Melatonin decreases daytime challenging behaviour in persons with intellectual disability and chronic insomnia

Journal of Intellectual Disability Research

Volumn 54, Issue 1, 2010, Pages 52-59

  Braam, W ^a,b,c   Didden, R ^b,d,e   Maas, A P H M ^c,f   Korzilius, H ^d   Smits, M G ^b,c   Curfs, L M G ^c  

^a 'S Heeren Loo Zuid Veluwe ^*  (Netherlands)

^b GELDERSE VALLEI HOSPITAL   (Netherlands)

^c MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^d RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^e Trajectum   (Netherlands)

^f MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

Challenging behaviour; Dim light melatonin onset; Insomnia; Intellectual disability; Melatonin

Indexed keywords

MELATONIN; PLACEBO;

ADOLESCENT; ADULT; AGED; ARTICLE; BEHAVIOR DISORDER; CHILD; CIRCADIAN RHYTHM; CLINICAL ASSESSMENT TOOL; CLINICAL TRIAL; FEMALE; HUMAN; INSOMNIA; INTELLECTUAL IMPAIRMENT; LATENT PERIOD; LIGHT; MAJOR CLINICAL STUDY; MALADAPTIVE BEHAVIOR SCALE FOR MENTALLY RETARDED; MALE; SALIVA ANALYSIS; SLEEP INDUCTION; SLEEP STAGE; SLEEP TIME; VERBAL HOSTILITY;

ADOLESCENT; ADULT; CHILD; CHILD, PRESCHOOL; CHRONIC DISEASE; CIRCADIAN RHYTHM; FEMALE; HUMANS; MALE; MELATONIN; MENTAL RETARDATION; MIDDLE AGED; RANDOMIZED CONTROLLED TRIALS AS TOPIC; SLEEP; SLEEP INITIATION AND MAINTENANCE DISORDERS; SOCIAL BEHAVIOR DISORDERS; WAKEFULNESS;

EID: 72449123204     PISSN: 09642633     EISSN: 13652788     Source Type: Journal    
DOI: 10.1111/j.1365-2788.2009.01223.x     Document Type: Article

References (31)

