메뉴 건너뛰기




Volumn 7, Issue 3, 2009, Pages 96-102

Strontium ranelate: New data on fracture prevention and mechanisms of action

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; COLECALCIFEROL; PLACEBO; STRONTIUM RANELATE;

EID: 72449204568     PISSN: 15441873     EISSN: 15442241     Source Type: Journal    
DOI: 10.1007/s11914-009-0016-1     Document Type: Review
Times cited : (5)

References (40)
  • 1
    • 44649120398 scopus 로고    scopus 로고
    • European guidance for the diagnosis and management of osteoporosis in postmenopausal women
    • 18266020 10.1007/s00198-008-0560-z 1:STN:280:DC%2BD1c3itFekuw%3D%3D
    • J.A. Kanis N. Burlet C. Cooper, et al. 2008 European guidance for the diagnosis and management of osteoporosis in postmenopausal women Osteoporos Int 19 399 428 18266020 10.1007/s00198-008-0560-z 1:STN:280:DC%2BD1c3itFekuw%3D%3D
    • (2008) Osteoporos Int , vol.19 , pp. 399-428
    • Kanis, J.A.1    Burlet, N.2    Cooper, C.3
  • 2
    • 42349096158 scopus 로고    scopus 로고
    • Pharmacological topics of bone metabolism: Recent advances in pharmacological management of osteoporosis
    • DOI 10.1254/jphs.FM0070218
    • A. Suzuki S. Sekiguchi S. Asano M. Itoh 2008 Pharmacological topics of bone metabolism: recent advances in pharmacological management of osteoporosis J Pharmacol Sci 106 530 535 18431035 10.1254/jphs.FM0070218 1:CAS:528: DC%2BD1cXltlCjsrk%3D (Pubitemid 351556228)
    • (2008) Journal of Pharmacological Sciences , vol.106 , Issue.4 , pp. 530-535
    • Suzuki, A.1    Sekiguchi, S.2    Asano, S.3    Itoh, M.4
  • 3
    • 58149465400 scopus 로고    scopus 로고
    • Vitamin D status and response to treatment in post-menopausal osteoporosis
    • 18551242 10.1007/s00198-008-0650-y 1:CAS:528:DC%2BD1MXktVSgtA%3D%3D
    • S. Adami S. Giannini G. Bianchi, et al. 2009 Vitamin D status and response to treatment in post-menopausal osteoporosis Osteoporos Int 20 239 244 18551242 10.1007/s00198-008-0650-y 1:CAS:528:DC%2BD1MXktVSgtA%3D%3D
    • (2009) Osteoporos Int , vol.20 , pp. 239-244
    • Adami, S.1    Giannini, S.2    Bianchi, G.3
  • 4
    • 53549117736 scopus 로고    scopus 로고
    • Low incidence of anti-osteoporosis treatment after hip fracture
    • 18829912 10.2106/JBJS.G.00864
    • V. Rabenda J. Vanoverloop V. Fabri, et al. 2008 Low incidence of anti-osteoporosis treatment after hip fracture J Bone Joint Surg Am 90 2142 2148 18829912 10.2106/JBJS.G.00864
    • (2008) J Bone Joint Surg Am , vol.90 , pp. 2142-2148
    • Rabenda, V.1    Vanoverloop, J.2    Fabri, V.3
  • 5
    • 33847012162 scopus 로고    scopus 로고
    • Strontium ranelate in the prevention of osteoporotic fractures
    • DOI 10.1111/j.1742-1241.2006.01249.x
    • J.Y. Reginster O. Malaise A. Neuprez O. Bruyere 2007 Strontium ranelate in the prevention of osteoporotic fractures Int J Clin Pract 61 324 328 17263720 10.1111/j.1742-1241.2006.01249.x 1:CAS:528:DC%2BD2sXjs1Wks7w%3D (Pubitemid 46271298)
    • (2007) International Journal of Clinical Practice , vol.61 , Issue.2 , pp. 324-328
    • Reginster, J.-Y.1    Malaise, O.2    Neuprez, A.3    Bruyere, O.4
  • 7
    • 0030176233 scopus 로고    scopus 로고
    • The divalent strontium salt S12911 enhances bone cell replication and bone formation in vitro
    • DOI 10.1016/8756-3282(96)00080-4
