RB has a critical role in mediating the in vivo checkpoint response, mitigating secondary DNA damage and suppressing liver tumorigenesis initiated by aflatoxin B1

Oncogene

Volumn 28, Issue 50, 2009, Pages 4434-4443

  Reed, C A ^a   Mayhew, C N ^b   McClendon, A K ^a   Yang, X ^a   Witkiewicz, A ^c   Knudsen, E S ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b CINCINNATI CHILDREN S HOSPITAL RESEARCH FOUNDATION   (United States)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Aflatoxin B1; Carbon tetrachloride; Cell cycle; DNA damage; Hepatocellular carcinoma; Retinoblastoma tumor suppressor

Indexed keywords

AFLATOXIN B1; CYCLIN D1; LAMININ GAMMA1; RETINOBLASTOMA PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER SUSCEPTIBILITY; CELL CYCLE REGULATION; CONTROLLED STUDY; DNA DAMAGE; DOUBLE STRANDED DNA BREAK; FEMALE; GENE DELETION; GENOMIC INSTABILITY; GENOTOXICITY; IN VIVO STUDY; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; LIVER REGENERATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION;

AFLATOXIN B1; ANIMALS; ANIMALS, NEWBORN; CELL CYCLE; CYCLIN D1; DNA DAMAGE; E2F1 TRANSCRIPTION FACTOR; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; LIVER REGENERATION; MICE; MITOSIS; RETINOBLASTOMA PROTEIN;

EID: 72449154569     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2009.303     Document Type: Article

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