Synthesis of thieno[2,3-d]oxazines and thieno[2,3-d]thiazines as subtype specific kainate receptor antagonists

Current Medicinal Chemistry

Volumn 16, Issue 35, 2009, Pages 4704-4711

  Briel, D ^a   Rybak, A ^a   Mann, S ^a   Kronbach, C ^b   Unverferth, K ^b  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b Elbion AG   (Germany)

Author keywords

Anticonvulsives; Glutamate receptor antagonists; Kainate receptor antagonists; Thieno 2,3 d pyrimidines; Thieno 2,3 d 1.3 oxazines; Thieno 2,3 d 1.3 thiazines

Indexed keywords

2 AMINO 4 METHYL 5 PHENYLTHIOPHENE 3 CARBOXYLIC ACID; 2 AMINO 4,5,6,7 TETRAHYDROBENZO[B]THIOPHENE 3 CARBOXYLIC ACID; 2 AMINO 5 PHENYLTHIOPHENE 3 CARBOXYLIC ACID; 2 AMINO 6 PHENYL 4,5,6,7 TETRAHYDROBENZO[B]THIOPHENE 3 CARBOXYLIC ACID; 2 AMINOTHIOPHENE 3 CARBOXYLIC ACID ETHYLESTER; 2 BUT 1 YL 5 METHYL 6 PHENYLTHIENO[2,3 D][1,3]OXAZINE 4 ONE; 2 ISOPROPYL 5 METHYL 6 PHENYLTHIENO[2,3 D][1,3]OXAZINE 4 ONE; 2 METHYL 6 PHENYLTHIENO[2,3 D][1,3]OXAZINE 4 ONE; 2 TRIFLUORMETHYL 5 METHYL 6 PHENYLTHIENO[2,3 D][1,3]OXAZINE 4 ONE; 2,5 DIMETHYL 6 PHENYLTHIENO[2,3 D][1,3]OXAZINE 4 ONE; 5 METHYL 2,6 DIPHENYLTHIENO[2,3 D][1,3]OXAZINE 4 ONE; 5 METHYL 4 OXO 6 PHENYL 4H THIENO[2,3 D][1,3]OXAZINE 4 ONE; 5 METHYL 6 PHENYL 2 PROP 1 YLTHIENO[2,3 D][1,3]OXAZINE 4 ONE; 5 METHYL 6 PHENYL 2 TRICHLORMETHYLTHIENO[2,3 D][1,3]OXAZINE 4 ONE; 5 METHYL 6 PHENYLTHIENO[2,3 D][1,3]OXAZINE 4 ONE; 5,6,7,8 TETRAHYDROBENZO[4,5]THIENO[2,3 D][1,3]OXAZINE 4 ONE; ANTICONVULSIVE AGENT; CHINAZOLINE DERIVATIVE; GLUTAMATE RECEPTOR 5; GLUTAMATE RECEPTOR 6; GLUTAMATE RECEPTOR ANTAGONIST; IONOTROPIC RECEPTOR ANTAGONIST; KAINIC ACID RECEPTOR; KAINIC ACID RECEPTOR ANTAGONIST; THIENO[2,3 D][1,3]OXAZINE 4 ONE DERIVATIVE; THIENO[2,3 D][1,3]THIAZINE DERIVATIVE; THIENO[2,3 D]OXAZINE DERIVATIVE; THIENO[2,3 D]PYRIMIDINE DERIVATIVE; THIENO[2,3 D]THIAZINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTICONVULSANT ACTIVITY; ARTICLE; DRUG SYNTHESIS; DRUG TARGETING; HUMAN; IC 50; RECEPTOR BLOCKING;

ANTICONVULSANTS; CELL LINE; HUMANS; OXAZINES; PYRIMIDINES; RECEPTORS, KAINIC ACID; THIAZINES;

EID: 72449153981     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/092986709789878283     Document Type: Article

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