    • E. Canalis M. Hott P. Deloffre, et al. 1996 The divalent strontium salt S12911 enhances bone cell replication and bone formation in vitro Bone 18 517 523 8805991 10.1016/8756-3282(96)00080-4 1:CAS:528:DyaK28Xkslagu7k%3D (Pubitemid 26257871)
    • (1996) Bone , vol.18 , Issue.6 , pp. 517-523
    • Canalis, E.1    Hott, M.2    Deloffre, P.3    Tsouderos, Y.4    Marie, P.J.5
  • 8
    • 0037118899 scopus 로고    scopus 로고
    • In vitro effects of S12911-2 on osteoclast function and bone marrow macrophage differentiation
    • DOI 10.1016/S0014-2999(02)02040-X, PII S001429990202040X
    • R. Baron Y. Tsouderos 2002 In vitro effects of S12911-2 on osteoclast function and bone marrow macrophage differentiation Eur J Pharmacol 450 11 17 12176103 10.1016/S0014-2999(02)02040-X 1:CAS:528:DC%2BD38XmtlKjsb8%3D (Pubitemid 34899590)
    • (2002) European Journal of Pharmacology , vol.450 , Issue.1 , pp. 11-17
    • Baron, R.1    Tsouderos, Y.2
  • 9
    • 0142122898 scopus 로고    scopus 로고
    • S 12911-2 Inhibits Osteoclastic Bone Resorption In Vitro
    • DOI 10.1359/jbmr.2003.18.6.1082
    • N. Takahashi T. Sasaki Y. Tsouderos T. Suda 2003 S 12911-2 inhibits osteoclastic bone resorption in vitro J Bone Miner Res 18 1082 1087 12817762 10.1359/jbmr.2003.18.6.1082 1:CAS:528:DC%2BD3sXkslOhsbk%3D (Pubitemid 37294946)
    • (2003) Journal of Bone and Mineral Research , vol.18 , Issue.6 , pp. 1082-1087
    • Takahashi, N.1    Sasaki, T.2    Tsouderos, Y.3    Suda, T.4
  • 10
    • 58649120832 scopus 로고    scopus 로고
    • The calcium-sensing receptor is involved in strontium ranelate-induced osteoclast apoptosis. New insights into the associated signaling pathways
    • 18927086 10.1074/jbc.M801668200 1:CAS:528:DC%2BD1cXhsFCjtLjM
    • A.S. Hurtel-Lemaire R. Mentaverri A. Caudrillier, et al. 2009 The calcium-sensing receptor is involved in strontium ranelate-induced osteoclast apoptosis. New insights into the associated signaling pathways J Biol Chem 284 575 584 18927086 10.1074/jbc.M801668200 1:CAS:528:DC%2BD1cXhsFCjtLjM
    • (2009) J Biol Chem , vol.284 , pp. 575-584
    • Hurtel-Lemaire, A.S.1    Mentaverri, R.2    Caudrillier, A.3
  • 11
    • 33646089223 scopus 로고    scopus 로고
    • Strontium ranelate - Data on vertebral and nonvertebral fracture efficacy and safety: Mechanism of action
    • DOI 10.1007/s11914-006-0013-6
    • D.L. Kendler 2006 Strontium ranelate-data on vertebral and nonvertebral fracture efficacy and safety: mechanism of action Curr Osteoporos Rep 4 34 39 16527006 10.1007/s11914-006-0013-6 (Pubitemid 44623946)
    • (2006) Current Osteoporosis Reports , vol.4 , Issue.1 , pp. 34-39
    • Kendler, D.L.1
  • 12
    • 0027316220 scopus 로고
    • An uncoupling agent containing strontium prevents bone loss by depressing bone resorption and maintaining bone formation in estrogen-deficient rats
    • 8511988 1:CAS:528:DyaK2cXksFSjsbs%3D
    • P.J. Marie M. Hott D. Modrowski, et al. 1993 An uncoupling agent containing strontium prevents bone loss by depressing bone resorption and maintaining bone formation in estrogen-deficient rats J Bone Miner Res 8 607 615 8511988 1:CAS:528:DyaK2cXksFSjsbs%3D
    • (1993) J Bone Miner Res , vol.8 , pp. 607-615
    • Marie, P.J.1    Hott, M.2    Modrowski, D.3
  • 13
    • 0028999383 scopus 로고
    • Effects of strontium on calcium metabolism in rats. II. Strontium prevents the increased rate of bone turnover in ovariectomized rats
