A retrospective study on the efficacy of total absorbed orbital doses of 12, 16 and 20 Gy combined with systemic steroid treatment in patients with Graves' orbitopathy

Graefe's Archive for Clinical and Experimental Ophthalmology

Volumn 248, Issue 1, 2010, Pages 103-109

  Johnson, Kristian T M ^a   Wittig, Andrea ^a   Loesch, Christian ^a   Esser, Joachim ^a   Sauerwein, Werner ^a   Eckstein, Anja K ^a  

^a UNIVERSITY HOSPITAL ESSEN   (Germany)

Author keywords

Combined treatment; Dose effect; Graves' disease; Orbital irradiation; Steroid treatment

Indexed keywords

FLUOCORTOLONE; PREDNISOLONE HEMISUCCINATE;

ADULT; ARTICLE; CLINICAL ASSESSMENT; CONTROLLED STUDY; DISEASE DURATION; DISEASE SEVERITY; DRUG DOSE REDUCTION; ENDOCRINE OPHTHALMOPATHY; EXOPHTHALMOS; EYE MOVEMENT; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RADIATION DOSE; RADIOTHERAPY; RETROSPECTIVE STUDY; SMOKING; STEROID THERAPY; TREATMENT RESPONSE;

ADOLESCENT; ADULT; AGED; COMBINED MODALITY THERAPY; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLUOCORTOLONE; GLUCOCORTICOIDS; GRAVES DISEASE; HUMANS; IMMUNOGLOBULINS, THYROID-STIMULATING; MALE; MIDDLE AGED; ORBITAL DISEASES; PREDNISOLONE; RADIATION MONITORING; RADIOTHERAPY DOSAGE; RETROSPECTIVE STUDIES; THYROTROPIN; THYROXINE; TREATMENT OUTCOME;

EID: 72449174719     PISSN: 0721832X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00417-009-1214-3     Document Type: Article

References (27)

