A Randomized Controlled Trial of Orbital Radiotherapy Versus Sham Irradiation in Patients with Mild Graves' Ophthalmopathy

Journal of Clinical Endocrinology and Metabolism

Volumn 89, Issue 1, 2004, Pages 15-20

  Prummel, Mark F ^a   Terwee, Caroline B ^a   Gerding, Martin N ^a   Baldeschi, Lelio ^a   Mourits, Maarten P ^b   Blank, Leo ^a   Dekker, Friedo W ^a   Wiersinga, Wilmar M ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONFIDENCE INTERVAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; COST EFFECTIVENESS ANALYSIS; DIPLOPIA; ENDOCRINE OPHTHALMOPATHY; EXTRAOCULAR MUSCLE; EYE MOVEMENT CONTROL; FEMALE; FOLLOW UP; HEALTH CARE COST; HUMAN; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; MALE; ORBITAL RADIOTHERAPY; PARTIAL BODY RADIATION; PRIORITY JOURNAL; QUALITY OF LIFE; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; STATISTICAL SIGNIFICANCE; TREATMENT OUTCOME;

COSTS AND COST ANALYSIS; DOUBLE-BLIND METHOD; EYE DISEASES; EYE MOVEMENTS; GRAVES DISEASE; ORBIT; QUALITY OF LIFE; QUESTIONNAIRES; RADIOTHERAPY; TREATMENT OUTCOME;

EID: 0842291523     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2003-030809     Document Type: Article

References (41)