    • 7563972 10.1254/jjp.68.153 1:CAS:528:DyaK2MXmsFequ74%3D
    • T. Morohashi T. Sano K. Harai S. Yamada 1995 Effects of strontium on calcium metabolism in rats. II. Strontium prevents the increased rate of bone turnover in ovariectomized rats Jpn J Pharmacol 68 153 159 7563972 10.1254/jjp.68.153 1:CAS:528:DyaK2MXmsFequ74%3D
    • (1995) Jpn J Pharmacol , vol.68 , pp. 153-159
    • Morohashi, T.1    Sano, T.2    Harai, K.3    Yamada, S.4
  • 15
    • 24144474976 scopus 로고    scopus 로고
    • Long-term strontium ranelate administration in monkeys preserves characteristics of bone mineral crystals and degree of mineralization of bone
    • DOI 10.1359/JBMR.050405
    • D. Farlay G. Boivin G. Panczer, et al. 2005 Long-term strontium ranelate administration in monkeys preserves characteristics of bone mineral crystals and degree of mineralization of bone J Bone Miner Res 20 1569 1578 16059629 10.1359/JBMR.050405 1:CAS:528:DC%2BD2MXhtVOltrvO (Pubitemid 41243546)
    • (2005) Journal of Bone and Mineral Research , vol.20 , Issue.9 , pp. 1569-1578
    • Farlay, D.1    Boivin, G.2    Panczer, G.3    Lalande, A.4    Meunier, P.J.5
  • 18
    • 0141834679 scopus 로고    scopus 로고
    • Design and methodology of the phase 3 trials for the clinical development of strontium ranelate in the treatment of women with postmenopausal osteoporosis
    • 12730769 1:CAS:528:DC%2BD3sXjslWhs7k%3D
    • P.J. Meunier J.Y. Reginster 2003 Design and methodology of the phase 3 trials for the clinical development of strontium ranelate in the treatment of women with postmenopausal osteoporosis Osteoporos Int 14 Suppl3 S66 S76 12730769 1:CAS:528:DC%2BD3sXjslWhs7k%3D
    • (2003) Osteoporos Int , vol.14 , Issue.SUPPL3
    • Meunier, P.J.1    Reginster, J.Y.2
  • 19
    • 0027219544 scopus 로고
    • Vertebral fracture assessment using a semiquantitative technique
    • 8237484 1:STN:280:DyaK2c%2FlsFyhuw%3D%3D
    • H.K. Genant C.Y. Wu C. van Kuijk M.C. Nevitt 1993 Vertebral fracture assessment using a semiquantitative technique J Bone Miner Res 8 1137 1148 8237484 1:STN:280:DyaK2c%2FlsFyhuw%3D%3D
    • (1993) J Bone Miner Res , vol.8 , pp. 1137-1148
    • Genant, H.K.1    Wu, C.Y.2    Van Kuijk, C.3    Nevitt, M.C.4
  • 20
    • 0002454130 scopus 로고    scopus 로고
    • Strontium ranelate reduces the vertebral fracture risk in women with postmenopausal osteoporosis
    • P.J. Meunier C. Roux S. Ortolani 2002 Strontium ranelate reduces the vertebral fracture risk in women with postmenopausal osteoporosis Osteoporos Int 13 45
    • (2002) Osteoporos Int , vol.13 , pp. 45
    • Meunier, P.J.1    Roux, C.2    Ortolani, S.3
  • 21
    • 33645353336 scopus 로고    scopus 로고
    • Vertebral fracture risk reduction with strontium ranelate in women with postmenopausal osteoporosis is independent of baseline risk factors
    • 16598373 10.1359/jbmr.060101 1:CAS:528:DC%2BD28Xkt1Kqsrc%3D
    • C. Roux J.Y. Reginster J. Fechtenbaum, et al. 2006 Vertebral fracture risk reduction with strontium ranelate in women with postmenopausal osteoporosis is independent of baseline risk factors J Bone Miner Res 21 536 542 16598373 10.1359/jbmr.060101 1:CAS:528:DC%2BD28Xkt1Kqsrc%3D
    • (2006) J Bone Miner Res , vol.21 , pp. 536-542
    • Roux, C.1    Reginster, J.Y.2    Fechtenbaum, J.3