1. AP Weetman 2003 Autoimmune thyroid disease: propagation and progression Eur J Endocrinol 148 1 9 10.1530/eje.0.1480001 1:CAS:528:DC%2BD3sXptVKntw%3D%3D 12534350 (Pubitemid 36175997)
2. TJ Smith 2005 Insights into the role of fibroblasts in human autoimmune diseases Clin Exp Immunol 141 388 397 10.1111/j.1365-2249.2005.02824.x 1:CAS:528:DC%2BD2MXps1Chs70%3D 16045727 (Pubitemid 41075861)
3. M Ludgate G Baker 2004 Inducing Graves' ophthalmopathy J Endocrinol Invest 27 211 215 1:STN:280:DC%2BD2c3ms1KnsA%3D%3D 15164995
4. L Bartalena L Baldeschi A Dickinson A Eckstein P Kendall-Taylor C Marcocci M Mourits P Perros K Boboridis A Boschi N Curro C Daumerie GJ Kahaly GE Krassas CM Lane JH Lazarus M Marino M Nardi C Neoh J Orgiazzi S Pearce A Pinchera S Pitz M Salvi P Sivelli M Stahl G von Arx WM Wiersinga 2008 Consensus statement of the European Group on Graves' orbitopathy (EUGOGO) on management of GO Eur J Endocrinol 158 273 285 10.1530/EJE-07-0666 1:CAS:528: DC%2BD1cXjsFyltLc%3D 18299459
5. EA Bradley EW Gower DJ Bradley DR Meyer KV Cahill PL Custer DE Holck JJ Woog 2008 Orbital radiation for graves ophthalmopathy: a report by the American Academy of Ophthalmology Ophthalmology 115 398 409 10.1016/j.ophtha.2007.10.028 18082885
6. L Bartalena C Marcocci ML Tanda E Piantanida A Lai M Marino A Pinchera 2005 An update on medical management of Graves' ophthalmopathy J Endocrinol Invest 28 469 478 1:STN:280:DC%2BD2Mvht1agsw%3D%3D 16075933
7. GJ Kahaly HP Rosler S Pitz G Hommel 2000 Low- versus high-dose radiotherapy for Graves' ophthalmopathy: a randomized, single blind trial J Clin Endocrinol Metab 85 102 108 10.1210/jc.85.1.102 1:CAS:528: DC%2BD3cXjtl2hsQ%3D%3D 10634372 (Pubitemid 32268798)
8. JP Pierce MM White K Messer 2009 Changing age-specific patterns of cigarette consumption in the United States, 1992-2002: Association with smoke-free homes and state-level tobacco control activity Nicotine Tob Res 11 171 177 10.1093/ntr/ntp014 19246423
9. Eckstein AK, Plicht M, Lax H, Neuhauser M, Mann K, Lederbogen S, Heckmann C, Esser J and Morgenthaler NG (2006) TSH-receptor autoantibodies are independent risk factors for Graves' ophthalmopathy and help to predict severity and outcome of the disease*. J Clin Endocrinol Metab
10. MP Mourits MF Prummel WM Wiersinga L Koornneef 1997 Clinical activity score as a guide in the management of patients with Graves' ophthalmopathy Clin Endocrinol (Oxf) 47 9 14 10.1046/j.1365-2265.1997.2331047.x 1:STN:280: DyaK2svksl2htg%3D%3D
11. AK Eckstein A Finkenrath A Heiligenhaus K Renzing-Kohler J Esser C Kruger B Quadbeck KP Steuhl RK Gieseler 2004 Dry eye syndrome in thyroid-associated ophthalmopathy: lacrimal expression of TSH receptor suggests involvement of TSHR-specific autoantibodies Acta Ophthalmol Scand 82 291 297 10.1111/j.1395-3907.2004.00268.x 1:CAS:528:DC%2BD2cXltFyjtLw%3D 15115450
12. S Costagliola NG Morgenthaler R Hoermann K Badenhoop J Struck D Freitag S Poertl W Weglohner JM Hollidt B Quadbeck JE Dumont PM Schumm-Draeger A Bergmann K Mann G Vassart KH Usadel 1999 Second generation assay for thyrotropin receptor antibodies has superior diagnostic sensitivity for Graves' disease J Clin Endocrinol Metab 84 90 97 10.1210/jc.84.1.90 1:CAS:528:DyaK1MXmslWmtw%3D%3D 9920067 (Pubitemid 29036685)
13. R Heyd MH Seegenschmiedt G Strassmann O Micke HB Makoski N Zamboglou 2003 Radiotherapy for Graves' orbitopathy: results of a national survey Strahlenther Onkol 179 372 376 12789462
14. L Bartalena C Marcocci ML Tanda R Rocchi B Mazzi G Barbesino A Pinchera 2002 Orbital radiotherapy for Graves' ophthalmopathy Thyroid 12 245 250 10.1089/105072502753600223 11952048
15. H Nakahara S Noguchi N Murakami M Morita M Tamaru T Ohnishi H Hoshi S Jinnouchi S Nagamachi S Futami, et al. 1995 Graves ophthalmopathy: MR evaluation of 10-Gy versus 24-Gy irradiation combined with systemic corticosteroids Radiology 196 857 862 1:CAS:528:DyaK2MXpsVWmsLg%3D 7644656
16. MF Prummel CB Terwee MN Gerding L Baldeschi MP Mourits L Blank FW Dekker WM Wiersinga 2004 A randomized controlled trial of orbital radiotherapy versus sham irradiation in patients with Mild Graves' ophthalmopathy J Clin Endocrinol Metab 89 15 20 10.1210/jc.2003-030809 1:CAS:528:DC%2BD2cXmvFeltA%3D%3D 14715820 (Pubitemid 38183852)
17. MF Prummel MP Mourits L Blank A Berghout L Koornneef WM Wiersinga 1993 Randomized double-blind trial of prednisone versus radiotherapy in Graves' ophthalmopathy Lancet 342 949 954 10.1016/0140-6736(93)92001-A 1:STN:280:DyaK2c%2FhvVWmsQ%3D%3D 8105213 (Pubitemid 23305498)
18. MP Mourits ML van Kempen-Harteveld MB Garcia HP Koppeschaar L Tick CB Terwee 2000 Radiotherapy for Graves' orbitopathy: randomised placebo-controlled study Lancet 355 1505 1509 10.1016/S0140-6736(00)02165-6 1:STN:280: DC%2BD3c3lvFWisg%3D%3D 10801172
19. C Marcocci L Bartalena F Bogazzi G Bruno-Bossio A Lepri A Pinchera 1991 Orbital radiotherapy combined with high dose systemic glucocorticoids for Graves' ophthalmopathy is more effective than radiotherapy alone: results of a prospective randomized study J Endocrinol Invest 14 853 860 1:STN:280: DyaK383gt1Kiug%3D%3D 1802923
20. C Marcocci L Bartalena ML Tanda L Manetti E Dell'Unto R Rocchi G Barbesino B Mazzi MP Bartolomei P Lepri F Cartei M Nardi A Pinchera 2001 Comparison of the effectiveness and tolerability of intravenous or oral glucocorticoids associated with orbital radiotherapy in the management of severe Graves' ophthalmopathy: results of a prospective, single-blind, randomized study J Clin Endocrinol Metab 86 3562 3567 10.1210/jc.86.8.3562 1:CAS:528:DC%2BD3MXlvFektrk%3D 11502779 (Pubitemid 32755944)
21. L Bartalena C Marcocci L Chiovato M Laddaga G Lepri D Andreani G Cavallacci L Baschieri A Pinchera 1983 Orbital cobalt irradiation combined with systemic corticosteroids for Graves' ophthalmopathy: comparison with systemic corticosteroids alone J Clin Endocrinol Metab 56 1139 1144 10.1210/jcem-56-6- 1139 1:STN:280:DyaL3s7os1Kksw%3D%3D 6341388
22. CM Ng HK Yuen KL Choi MK Chan KT Yuen YW Ng SC Tiu 2005 Combined orbital irradiation and systemic steroids compared with systemic steroids alone in the management of moderate-to-severe Graves' ophthalmopathy: a preliminary study Hong Kong Med J 11 322 330 1:STN:280:DC%2BD2MrktlGrtA%3D%3D 16219950
23. Kahaly GJ (2007) Management of moderately severe Graves' orbitopathy. In: Wiersinga WM, Kahaly GJ (eds) Graves' orbitopathy: A multidisciplinary approach. Karger, Basel, pp 120-152
24. R Bahn 2008 The EUGOGO consensus statement on the management of Graves' orbitopathy: equally applicable to North American clinicians and patients Thyroid 18 281 282 10.1089/thy.2008.0034 18341375
25. F Rodel F Kamprad R Sauer G Hildebrandt 2002 Functional and molecular aspects of anti-inflammatory effects of low-dose radiotherapy Strahlenther Onkol 178 1 9 10.1007/s00066-002-0901-3 11977385 (Pubitemid 34074214)
26. D Schaue J Jahns G Hildebrandt KR Trott 2005 Radiation treatment of acute inflammation in mice Int J Radiat Biol 81 657 667 10.1080/09553000500385556 1:CAS:528:DC%2BD2MXhtlaktL%2FI 16368644 (Pubitemid 43169757)
27. A Pappa P Jackson J Stone P Munro P Fells C Pennock S Lightman 1998 An ultrastructural and systemic analysis of glycosaminoglycans in thyroid-associated ophthalmopathy Eye 12 Pt 2 237 244 9683947