Serum inflammatory mediators in pregnancy: Changes after periodontal treatment and association with pregnancy outcomes

Journal of Periodontology

Volumn 80, Issue 11, 2009, Pages 1731-1741

  Michalowicz, Bryan S ^a   Novak, M John ^b   Hodges, James S ^c   DiAngelis, Anthony ^d   Buchanan, William ^e   Papapanou, Panos N ^f   Mitchell, Dennis A ^f   Ferguson II, James E ^g   Lupo, Virginia ^d   Bofill, James ^h   Matseoane, Stephen ⁱ   Steffen, Michelle ^b   Ebersole, Jeffrey L ^b  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIVERSITY OF KENTUCKY COLLEGE OF DENTISTRY   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

^d HENNEPIN COUNTY MEDICAL CENTER   (United States)

^e UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

^f New York Presbyterian Hospital   (United States)

^g UNIVERSITY OF KENTUCKY   (United States)

^h UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

ⁱ HARLEM HOSPITAL CENTER   (United States)

Author keywords

Cytokines; Inflammation; Periodontitis; Pregnancy; Preterm birth

Indexed keywords

AUTACOID; C REACTIVE PROTEIN; ENDOTOXIN; FIBRINOGEN; GELATINASE B; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; PROSTAGLANDIN E2; TUMOR NECROSIS FACTOR ALPHA;

ADOLESCENT; ADULT; ARTICLE; BIRTH WEIGHT; BLOOD; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; FOLLOW UP; GESTATIONAL AGE; HUMAN; NEWBORN; PERIODONTITIS; PREGNANCY; PREGNANCY COMPLICATION; PREGNANCY OUTCOME; PREMATURITY; PREVENTIVE DENTISTRY; RANDOMIZED CONTROLLED TRIAL; RISK FACTOR;

ADOLESCENT; ADULT; BIRTH WEIGHT; C-REACTIVE PROTEIN; DENTAL SCALING; DINOPROSTONE; ENDOTOXINS; FEMALE; FIBRINOGEN; FOLLOW-UP STUDIES; GESTATIONAL AGE; HUMANS; INFANT, NEWBORN; INFLAMMATION MEDIATORS; INTERLEUKIN-1BETA; INTERLEUKIN-6; INTERLEUKIN-8; MATRIX METALLOPROTEINASE 9; PERIODONTITIS; PREGNANCY; PREGNANCY COMPLICATIONS; PREGNANCY OUTCOME; PREMATURE BIRTH; RISK FACTORS; ROOT PLANING; TUMOR NECROSIS FACTOR-ALPHA; YOUNG ADULT;

EID: 72349089160     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2009.090236     Document Type: Article

References (34)