  • 23
    • 0036342982 scopus 로고    scopus 로고
    • Does a fracture at one site predict later fractures at other sites? A British cohort study
    • DOI 10.1007/s001980200084
    • T.P. van Staa H.G. Leufkens C. Cooper 2002 Does a fracture at one site predict later fractures at other sites? A British cohort study Osteoporos Int 13 624 629 12181620 10.1007/s001980200084 (Pubitemid 34885853)
    • (2002) Osteoporosis International , vol.13 , Issue.8 , pp. 624-629
    • Van Staa, T.P.1    Van Staa, T.P.2    Van Staa, T.P.3    Leufkens, H.G.M.4    Cooper, C.5
  • 24
    • 56749180405 scopus 로고    scopus 로고
    • Strontium ranelate reduces the risk of vertebral fracture in young postmenopausal women with severe osteoporosis
    • 18713788 10.1136/ard.2008.094516 1:STN:280:DC%2BD1cjjsVersw%3D%3D
    • C. Roux J. Fechtenbaum S. Kolta, et al. 2008 Strontium ranelate reduces the risk of vertebral fracture in young postmenopausal women with severe osteoporosis Ann Rheum Dis 67 1736 1738 18713788 10.1136/ard.2008.094516 1:STN:280:DC%2BD1cjjsVersw%3D%3D
    • (2008) Ann Rheum Dis , vol.67 , pp. 1736-1738
    • Roux, C.1    Fechtenbaum, J.2    Kolta, S.3
  • 25
    • 72449194571 scopus 로고    scopus 로고
    • PDotDoEaSAotNS 2008. ##Available at URL.## ##Accessed DATE.## or ##City of Publication: Publisher; Year of Publication.##
    • Author N: 2002 PDotDoEaSAotNS. World population prospects: the 2002 revision and world urban prospects. In; 2008. ##Available at URL.## ##Accessed DATE.## or ##City of Publication: Publisher; Year of Publication.##
    • (2002) World Population Prospects: The 2002 Revision and World Urban Prospects
    • Author, N.1
  • 26
    • 0141993634 scopus 로고    scopus 로고
    • Aging bone and osteoporosis: Strategies for preventing fractures in the elderly
    • DOI 10.1001/archinte.163.18.2237
    • M.P. Ettinger 2003 Aging bone and osteoporosis: strategies for preventing fractures in the elderly Arch Intern Med 163 2237 2246 14557222 10.1001/archinte.163.18.2237 (Pubitemid 37248789)
    • (2003) Archives of Internal Medicine , vol.163 , Issue.18 , pp. 2237-2246
    • Ettinger, M.P.1
  • 30
    • 34848852660 scopus 로고    scopus 로고
    • Strontium ranelate normalizes bone mineral density in osteopenic patients
    • 17726365
    • O. Malaise O. Bruyere J.Y. Reginster 2007 Strontium ranelate normalizes bone mineral density in osteopenic patients Aging Clin Exp Res 19 330 333 17726365
    • (2007) Aging Clin Exp Res , vol.19 , pp. 330-333
    • Malaise, O.1    Bruyere, O.2    Reginster, J.Y.3
  • 32
    • 0141723279 scopus 로고    scopus 로고
    • Strontium ranelate phase 2 dose-ranging studies: PREVOS and STRATOS studies
    • 12730797 1:CAS:528:DC%2BD3sXjslWhs7g%3D
    • J.Y. Reginster P.J. Meunier 2003 Strontium ranelate phase 2 dose-ranging studies: PREVOS and STRATOS studies Osteoporos Int 14 Suppl3 S56 S65 12730797 1:CAS:528:DC%2BD3sXjslWhs7g%3D
    • (2003) Osteoporos Int , vol.14 , Issue.SUPPL3
    • Reginster, J.Y.1    Meunier, P.J.2
  • 33
    • 37749000351 scopus 로고    scopus 로고
    • Relationship between change in femoral neck bone mineral density and hip fracture incidence during treatment with strontium ranelate
    • 17967221 10.1185/030079907X242818 1:CAS:528:DC%2BD1cXhslOksLs%3D
