCHOLOGICAL TEST; NONHUMAN; PHENOTYPE; REINFORCEMENT; STIMULUS RESPONSE; TIME PERCEPTION; TRANSGENIC MOUSE; TRINUCLEOTIDE REPEAT; WILD TYPE;

ANALYSIS OF VARIANCE; ANIMALS; CONDITIONING, OPERANT; DISEASE MODELS, ANIMAL; FEMALE; HUNTINGTON DISEASE; MALE; MICE; MICE, TRANSGENIC; TIME PERCEPTION; TRINUCLEOTIDE REPEAT EXPANSION;

EID: 72549116885     PISSN: 07357044     EISSN: None     Source Type: Journal    
DOI: 10.1037/a0017650     Document Type: Article

References (35)

1. Abner R.T., Edwards T., Douglas A., and Brunner D. Pharmacology of temporal cognition in two mouse strains. International Journal of Comparative Psychology 14 (2001) 189-210
2. Balci F., Gallistel C.R., Allen B.D., Frank K., Gibson J., and Brunner D. Acquisition of peak responding: What is learned?. Behavioral Processes 80 (2009) 67-75
3. Balci F., Meck W., Moore H., and Brunner D. Timing deficits in aging and neuropathology. In: Bizon J.L., and Woods A.G. (Eds). Animal models of human cognitive aging (2009), Humana Press, Totowa, NJ 161-201
4. Beste C., Saft C., Andrich J., Muller T., Gold R., and Falkenstein M. Time Processing in Huntington's disease: A group-control study. PLoS One 12 (2007) e1263
5. Brunner D., Kacelnik A., and Gibbon J. Optimal foraging and timing processes in the starling, Sturnus vulgaris: Effect of inter-capture interval. Animal Behavior 44 (1992) 597-613
6. Catania A.C. Reinforcement schedules and psychophysical judgments: A study of some temporal properties of behavior. In: Schoenfeld W.N. (Ed). The theory of reinforcement schedules (1970), Appleton-Century-Crofts, New York, NY 1-42
7. Cepeda C., Hurst R.S., Calvert C.R., Hernandez-Echeagaray E., Nguyen O.K., Jocoy E., and Levine M.S. Transient and progressive electrophysiological alterations in the corticostriatal pathway in a mouse model of Huntington's disease. Journal of Neuroscience 23 (2003) 961-969
8. Cepeda C., Wu N., Andre V.M., Cummings D.M., and Levine M.S. The corticostriatal pathway in Huntington's disease. Progress in Neurobiology 81 (2007) 253-271
9. Cha J.-H.J., Kosinski C.M., Kerner J.A., Alsdorf S.A., Mangiarini L., Davies S.W., Penney J.B., Bates G.P., and Young A.B. Altered brain neurotransmitter receptors in transgenic mice expressing a portion of an abnormal human Huntington disease gene. Proceedings of the National Academy of Sciences of the United States of America 95 (1998) 6480-6485
10. Coull J.T., Vidal F., Nazarian B., and Macar F. Functional anatomy of the attentional modulation of time estimation. Science 303 (2004) 1506-1508
11. Gallistel C.R., Balsam P.D., and Fairhurst S. The learning curve: Implications of a quantitative analysis. Proceedings of the National Academy of Sciences 101 (2004) 13124-13131
12. Gallistel C.R., King A., and McDonald R. Sources of variability and systematic error in mouse timing behavior. Journal of Experimental Psychology: Animal Behavior Processes 30 (2004) 3-16
13. Hinton S.C., Paulsen J.S., Hoffmann R.G., Reynolds N.C., Zimbelman J.L., and Rao S.M. Motor timing variability increases in preclinical Huntington's disease patients as estimated onset of motor symptoms approaches. Journal of the International Neuropsychological Society 13 (2007) 539-543
14. Jonkman S., Mar A.C., Dickinson A., Robbins T.W., and Everitt B.J. The rat prelimbic cortex mediates inhibitory response control but not the consolidation of instrumental learning. Behavioral Neuroscience 123 (2009) 875-885
15. Johnson M.A., Rajan V., Miller C.E., and Wightman R.M. Dopamine release is severely compromised in the R6/2 mouse model of Huntington's disease. Journal of Neurochemistry 97 3 (2006) 737-746
16. Klapstein G.J., Fisher R.S., Zanjani H., Cepeda C., Jokel E.S., Chesselet M.F., and Levine M.S. Electrophysiological and morphological changes in striatal spiny neurons in R6/2 Huntington's disease transgenic mice. Journal of Neurophysiology 86 (2001) 2667-2677