1. Hamilton BE, Martin JA, Ventura SJ. Births: Preliminary data for 2005. Natl Vital Stat Rep 2006;55:1-18.
2. Board on Health Sciences Policy. Institute of Medicine Committee on Understanding Premature Birth and Assuring Healthy Outcomes. Societal Costs of Preterm Birth. In: Behrman RE, Butler AS, eds. Preterm Birth: Causes, Consequences, and Prevention. Washington, DC: National Academies Press; 2007:324-349.
3. Romero R, Gomez R, Chaiworapongsa T, Conoscenti G, Kim JC, Kim YM. The role of infection in preterm labour and delivery. Paediatr Perinat Epidemiol 2001;15(Suppl. 2):41-56.
4. Collins JG, Smith MA, Arnold RR, Offenbacher S. Effects of Escherichia coli and Porphyromonas gingi-valis lipopolysaccharide on pregnancy outcome in the golden hamster. Infect Immun 1994;62:4652-4655.
5. Collins JG, Windley HW 3rd, Arnold RR, Offenbacher S. Effects of a Porphyromonas gingivalis infection on inflammatory mediator response and pregnancy outcome in hamsters. Infect Immun 1994;62:4356-4361.
6. Offenbacher S, Boggess KA, Murtha AP, et al. Progressive periodontal disease and risk of very preterm delivery. Obstet Gynecol 2006;107:29-36.
7. Xiong X, Buekens P, Fraser W, Beck J, Offenbacher S. Periodontal disease and adverse pregnancy outcomes: A systematic review. BJOG 2006;113:135-143.
8. Wimmer G, Pihlstrom BL. A critical assessment of adverse pregnancy outcome and periodontal disease. J Clin Periodontol 2008;35(Suppl. 8):380-397.
9. Klebanoff M, Searle K. The role of inflammation in preterm birth-focus on periodontitis. BJOG 2006;113(Suppl. 3):43-45.
10. Koj A. Initiation of acute phase response and synthesis of cytokines. Biochim Biophys Acta 1996;1317:84-94.
11. Kushner I. Regulation of the acute phase response by cytokines. Perspect Biol Med 1993;36:611-622.
12. Vogel I, Thorsen P, Curry A, Sandager P, Uldbjerg N. Biomarkers for the prediction of preterm delivery. Acta Obstet Gynecol Scand 2005;84:516-525.
13. Vogel I, Goepfert AR, Thorsen P, et al. Early second-trimester inflammatory markers and short cervical length and the risk of recurrent preterm birth. J Reprod Immunol 2007;75:133-140.
14. Michalowicz BS, Hodges JS, DiAngelis AJ, et al. Treatment of periodontal disease and the risk of preterm birth. N Engl J Med 2006;355:1885-1894.
15. Ebersole JL, Cappelli D, Mott G, Kesavalu L, Holt SC, Singer RE. Systemic manifestations of periodontitis in the non-human primate. J Periodontal Res 1999;34:358-362.
16. Ebersole JL, Machen RL, Steffen MJ, Willmann DE. Systemic acute-phase reactants, C-reactive protein and haptoglobin, in adult periodontitis. Clin Exp Immunol 1997;107:347-352.
17. Pussinen PJ, Paju S, Mantyla P, Sorsa T. Serum micro-bial- and host-derived markers of periodontal diseases: A review. Curr Med Chem 2007;14:2402-2412.
18. Tonetti MS, D'Aiuto F, Nibali L, et al. Treatment of periodontitis and endothelial function. N Engl J Med 2007;356:911-920.
19. Ide M, McPartlin D, Coward PY, Crook M, Lumb P, Wilson RF. Effect of treatment of chronic periodontitis on levels of serum markers of acute-phase inflammatory and vascular responses. J Clin Periodontol 2003;30:334-340.
20. D'Aiuto F, Parkar M, Tonetti MS. Acute effects of periodontal therapy on bio-markers of vascular health. J Clin Periodontol 2007;34:124-129.
21. Elter JR, Hinderliter AL, Offenbacher S, et al. The effects of periodontal therapy on vascular endothelial function: A pilot trial. Am Heart J 2006;151:47.
22. Paraskevas S, Huizinga JD, Loos BG. A systematic review and meta-analyses on C-reactive protein in relation to periodontitis. J Clin Periodontol 2008;35:277-290.
23. D'Aiuto F, Nibali L, Parkar M, Suvan J, Tonetti MS. Short-term effects of intensive periodontal therapy on serum inflammatory markers and cholesterol. J Dent Res 2005;84:269-273.
24. Belo L, Santos-Silva A, Rocha S, et al. Fluctuations in C-reactive protein concentration and neutrophil activation during normal human pregnancy. Eur J Obstet Gynecol Reprod Biol 2005;123:46-51.
25. Larsson A, Palm M, Hansson LO, Basu S, Axelsson O. Reference values for alpha1-acid glycoprotein, al-pha1-antitrypsin, albumin, haptoglobin, C-reactive protein, IgA, IgG and IgM during pregnancy. Acta Obstet Gynecol Scand 2008;87:1084-1088.
26. Goldenberg RL, Goepfert AR, Ramsey PS. Biochemical markers for the prediction of preterm birth. Am J Obstet Gynecol 2005;192(Suppl. 5):S36-S46.
27. Tu FF, Goldenberg RL, Tamura T, Drews M, Zucker SJ, Voss HF. Prenatal plasma matrix metalloprotei-nase-9 levels to predict spontaneous preterm birth. Obstet Gynecol 1998;92:446-449.
28. Moawad AH, Goldenberg RL, Mercer B, et al. The Preterm Prediction Study: The value of serum alkaline phosphatase, alpha-fetoprotein, plasma corticotropin-releasing hormone, and other serum markers for the prediction of spontaneous preterm birth. Am J Obstet Gynecol 2002;186:990-996.
29. Lange M, Chen FK, Wessel J, Buscher U, Dudenhausen JW. Elevation of interleukin-6 levels in cervical secretions as a predictor of preterm delivery. Acta Obstet Gynecol Scand 2003;82:326-329.
30. Foulon W, Van Liedekerke D, Demanet C, Decatte L, Dewaele M, Naessens A. Markers of infection and their relationship to preterm delivery. Am J Perinatol 1995;12:208-211.
31. Wenstrom KD, Andrews WW, Hauth JC, Goldenberg RL, DuBard MB, Cliver SP. Elevated second-trimester amniotic fluid interleukin-6 levels predict preterm delivery. Am J Obstet Gynecol 1998;178:546-550.
32. Skrablin S, Lovric H, Banovic V, Kralik S, Dijakovic A, Kalafatic D. Maternal plasma interleukin-6, interleukin-1beta and C-reactive protein as indicators of tocolysis failure and neonatal outcome after preterm delivery. J Matern Fetal Neonatal Med 2007;20:335-341.
33. Kurkinen-Raẗy M, Ruokonen A, Vuopala S, et al. Combination of cervical interleukin-6 and -8, phosphor-ylated insulin-like growth factor-binding protein-1 and transvaginal cervical ultrasonography in assessment of the risk of preterm birth. BJOG 2001;108:875-881.
34. Novak MJ, Novak KF, Hodges JS, et al. Periodontal bacterial profiles in pregnant women: Response to treatment and associations with birth outcomes in the obstetrics and periodontal therapy (OPT) study. J Periodontol 2008;79:1870-1879.