Short-term effects of intensive periodontal therapy on serum inflammatory markers and cholesterol

Journal of Dental Research

Volumn 84, Issue 3, 2005, Pages 269-273

  D'Aiuto, F ^a   Nibali, L ^a   Parkar, M ^a   Suvan, J ^a   Tonetti, M S ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Atherosclerosis; C reactive protein; Cholesterol; Inflammation; Periodontitis

Indexed keywords

ANTIINFECTIVE AGENT; C REACTIVE PROTEIN; CHOLESTEROL; INTERLEUKIN 6; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MINOCYCLINE;

ADULT; AGE; ARTICLE; BLOOD; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; FOLLOW UP; HUMAN; MALE; MIDDLE AGED; PERIODONTAL DISEASE; PERIODONTICS; PERIODONTITIS; RANDOMIZED CONTROLLED TRIAL; SEX DIFFERENCE; SMOKING; TOOTH PLAQUE;

ADULT; AGE FACTORS; ANTI-BACTERIAL AGENTS; C-REACTIVE PROTEIN; CHOLESTEROL; CHOLESTEROL, LDL; DENTAL PLAQUE INDEX; FEMALE; FOLLOW-UP STUDIES; HUMANS; INTERLEUKIN-6; MALE; MIDDLE AGED; MINOCYCLINE; PERIODONTAL ATTACHMENT LOSS; PERIODONTAL POCKET; PERIODONTITIS; SEX FACTORS; SMOKING; SUBGINGIVAL CURETTAGE;

EID: 16844376535     PISSN: 00220345     EISSN: None     Source Type: Journal    
DOI: 10.1177/154405910508400312     Document Type: Article

References (28)

1. Buhlin K, Gustafsson A, Hakansson J, Klinge B (2002). Oral health and cardiovascular disease in Sweden. J Clin Periodontol 29:254-259.
2. D'Aiuto F, Parkar M, Andreou G, Suvan J, Brett PM, Ready D, et al. (2004). Periodontitis and systemic inflammation: control of the local infection is associated with a reduction in serum inflammatory markers. J Dent Res 83:156-160.
3. Ebersole JL, Machen RL, Steffen MJ, Willmann DE (1997). Systemic acute-phase reactants, C-reactive protein and haptoglobin, in adult periodontitis. Clin Exp Immunol 107:347-352.
4. Fernandez-Real JM, Ricart W (2003). Insulin resistance and chronic cardiovascular inflammatory syndrome. Endocr Rev 24:278-301.
5. Gabay C, Kushner I (1999). Acute-phase proteins and other systemic responses to inflammation. N Engl J Med 340:448-454.
6. Graves DT (1999). The potential role of chemokines and inflammatory cytokines in periodontal disease progression. Clin Infect Dis 28:482-490.
7. Hanes PJ, Purvis JP (2003). Local anti-infective therapy: pharmacological agents. A systematic review. Ann Periodontol 8:79-98.
8. Haraszthy VI, Zambon JJ, Trevisan M, Zeid M, Genco RJ (2000). Identification of periodontal pathogens in atheromatous plaques. J Periodontol 71:1554-1560.
9. Herzberg MC, Weyer MW (1998). Dental plaque, platelets, and cardiovascular diseases. Ann Periodontol 3:151-160.
10. Iacopino AM, Cutler CW (2000). Pathophysiological relationships between periodontitis and systemic disease: recent concepts involving serum lipids. J Periodontol 71:1375-1384.
11. Irwin CR, Myrillas TT (1998). The role of IL-6 in the pathogenesis of periodontal disease. Oral Dis 4:43-47.
12. Iwamoto Y, Nishimura F, Soga Y, Takeuchi K, Kurihara M, Takashiba S, et al. (2003). Antimicrobial periodontal treatment decreases serum C-reactive protein, tumor necrosis factor-alpha, but not adiponectin levels in patients with chronic periodontitis. J Periodontol 74:1231-1236.
13. Katz J, Flugelman MY, Goldberg A, Heft M (2002). Association between periodontal pockets and elevated cholesterol and low density lipoprotein cholesterol levels. J Periodontol 73:494-500.
14. Kluft C, de Maat MP (2001). Determination of the habitual low blood level of C-reactive protein in individuals. Ital Heart J 2:172-180.
15. Kweider M, Lowe GD, Murray GD, Kinane DF, McGowan DA (1993). Dental disease, fibrinogen and white cell count; links with myocardial infarction? Scott Med J 38(3):73-74.
16. Libby P, Ridker PM, Maseri A (2002). Inflammation and atherosclerosis. Circulation 105:1135-1143.
17. Loos BG, Craandijk J, Hoek FJ, Wertheim-van Dillen PM, van der Velden V (2000). Elevation of systemic markers related to cardiovascular diseases in the peripheral blood of periodontitis patients. J Periodontol 71:1528-1534.
18. Noack B, Genco RJ, Trevisan M, Grossi S, Zambon JJ, De Nardin E (2001). Periodontal infections contribute to elevated systemic C-reactive protein level. J Periodontol 72:1221-1227.
19. Offenbacher S, Farr DH, Goodson JM (1981). Measurement of prostaglandin E in crevicular fluid. J Clin Periodontol 8:359-367.
20. Papapanou PN (1996). Periodontal diseases: epidemiology. Ann Periodontol 1:1-36.
21. Paquette D, Santucci E (2000). A pharmacokinetic study of a locally delivered minocycline therapeutic system (MPTS) (abstract). J Clin Periodontol 27(Suppl 1):12.
22. Paquette D, Oringer R, Lessem J, Offenbacher S, Genco R, Persson GR, et al. (2003). Locally delivered minocycline microspheres for the treatment of periodontitis in smokers. J Clin Periodontol 30:787-794.
23. Pearson TA, Mensah GA, Alexander RW, Anderson JL, Cannon RO III, Criqui M, et al. (2003). Markers of inflammation and cardiovascular disease: application to clinical and public health practice: a statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation 107:499-511.
24. Pocock SJ (1979). Allocation of patients to treatment in clinical trials. Biometrics 35:183-197.
25. Pradhan AD, Manson JE, Rossouw JE, Siscovick DS, Mouton CP, Rifai N, et al. (2002). Inflammatory biomarkers, hormone replacement therapy, and incident coronary heart disease: prospective analysis from the Women's Health Initiative observational study. J Am Med Assoc 288:980-987.
26. Pussinen PJ, Jauhiainen M, Vilkuna-Rautiainen T, Sundvall J, Vesanen M, Mattila K, et al. (2004). Periodontitis decreases the antiatherogenic potency of high density lipoprotein. J Lipid Res 45:139-147.
27. Uchiumi D, Kobayashi M, Tachikawa T, Hasegawa K (2004). Subcutaneous and continuous administration of lipopolysaccharide increases serum levels of triglyceride and monocyte chemoattractant protein-1 in rats. J Periodontal Res 39:120-128.
28. Williams RC (1990). Periodontal disease. N Engl J Med 322:373-382.