    • O. Bruyere C. Roux J. Badurski, et al. 2007 Relationship between change in femoral neck bone mineral density and hip fracture incidence during treatment with strontium ranelate Curr Med Res Opin 23 3041 3045 17967221 10.1185/030079907X242818 1:CAS:528:DC%2BD1cXhslOksLs%3D
    • (2007) Curr Med Res Opin , vol.23 , pp. 3041-3045
    • Bruyere, O.1    Roux, C.2    Badurski, J.3
  • 35
    • 0035668784 scopus 로고    scopus 로고
    • Development and validation of a specific quality of life module in post-menopausal women with osteoporosis: The QUALIOST™
    • DOI 10.1023/A:1013041206433
    • P. Marquis P. Cialdella C. De la Loge 2001 Development and validation of a specific quality of life module in post-menopausal women with osteoporosis: the QUALIOST Qual Life Res 10 555 566 11789555 10.1023/A:1013041206433 1:STN:280:DC%2BD38%2FmtlKrtA%3D%3D (Pubitemid 34015512)
    • (2001) Quality of Life Research , vol.10 , Issue.6 , pp. 555-566
    • Marquis, P.1    Cialdella, P.2    De La Loge, C.3
  • 36
    • 47249093704 scopus 로고    scopus 로고
    • Strontium ranelate prevents quality of life imparment in post-menopausal women with established vertebral osteoporosis
    • 17929073 10.1007/s00198-007-0464-3 1:CAS:528:DC%2BD1cXkslOksL0%3D
    • P. Marquis C. Roux C. De la Loge, et al. 2008 Strontium ranelate prevents quality of life imparment in post-menopausal women with established vertebral osteoporosis Osteoporos Int 19 503 510 17929073 10.1007/s00198-007-0464-3 1:CAS:528:DC%2BD1cXkslOksL0%3D
    • (2008) Osteoporos Int , vol.19 , pp. 503-510
    • Marquis, P.1    Roux, C.2    De La Loge, C.3
  • 37
    • 85003386622 scopus 로고    scopus 로고
    • Calcium supplementation on bone loss in postmenopausal women
    • CD004526
    • Shea B, Wells G, Cranney A, et al.: Calcium supplementation on bone loss in postmenopausal women. Cochrane Database Syst Rev 2004:CD004526.
    • (2004) Cochrane Database Syst Rev
    • Shea, B.1    Wells, G.2    Cranney, A.3
  • 38
    • 72449166751 scopus 로고    scopus 로고
    • EMEA) EMA. Question and answers on the safety of Protelos/Osseor (strontium ranelate). In; 2007
    • (EMEA) EMA. Question and answers on the safety of Protelos/Osseor (strontium ranelate). In; 2007.
  • 39
    • 55149085956 scopus 로고    scopus 로고
    • Post-marketing assessment of the safety of strontium ranelate; A novel case-only approach to the early detection of adverse drug reactions
    • 18754840 1:CAS:528:DC%2BD1cXhsVyntb7M
    • A. Grosso I. Douglas A. Hingorani, et al. 2008 Post-marketing assessment of the safety of strontium ranelate; a novel case-only approach to the early detection of adverse drug reactions Br J Clin Pharmacol 66 689 694 18754840 1:CAS:528:DC%2BD1cXhsVyntb7M
    • (2008) Br J Clin Pharmacol , vol.66 , pp. 689-694
    • Grosso, A.1    Douglas, I.2    Hingorani, A.3
  • 40
    • 0037640922 scopus 로고    scopus 로고
    • Management of drug rash with eosinophilia and systemic symptoms (DRESS syndrome): An update
    • DOI 10.1159/000069956
    • S. Tas T. Simonart 2003 Management of drug rash with eosinophilia and systemic symptoms (DRESS syndrome): an update Dermatology 206 353 356 12771485 10.1159/000069956 1:STN:280:DC%2BD3s3kslCmuw%3D%3D (Pubitemid 36677029)
    • (2003) Dermatology , vol.206 , Issue.4 , pp. 353-356
    • Tas, S.1    Simonart, T.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.