1. Weetman AP, Wiersinga WM 1998 Current management of thyroid-associated ophthalmopathy in Europe. Results of an international survey. Clin Endocrinol (Oxf) 49:21-28
2. Bartalena L, Pinchera A, Marcocci C 2000 Management of Graves' ophthalmopathy: reality and perspectives. Endocr Rev 21:168-199
3. Bartalena L, Marcocci C, Tanda ML, Rocchi R, Mazzi B, Barbesino G, Pinchera A 2002 Orbital radiotherapy for Graves' ophthalmopathy. Thyroid 12: 245-250
4. Burch HB, Wartofsky L 1993 Graves' ophthalmopathy: current concepts regarding pathogenesis and management. Endocr Rev 14:747-793
5. Prummel MF, Mourits MP, Blank L, Berghout A, Koornneef L, Wiersinga WM 1993 Randomized double-blind trial of prednisone versus radiotherapy in Graves' ophthalmopathy. Lancet 342:949-954
6. Bartalena L, Marcocci C, Chiovato L, Laddaga M, Lepri C, Andreani D, Cavallacci G, Baschieri L, Pinchera A 1983 Orbital cobalt irradiation combined with systemic corticosteroids for Graves' ophthalmopathy: comparison with systemic corticosteroids alone. J Clin Endocrinol Metab 56:1139-1144
7. Marcocci C, Bartalena L, Bogazzi F, Bruno-Bossio G, Lepri A, Pinchera A 1991 Orbital radiotherapy combined with high dose systemic glucocorticoids for Graves' ophthalmopathy is more effective than radiotherapy alone: results of a prospective randomized study. J Endocrinol Invest 14:853-860
8. Mourits MP, Kempen-Harteveld ML, Garcia MB, Koppeschaar HP, Tick L, Terwee CB 2000 Radiotherapy for Graves' orbitopathy: randomised placebo-controlled study. Lancet 355:1505-1509
9. Gorman CA, Garrity JA, Fatourechi V, Bahn RS, Petersen IA, Stafford SL, Earle JD, Forbes GS, Kline RW, Bergstralh EJ, Offord KP, Rademacher DM, Stanley NM, Bartley GB 2001 A prospective, randomized, double-blind, placebo-controlled study of orbital radiotherapy for Graves' ophthalmopathy. Ophthalmology 108:1523-1534
10. Bartalena L, Marcocci C, Gorman CA, Wiersinga WM, Pinchera A 2003 Orbital radiotherapy for Graves' ophthalmopathy: useful or useless? Safe or dangerous? J Endocrinol Invest 26:5-16
11. Wiersinga WM 2002 Perspective. III. Retrobulbar irradiation in Graves orbitopathy: the Dutch experience. Ophthal Plast Reconstr Surg 18:175-176
12. Kazim M 2002 Perspective. II. Radiotherapy for Graves Orbitopathy: the Columbia University experience. Ophthal Plast Reconstr Surg 18:173-174
13. Bartley GB, Gorman CA 2002 Perspective. I. the Mayo Orbital Radiotherapy for Graves Ophthalmopathy (ORGO) study: lessons learned. Ophthal Plast Reconstr Surg 18:170-172
14. Bartalena L 2003 Orbital radiation therapy for Graves' ophthalmopathy. Ophthalmology 110:452-453
15. Steinsapir KD, Goldberg RA 2003 Orbital radiation therapy for Graves' ophthalmopathy. Ophthalmology 110:451-452
16. Haddad HM 2003 Orbital radiation therapy for Graves' ophthalmopathy. Ophthalmology 110:450
17. Meyer DR 2003 Orbital radiation therapy for Graves' ophthalmopathy. Ophthalmology 110:450-451
18. Ainbinder DJ, Halligan JB 2003 Orbital radiation therapy for Graves' ophthalmopathy. Ophthalmology 110:449-450
19. Feldon SE 2001 Radiation therapy for Graves' ophthalmopathy: trick or treat? Ophthalmology 108:1521-1522
20. Wiersinga WM, Prummel MF 2000 An evidence-based approach to the treatment of Graves' ophthalmopathy. Endocrinol Metab Clin North Am 29:297-319
21. Terwee CB, Gerding MN, Dekker FW, Prummel MF, Wiersinga WM 1998 Development of a disease specific quality of life questionnaire for patients with Graves' ophthalmopathy: the GO-QOL. Br J Ophthalmol 82:773-779
22. Terwee CB, Gerding MN, Dekker FW, Prummel MF, van der Pol JP, Wiersinga WM 1999 Test-retest reliability of the GO-QOL: a disease-specific quality of life questionnaire for patients with Graves' ophthalmopathy. J Clin Epidemiol 52:875-884
23. Anonymous 1992 Classification of eye changes of Graves' disease. Thyroid 2:235-236
24. Brokken LJ, Scheenhart JW, Wiersinga WM, Prummel MF 2001 Suppression of serum TSH by Graves' Ig: evidence for a functional pituitary TSH receptor. J Clin Endocrinol Metab 86:4814-4817
25. Mourits MP, Prummel MF, Wiersinga WM, Koornneef L 1994 Measuring eye movements in Graves ophthalmopathy. Ophthalmology 101:1341-1346
26. Gerding MN, Prummel MF, Kalmann R, Koornneef L, Wiersinga WM 1998 The use of colour slides in the assessment of changes in soft-tissue involvement in Graves' ophthalmopathy. J Endocrinol Invest 21:459-462
27. Bahn RS, Gorman CA 1987 Choice of therapy and criteria for assessing treatment outcome in thyroid-associated ophthalmopathy. Endocrinol Metab Clin North Am 16:391-407
28. Duke-Elder SSR 1962 The examination of the visual functions. In: Duke-Elder S, ed. The foundations of ophthalmology: hereditary, pathology, diagnosis, and therapeutics. System of ophthalmology. St. Louis: Mosby; vol 7:370-373
29. Mourits MP, Prummel MF, Wiersinga WM, Koornneef L 1997 Clinical activity score as a guide in the management of patients with Graves' ophthalmopathy. Clin Endocrinol (Oxf) 47:9-14
30. Mourits MP, Koornneef L, Wiersinga WM, Prummel MF, Berghout A, Van der GR 1989 Clinical criteria for the assessment of disease activity in Graves' ophthalmopathy: a novel approach. Br J Ophthalmol 73:639-644
31. Bartalena L, Marcocci C, Bogazzi F, Manetti L, Tanda ML, Dell'Unto E, Bruno-Bossio G, Nardi M, Bartolomei MP, Lepri A, Rossi G, Martino E, Pinchera A 1998 Relation between therapy for hyperthyroid ism and the course of Graves' ophthalmopathy. N Engl J Med 338:73-78
32. Terwee CB, Dekker FW, Mourits MP, Gerding MN, Baldeschi L, Kalmann R, Prummel MF, Wiersinga WM 2001 Interpretation and validity of changes in scores on the Graves' ophthalmopathy quality of life questionnaire (GO-QOL) after different treatments. Clin Endocrinol (Oxf) 54:391-398
33. Stewart AL, Hays RD, Ware Jr JE 1988 The MOS short-form general health survey. Reliability and validity in a patient population. Med Care 26:724-735
34. Kempen GI 1992 Assessment of health status of the elderly. Application of a Dutch version of the MOS scale. Tijdschr Gerontol Geriatr 23:132-140
35. Bergner M, Bobbitt RA, Kressel S, Pollard WE, Gilson BS, Morris JR 1976 The sickness impact profile: conceptual formulation and methodology for the development of a health status measure. Int J Health Serv 6:393-415
36. EuroQoL Group 1990 EuroQoL: a new facility for the measurement of health-related quality of life. Health Policy 16:199-208
37. Drummond MF 1987 Economic evaluation and the rational diffusion and use of health technology. Health Policy 7:309-324
38. Oostenbrink J, Koopmanschap MA, Rutten FFH 2000 Handleiding voor kostenonderzoek. Rotterdam/Amstelveen: IMTA/CVZ
39. Steinsapir KD, Goldberg RA 2003 Orbital radiation therapy for Graves' ophthalmopathy. Ophthalmology 110:451-452
40. Kahaly GJ, Rosler HP, Pitz S, Hommel G 2000 Low-versus high-dose radiotherapy for Graves' ophthalmopathy: a randomized, single blind trial. J Clin Endocrinol Metab 85:102-108
41. Perros P, Crombie AL, Kendall-Taylor P 1995 Natural history of thyroid associated ophthalmopathy. Clin Endocrinol (Oxf) 42:45-50