1. Ancoli-Israel S, Cole R, Alessi C, Chambers M, Moorcroft W, Pollak C P. The role of actigraphy in the study of sleep and circadian rhythms. Sleep 2003, 26:342-92.
2. Braam W, Didden R, Smits M, Curfs L. Melatonin treatment in individuals with intellectual disability and chronic insomnia: a randomized placebo-controlled study. Journal of Intellectual Disability Research 2008a, 52:256-64.
3. Braam W, Didden R, Smits M G, Curfs L M. Melatonin for chronic insomnia in Angelman syndrome: a randomized placebo-controlled trial. Journal of Child Neurology 2008b, 23:649-54.
4. Braam W, Smits M G, Didden R, Korzilius H, Van Geijlswijk I M, Curfs L M G. Exogenous melatonin for sleep problems in individuals with intellectual disability: a meta-analysis. Developmental Medicine & Child Neurology 2009, 51:340-9.
5. Carr R, Wasdell M B, Hamilton D, Weiss M D, Freeman R D, Tai J. Long-term effectiveness of melatonin therapy in children with treatment-resistant circadian rhythm sleep disorders. Journal of Pineal Research 2007, 43:351-9.
6. Chadwick O, Piroth N, Walker J, Bernard S, Taylor E. Factors affecting the risk of behaviour problems in children with severe intellectual disability. Journal of Intellectual Disability Research 2000, 44:108-23.
7. 1997, Committee for Proprietary Medicinal Products, Note for guidance on clinical investigation of medicinal products in children, CPMP/EWP/462/95 London, ICH
8. Coppola G, Iervolino G, Mastrosimone M, La Torre G, Ruiu F, Pascotto A. Melatonin in wake-sleep disorders in children, adolescents and young adults with mental retardation with or without epilepsy: a double-blind, cross-over, placebo-controlled trial. Brain & Development 2004, 26:373-6.
9. Dahlitz M, Alvarez B, Vignau J, English J, Arendt J, Parkes J. Delayed sleep phase syndrome response to melatonin. The Lancet 1991, 337:1121-4.
10. Didden R, Sigafoos J. A review of the nature and treatment of sleep disorders in individuals with developmental disabilities. Research in Developmental Disabilities 2001, 22:255-72.
11. Didden R, Korzilius H, Van Aperlo B, Van Overloop C, De Vries M. Sleep problems and daytime problem behaviours in children with intellectual disability. Journal of Intellectual Disability Research 2002, 46:537-47.
12. Evers A. Improving test quality in the Netherlands: results of 18 years of test ratings. International Journal of Testing 2001, 1:137-53.
13. Ivanenko A, McLaughlin Crabtree V, Tauman R, Gozal D. Melatonin in children and adolescents with insomnia: a retrospective study. Clinical Pediatrics 2003, 42:51-8.
14. Jan M M S. Melatonin for the treatment of handicapped children with severe sleep disorders. Pediatric Neurology 2000, 23:229-32.
15. Jan J E, Freeman R D. Melatonin therapy for circadian rhythm sleep disorders in children with multiple disabilities: what have we learned in the last decade. Developmental Medicine & Child Neurology 2004, 46:776-82.
16. Jan J E, Espezel H, Appleton R E. The treatment of sleep disorders with melatonin. Developmental Medicine & Child Neurology 1994, 36:97-107.
17. Kraijer D W, Kema G N. SGZ, Storend Gedragsschaal Voor Zwakzinnigen. Handleiding (Maladaptive Behaviour Scale for the Mentally Retarded) 1994, 5th, edn, Swets & Zeitlinger, Lisse
18. Leibenluft E. The rhythm of the blues. The American Journal of Psychiatry 2008, 165:1501-4.
19. Lewy A J, Sack R L. The dim light melatonin onset as a marker for circadian phase position. Chronobiology International 1989, 6:93-102.
20. Lewy A J, Cutler N L, Sack R L. The endogenous melatonin profile as a marker for circadian phase position. Journal of Biological Rhythms 1999, 14:227-36.
21. Nagtegaal J, Kerkhof G, Smits M, Swart A, Van der Meer Y. Delayed sleep phase syndrome: a placebo-controlled cross-over study on the effects of melatonin administered five hours before the individual dim light melatonin onset. Journal of Sleep Research 1998, 7:135-43.
22. Pandi-Perumal S R, Smits M, Spence W, Srinivasan V, Cardinali D P, Lowe A D. Dim light melatonin onset (DLMO): a tool for the analysis of circadian phase in human sleep and chronobiological disorders. Progress in Neuro-Psychopharmacology & Iological Psychiatry 2007, 31:1-11.
23. Sadeh A, Lavie P, Scher A, Tirosh E, Epstein R. Actigraphic home-monitoring sleep-disturbed and control infants and young children: a new method for pediatric assessment of sleep-wake patterns. Pediatrics 1991, 87:494-9.
24. Smits M, van Stel H, Nagtegaal J, Van Der Heijden J, Coenen A, Kerkhof G. Melatonin for chronic sleep onset insomnia in children: a randomized placebo-controlled trial. Journal of Child Neurology 2001, 16:86-92.
25. Smits M G, van Stel H F, Van Der Heijden K, Meijer A M, Coenen A M, Kerkhof G A. Melatonin improves health status and sleep in children with idiopathic chronic sleep-onset insomnia: a randomized placebo-controlled trial. Journal of the American Academy of Child and Adolescent Psychiatry 2003, 42:1286-93.
26. Thackeray E J, Richdale A L. The behavioural treatment of sleep difficulties in children with an intellectual disability. Behavioral Interventions 2002, 17:211-31.
27. Van Wieringen S, Jansen T, Smits M, Nagtegaal J, Coenen A. Melatonin for chronic whiplash syndrome with delayed melatonin onset. Randomised, placebo-controlled trial. Clinical Drug Investigation 2001, 21:813-20.
28. Wasdell M B, Jan J E, Bomben M M, Freeman R D, Rietveld W J, Tai J. A randomized, placebo-controlled trial of controlled release melatonin treatment of delayed sleep phase syndrome and impaired sleep maintenance in children with neurodevelopmental disabilities. Journal of Pineal Research 2008, 44:57-64.
29. Wiggs L, Stores G. Severe sleep disturbance and daytime challenging behaviour in children with severe learning disabilities. Journal of Intellectual Disability Research 1996, 40:518-28.
30. Wiggs L, Stores G. Behavioural treatment for sleep problems in children with severe learning disabilities and challenging daytime behaviour: effect on daytime behaviour. Journal of Child Psychology and Psychiatry and Allied Disciplines 1999, 40:627-35.
31. Wirz-Justice A, Armstrong S. Melatonin: nature's soporific? Journal of Sleep Research 1996, 5:137-41.