17. Kung V.W.S., Hassam R., Morton A.J., and Jones S. Dopamine-dependent long term potentiation in the dorsal striatum is reduced in the R6/2 mouse model of Huntington's disease. The Journal of Neuroscience 146 (2007) 1571-1580
18. Lisman J.E. Bursts as a unit of neural information: making unreliable synapses reliable. Trends in Neuroscience 20 (1997) 38-43
19. Ludvig E., Conover K., and Shizgal P. The effects of reward magnitude on timing in rats. Journal of the Experimental Analysis of Behavior 87 (2007) 201-218
20. Mangiarini L., Sathasivam K., Seller M., Cozens B., Harper A., Hetherington C., Lawton M., Trottier Y., Lehrach H., Davies S.W., and Bates G.P. Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice. Cell 87 (1996) 493-506
21. Matell M.S., and Meck W.H. Cortico-striatal circuits and interval timing: Coincidence detection of oscillatory processes. Cognitive Brain Research 21 (2004) 139-170
22. Meck W.H. Neuropharmacology of timing and time perception. Cognitive Brain Research 3 (1996) 227-242
23. Meck W.H. Neuroanatomical localization of an internal clock: A functional link between mesolimbic, nigrostriatal, and mesocortical dopaminergic systems. Brain Research 1109 (2006) 93-107
24. Menalled L., El-Khodor B.F., Patry M., Suarez-Farinas M., Orenstein S.J., Zahasky B., and Brunner D. Systematic behavioral evaluation of Huntington's disease transgenic and knock-in mouse models. Neurobiology of Disease 35 3 (2009) 319-336 doi:10.1016/j.nbd. 2009.05.007
25. Miller B.R., Walker A.G., Shah A.S., Barton S.J., and Rebec G.V. Dysregulated information processing by medium-spiny neurons in striatum of freely behaving mouse models of Huntington's disease. Journal of Neurophysiology 100 4 (2008) 2205-2216
26. Morton A.J., Skillings E., Bussey T.J., and Saksida L.M. Measuring cognitive deficits in disabled mice using an automated interactive touchscreen system. Nature Methods 3 (2006) 767
27. National Research Council. Guide for the care and use of laboratory animals (1996), National Academy, Washington, DC
28. Oakeshott, S. M., Balci, F., Howland, D., Balleine, B. W., & Brunner, D. (in preparation). Simple instrumental conditioning deficits in HD mouse models
29. Paulsen J.S., Zhao H., Sout J.C., Brinkman R.R., Guttman M., Ross C.A., and Shoulson I. Clinical markers of early disease in persons near onset of Huntington's disease. Neurology 57 (2001) 658-662
30. Paulsen J.S., Zimbelman J.L., Hinton S.C., Langbehn D.R., Leveroni C.L., Benjamin M.L., and Rao S.M. fMRI biomarker of early neuronal dysfunction in presymptomatic Huntington's disease. American Journal of Neuroradiology 25 (2004) 1715-1721
31. Rakitin B.C., Hinton S.C., Penney T.B., Malapani C., Gibbon J., and Meck W.H. Scalar expectancy theory and peak-interval timing in humans. Journal of Experimental Psychology: Animal Behavior Processes 24 (1998) 1-19
32. Robertson G.S., Vincent S.R., and Fibiger H.C. D1 and D2 dopamine receptors differentially regulate c-fos expression in striatonigral and striatopallidal neurons. Neuroscience 49 (1992) 285-296
33. Rosas H.D., Feigin A.S., and Hersch S.M. Using advances in neuroimaging to detect, understand, and monitor disease progression in Huntington's disease. NeuroRx 1 (2004) 263-271
34. Turmaine M., Raza A., Mahal A., Mangiarini L., Bates G.P., and Davies S.W. Nonapoptotic neurodegeneration in a transgenic mouse model of Huntington's disease. PNAS USA 97 (2000) 8093-8097
35. Walker A.G., Miller B.R., Fritsch J.N., Barton S.J., and Rebec G.V. Altered information processing in the prefrontal cortex of Huntington's disease mouse models. Journal of Neuroscience 28 36 (2008) 8973-8982