Nicotine-induced CCN2: From smoking to periodontal fibrosis

Journal of Dental Research

Volumn 89, Issue 1, 2010, Pages 34-39

  Takeuchi, H ^a   Kubota, S ^b   Murakashi, E ^a   Zhou, Y ^b   Endo, K ^c   Ng, P S ^c   Takigawa, M ^b   Numabe, Y ^a  

^a NIPPON DENTAL UNIVERSITY   (Japan)

^b OKAYAMA UNIVERSITY   (Japan)

^c Nosan Corporation   (Japan)

Author keywords

CTGF; Fibrosis; Gingival.; Nicotine; Smoking

Indexed keywords

COLLAGEN TYPE 1; CONNECTIVE TISSUE GROWTH FACTOR; MESSENGER RNA; NICOTINE; NICOTINIC AGENT;

ADULT; ARTICLE; CASE CONTROL STUDY; CELL CULTURE; CELL DIFFERENTIATION; CHEMICALLY INDUCED DISORDER; COMPARATIVE STUDY; CYTOLOGY; DOSE RESPONSE; DRUG EFFECT; FEMALE; FIBROBLAST; FIBROSIS; GENE EXPRESSION REGULATION; GENETICS; GINGIVA; HUMAN; MALE; METABOLISM; PERIODONTAL LIGAMENT; REFERENCE VALUE; SMOKING; TIME;

ADULT; CASE-CONTROL STUDIES; CELL DIFFERENTIATION; CELLS, CULTURED; COLLAGEN TYPE I; CONNECTIVE TISSUE GROWTH FACTOR; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FIBROBLASTS; FIBROSIS; GENE EXPRESSION REGULATION; GINGIVA; HUMANS; MALE; NICOTINE; NICOTINIC AGONISTS; PERIODONTAL LIGAMENT; REFERENCE VALUES; RNA, MESSENGER; SMOKING; TIME FACTORS; YOUNG ADULT;

EID: 72449142340     PISSN: 00220345     EISSN: 15440591     Source Type: Journal    
DOI: 10.1177/0022034509353403     Document Type: Article

References (22)

1. Abdel Wahab N., Mason RM (2004). Connective tissue growth factor and renal diseases: some answers, more questions. Curr Opin Nephrol Hypertens 13: 53-58.
2. Alexakis C., Maxwell P., Bou-Gharios G. (2006). Organ-specific collagen expression: implications for renal disease. Nephron Exp Nephrol 102: 71-75.
3. Blalock TD, Duncan MR, Varela JC, Goldstein MH, Tuli SS, Grotendorst GR, et al. (2003). Connective tissue growth factor expression and action in human corneal fibroblast cultures and rat corneas after photorefractive keratectomy. Invest Ophthalmol Vis Sci 44: 1879-1887.
4. Brigstock DR, Goldschmeding R., Katsube KI, Lam SC, Lau LF, Lyons K., et al. (2003). Proposal for a unified CCN nomenclature. Mol Pathol 56: 127-128.
5. Calsina G., Ramón JM, Echeverria JJ (2002). Effects of smoking on periodontal tissues. J Clin Periodontol 29: 771-776.
6. Cheng O., Thuillier R., Sampson E., Mannon RB, Shultz G., Ruiz P., et al. (2006). Connective tissue growth factor is a biomarker and mediator of kidney allograft fibrosis. Am J Transplan 6: 2292-2306.
7. Gressner OA, Gressner AM (2008). Connective tissue growth factor: a fibrogenic master switch in fibrotic liver diseases. Liver Int 28: 1065-1079.
8. Heng EC, Huang Y., Black SA Jr, Trackman PC (2006). CCN2, connective tissue growth factor, stimulates collagen deposition by gingival fibroblasts via module 3 and alpha6- and beta1 integrins. J Cell Biochem 15: 409-420.
9. Ikawa Y., Ng PS, Endo K., Kondo M., Chujo S., Takehara K., et al. (2008). Neutralizing monoclonal antibody to human connective tissue growth factor ameliorates transforming growth factor-beta-induced mouse fibrosis. J Cell Physiol 216: 680-687.
10. Ito Y., Aten J., Bende RJ, Oemar BS, Rabelink TJ, Weening JJ, et al. (1998). Expression of connective tissue growth factor in human renal fibrosis. Kidney Int 53: 853-861.
11. Kamma JJ, Giannopoulou C., Vasdekis VG, Mombelli A. (2004). Cytokine profile in gingival crevicular fluid of aggressive periodontitis: influence of smoking and stress. J Clin Periodontol 31: 894-902.
12. Kubota S., Takigawa M. (2007). Role of CCN2/CTGF/Hcs24 in bone growth. Int Rev Cytol 257: 1-41.
13. Lasky JA, Ortiz LA, Tonthat B., Hoyle GW, Corti M., Friedman M., et al. (1998). Connective tissue growth factor mRNA expression is upregulated in bleomycin-induced lung fibrosis. Am J Physiol 275 (2 Pt 1). 365-371.
14. Leask A. (2004). Transcriptional profiling of the scleroderma fibroblast reveals a potential role for connective tissue growth factor (CTGF) in pathological fibrosis. Keio J Med 53: 74-77.
15. Makino A., Yamada S., Okuda K., Kato T. (2008). Nicotine involved in periodontal disease through influence on cytokine levels. FEMS Immunol Med Microbiol 52: 282-286.
16. Perbal B. (2004). CCN proteins: multifunctional signalling regulators. Lancet 363: 62-64.
17. Sato E., Hashimoto H., Kamoi H., Tachibana T., Ishikawa H., Kamoi K. (2005). Proliferation and tube formation of periodontal endothelial cells. Hum Cell 18: 83-91.
18. Takeuchi H., Kubota S., Murakashi E., Fukada T., Takigawa M., Numabe Y., et al. (2009). Effect of TGF-21 on CCN2/CTGF in normal human gingival fibroblasts and periodontal ligament cells. J Periodontal Res 4: 161-169.
19. Takigawa M., Nishida T., Kubota S. (2005). Roles of CCN2/CTGF in the control of growth and regeneration. In: CCN proteins: a new family of cell growth and differentiation regulators. Perbal B, Takigawa M, editors. London, UK: Imperial College Press, pp. 19-59.
20. Vial WC (1986). Cigarette smoking and lung disease. Am J Med Sci 291: 130-142.
21. Wanner A. (1985). A review of the effects of cigarette smoke on airway mucosal function. Eur J Respir Dis Suppl 139: 49-53.
22. Wynn TA (2008). Cellular and molecular mechanisms of fibrosis. J Pathol 214: 199-210.